A5047330054- Nutritional Studies and Diet
- Mass Spectrometry Techniques and Applications
- Forensic Toxicology and Drug Analysis
- Vitamin D Research Studies
- Analytical Chemistry and Chromatography
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Poisoning and overdose treatments
- Nutrition and Health in Aging
- Intraocular Surgery and Lenses
- Obesity and Health Practices
- Health and Medical Studies
- Corneal surgery and disorders
- Pulmonary Hypertension Research and Treatments
- Anesthesia and Neurotoxicity Research
- Frailty in Older Adults
- Microfluidic and Capillary Electrophoresis Applications
- Respiratory Support and Mechanisms
- Restraint-Related Deaths
- Analytical Methods in Pharmaceuticals
- Adipose Tissue and Metabolism
- Physical Activity and Health
- Glaucoma and retinal disorders
- Metabolomics and Mass Spectrometry Studies
- Body Composition Measurement Techniques
University of Freiburg
2000-2024
Vifor Pharma (Germany)
2024
Helmholtz Zentrum München
2015-2018
German Centre for Cardiovascular Research
2016
University Medical Center Freiburg
2015
Universitätsklinikum Gießen und Marburg
2015
Philipps University of Marburg
2013
Illinois College of Optometry
2009
University Hospital Magdeburg
2007
Universitätsaugenklinik Magdeburg
2007
Excess body weight is a major risk factor for cardiometabolic diseases. The complex molecular mechanisms of change-induced metabolic perturbations are not fully understood. Specifically, in-depth characterization long-term change in the general population lacking. Here, we pursued multi-omic approach to comprehensively study consequences during seven-year follow-up large prospective study. We used data from population-based Cooperative Health Research Region Augsburg (KORA) S4/F4 cohort. At...
Sildenafil, approved for pulmonary arterial hypertension (PAH), has a recommended adult dose of 20 mg TID, with previously 5-mg TID by the US Food and Drug Administration. Safety concerns arose because common off-label use higher doses, particularly after pediatric data linked doses to increased mortality. To assess this, Administration mandated study evaluating effects various sildenafil on mortality in adults PAH.
Tuning compounds for positive and negative electrospray ionization (ESI) were tested the tuning of in-source collision-induced dissociation (ESI/CID) with three types SCIEX API instruments (API 365, 2000 3000) in single-quadrupole mode. The vacuum interfaces these differ slightly geometry, but principles solvent evaporation by nebulizer curtain gases, orifice skimmer are identical. For comparison CID, breakdown curves haloperidol, paracetamol, metronidazole metamizole acquired increasing...
Hair samples of psychiatric patients were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS-MS) for the neuroleptics clozapine, flupentixol, haloperidol, penfluridol, thioridazine, and zuclopenthixol. In study, these administered to regularly a minimum six months. Sample preparation was performed washing, powdering with ball mill, extraction drugs from hair ultrasonication methanol, cleanup solid-phase subsequent LC-MS-MS analysis using multiple reaction monitoring (MRM)....
Background: Numerous observational studies have observed associations between vitamin D deficiency and cardiometabolic diseases, but these findings might be confounded by obesity. A characterization of the metabolic profile associated with serum 25-hydroxyvitamin [25(OH)D] levels, in general stratified abdominal obesity, may help to untangle relationship D, obesity health. Methods: Serum metabolomics measurements were obtained from a nuclear magnetic resonance spectroscopy (NMR)- mass...
To examine the interaction between waist circumference (WC) and serum 25-hydroxyvitamin D (25(OH)D) level in their associations with lipids.Cross-sectional study. The of 25(OH)D total cholesterol, HDL cholesterol (HDL-C), LDL (LDL-C), LDL-C:HDL-C TAG were examined using multiple linear regression. Effect modification by WC was assessed through cross-product terms categories (abdominal overweight, 80-<88 cm females/94-<102 males; abdominal obesity, ≥88 females/≥102 males).The US National...
To evaluate whether a low sympathetic activity is essential for the onset of Zucker rat obesity, we artificially reared fa/fa and Fa/fa littermates from 4 days age with identical amounts milk containing norepinephrine (NE). The NE concentration was adjusted to keep mass-specific metabolic rate (MR) roughly either 100 or 50% above its thermoneutral level. At both doses, no genotype difference in total MR occurred before day 16, but between 16 21 age, pups 10% less than that their littermates....
As ageing is associated with changes in body composition, BMI may not be the appropriate obesity measure for older adults. To date, little known about associations between measures and health-related quality of life (HRQoL). Thus, we aimed to compare different their association HRQoL self-rated physical constitution (SRPC) adults.Seven (BMI, waist circumference (WC), waist-to-hip ratio, waist-to-height fat mass percentage based on bioelectrical impedance analysis, hypertriglyceridaemic...
Results on the association between vitamin D and blood pressure are conflicting little is known about how their relationship may be affected by obesity. Thus, we explored whether waist circumference modified serum 25-hydroxyvitamin (25(OH)D) in participants of U.S. National Health Nutrition Examination Surveys 2001-2006.We included 10 331 nonpregnant aged 20 years or older. The 25(OH)D with systolic diastolic pressure, total sample stratified category (abdominal overweight: 80 to <88 cm...