A5072992929- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Intensive Care Unit Cognitive Disorders
- Pharmacological Effects and Toxicity Studies
- Anesthesia and Sedative Agents
- Simulation-Based Education in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Cardiac Imaging and Diagnostics
- Disaster Response and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Palliative Care and End-of-Life Issues
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Heart Rate Variability and Autonomic Control
- Anesthesia and Neurotoxicity Research
University Hospital of Basel
2015-2024
University of Basel
2011-2024
Hospital Base
2003-2024
Witten/Herdecke University
2024
Bethesda Hospital
2024
University of Veterinary Medicine Vienna
2023
Holbæk Sygehus
2023
Empirical Technologies (United States)
2023
Saarland University
2023
University Hospital of Geneva
2021
<h3>Background</h3> The administration of radiographic contrast agents remains an important cause acute renal failure. optimal infusion for hydration has not been evaluated. <h3>Objective</h3> To compare the incidence media–associated nephrotoxicity with isotonic or half-isotonic hydration. <h3>Design</h3> Prospective, randomized, controlled, open-label study. <h3>Methods</h3> Patients scheduled elective emergency coronary angioplasty were randomly assigned to receive (0.9% saline) (0.45%...
In patients with ventilator-associated pneumonia (VAP), guidelines recommend antibiotic therapy adjustment according to microbiology results after 72 h. Circulating procalcitonin levels may provide evidence that facilitates the reduction of therapy. a multicentre, randomised, controlled trial, 101 VAP were assigned an discontinuation strategy (control group) or serum concentrations (procalcitonin regimen selected by treating physician. The primary end-point was antibiotic-free days alive...
To evaluate the risks of continuously administered IV anesthetic drugs (IVADs) on outcome adult patients with status epilepticus (SE).All intensive care unit SE from 2005 to 2011 at a tertiary academic medical center were included. Relative calculated for primary measures seizure control, Glasgow Outcome Scale score discharge, and death. Poisson regression models used control possible confounders assess effect modification.Of 171 patients, 37% treated IVADs. Mortality was 18%. Patients had...
<h3>Importance</h3> End-of-life decisions occur daily in intensive care units (ICUs) around the world, and these practices could change over time. <h3>Objective</h3> To determine changes end-of-life European ICUs after 16 years. <h3>Design, Setting, Participants</h3> Ethicus-2 was a prospective observational study of 22 previously included Ethicus-1 (1999-2000). During self-selected continuous 6-month period at each ICU, consecutive patients who died or had any limitation life-sustaining...
This study sought to evaluate the predictive value of C-reactive protein (CRP) on long-term mortality in non-ST-elevation acute coronary syndromes (NSTACS) that were treated with a very early aggressive revascularization strategy.We conducted prospective cohort 1042 consecutive patients NSTACS who undergoing angiography and subsequent stenting culprit lesion as primary strategy within 24 hours. Levels CRP determined admission. The followed for mean 20 months. In-hospital was significantly...
To develop an intelligent sensor−effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and pH-sensitive enzyme acid phosphatase, resulting in switchable substrate processing at pH 4−6.5. Ideal concentrations for reaction determined experimentally. In future, reactor might be used self-regulating targeted diagnostic therapeutic applications...
The influence of teaching leadership on the performance rescuers remains unknown. aim this study was to compare instruction with a general technical in high-fidelity simulated cardiopulmonary resuscitation scenario.Prospective, randomized, controlled superiority trial.Simulator Center University Hospital Basel Switzerland.Two-hundred thirty-seven volunteer medical students teams three.During baseline visit, participated video-taped witnessed cardiac arrest. Participants were thereafter...
Abstract Introduction The Glasgow Coma Scale (GCS) is the most widely used scoring system for comatose patients in intensive care. Limitations of GCS include impossibility to assess verbal score intubated or aphasic patients, and an inconsistent inter-rater reliability. FOUR (Full Outline UnResponsiveness) score, a new coma scale not reliant on response, was recently proposed. aim present study compare reliability among unselected general critical A further neurologists with that care unit...
Summary Purpose Refractory status epilepticus ( RSE ) is a life‐threatening neurologic emergency with high mortality and morbidity. The aim of this study was to identify quantify associations between clinical characteristics adult patients outcome. Methods Comprehensive medical chart review performed all consecutive treated on the intensive care units an academic tertiary center 2005 2011. Demographics, etiologies duration, comorbidities, as well outcomes were assessed. Associations death...
Abstract Background Cardiac arrests are handled by teams rather than individual health-care workers. Recent investigations demonstrate that adherence to CPR guidelines can be less optimal, deviations from treatment algorithms associated with lower survival rates, and deficits in performance shortcomings the process of team-building. The aim this study was explore quantify effects ad-hoc team-building on among two types physicians play an important role as first responders during CPR: general...
Abstract Objectives SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- hospital-acquired among pneumonia is scarce. Methods We identified 220 SARS-CoV-2-positive hospitalized at the University Hospital Basel, Switzerland (between 25 February 31 May 2020). excluded who declined general consent ( n = 12), without clinical evidence of 29), for < 24 h 17). evaluated...
<h3>Objective:</h3> To investigate the frequency of induced electroencephalographic (EEG) burst-suppression pattern during continuous intravenous anesthesia (IVAD) and associated outcomes in adult patients treated for refractory status epilepticus (RSE). <h3>Methods:</h3> Patients with RSE anesthetics at a Swiss academic care center from 2011-2019 were included. Clinical data semiquantitative EEG analyses assessed. Burst-suppression was categorized as incomplete (with ≥20% <50%...
Interleukin (IL)-6 regulates various aspects of the immune response. In context heart diseases, it has been recognized as a prognostic factor for dilated cardiomyopathy, which often results from myocarditis.Using IL-6-deficient mice, we studied role IL-6 in model autoimmune myocarditis resulting immunization with peptide derived cardiac alpha-myosin. Prevalence and severity were markedly reduced absence IL-6. CD4+ T cells immunized mice proliferated poorly on restimulation specific antigen...
Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set enzymes. Here we report the design synthetic based on nanometer-sized polymer vesicles, show their introduction into cells in target-specific fashion, document intact biochemical functionality cellular environment, and study intracellular trafficking. This novel paradigm introducing polymer-based artificial to target for expansion...
Status epilepticus (SE) is an important neurologic emergency requiring treatment on intensive care unit (ICU). Although convulsive SE self-evident, the diagnosis of nonconvulsive (NCSE) depends electroencephalography (EEG) confirmation. Previous work showed that 82% patients with had NCSE in our ICU. We hypothesize continuous video-EEG monitoring (CVEM) may increase diagnostic yield SE, especially NCSE, and leave fewer undiagnosed.We retrospectively assessed EEG reports 537 suspected during...
Abstract Introduction Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. Concerns relate the side effects of succinylcholine slower onset inferior conditions associated with rocuronium. So far, have not been compared an adequately powered randomized trial Accordingly, aim present study was compare incidence hypoxemia after or critically ill patients requiring emergent RSI. Methods This a prospective controlled...