A5035010617- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Digital Mental Health Interventions
- Diabetes Management and Research
- Pulmonary Hypertension Research and Treatments
- Renal and Vascular Pathologies
- Diabetes Management and Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Electrolyte and hormonal disorders
- Clinical practice guidelines implementation
- Multiple Sclerosis Research Studies
- Medication Adherence and Compliance
- Asthma and respiratory diseases
- Connective tissue disorders research
- Acute Kidney Injury Research
- Electronic Health Records Systems
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Disease Management Strategies
- Renal function and acid-base balance
- Autism Spectrum Disorder Research
- Respiratory Support and Mechanisms
- Neurogenetic and Muscular Disorders Research
- Cardiac electrophysiology and arrhythmias
- Prostate Cancer Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
Bayer (Germany)
2018-2024
University Hospital of Bern
2015
Charité - Universitätsmedizin Berlin
2013
University Hospital of Basel
2012
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2002-2007
<h3>Background</h3> The administration of radiographic contrast agents remains an important cause acute renal failure. optimal infusion for hydration has not been evaluated. <h3>Objective</h3> To compare the incidence media–associated nephrotoxicity with isotonic or half-isotonic hydration. <h3>Design</h3> Prospective, randomized, controlled, open-label study. <h3>Methods</h3> Patients scheduled elective emergency coronary angioplasty were randomly assigned to receive (0.9% saline) (0.45%...
The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens sodium bicarbonate with 24 h chloride 0.9% infusion in CIN.We performed a prospective, randomized trial between March 2005 and December 2009, including 258 consecutive patients renal insufficiency undergoing intravascular contrast procedures. Patients were receive intravenous volume supplementation either (A) 1 mL/kg/h at least 12h prior after...
Data transfer between electronic health records (EHRs) at the point of care and data capture (EDC) systems for clinical research is still mainly carried out manually, which error-prone as well cost- time-intensive. Automated digital from EHRs to EDC (EHR2EDC) would enable more accurate efficient but has so far encountered technological barriers primarily related format environment: in Germany, are collected a variety often individualized practice management (PMSs), most them not...
Abstract Objectives: We prospectively studied the long‐term outcome of endovascular treatment instent renal artery stenosis (IRAS). Background: Restenosis is a considerable drawback stent‐supported angioplasty especially in small vessel diameters. The appropriate strategy not yet defined. Patients and Methods: During 10‐year period 56 consecutive patients (65 lesions) with their first IRAS were included prospective follow‐up program (mean 53 ± 25 months, range 6–102). Primary endpoint study...
Background Diabetes mellitus (DM) is one of the most common noncommunicable diseases. DM has a substantial negative impact on patients’ quality life, which measured using variety diabetes-specific measures covering multiple aspects psychological state, behavior, and treatment satisfaction. A fully digital data collection system, including patient identification, would represent advance in how these patient-reported outcome (PRO) are measured. Within European Union, way to identify patients...
Background Pulmonary arterial hypertension restricts the ability of patients to perform routine physical activities. As part pulmonary treatment, inhaled iloprost can be administered via a nebulizer that tracks inhalation behavior. treatment is guided by intermittent clinical measurements, such as 6-minute walk distance, assessed during regular physician visits. Continuous digital monitoring activity may facilitate more complete assessment impact on daily life. Physical tracking with...
Despite effective treatment options, chronic kidney disease (CKD) has become a major cause of mortality worldwide due to the ever-increasing number patients with type 2 diabetes mellitus (T2DM). Guideline-compliant, at least, annual screening T2DM is crucial prevent renal progression. However, data on prevalence CKD in and frequency are limited. SMART-Finder first study exclusively use provided directly by via an adherence app collect information CKD, risk factors, management, quality life...
Pulmonary arterial hypertension (PAH)-a progressive, ultimately fatal disease-patients often experience dyspnea, which can limit their daily physical activities. Iloprost is an inhaled therapy for PAH that has shown efficacy in clinical trials. However, trials have provided only limited data on activity. Digital monitoring of activity therefore attracting growing interest. To fully understand a patient's response to treatment, treatment adherence also required. The Breelib nebulizer...
Background The BETACONNECT autoinjector and myBETAapp app were designed to support patients with multiple sclerosis receiving interferon β-1b are an ideal platform for digital observational studies. A recent pilot study in Germany demonstrated the feasibility of using recruit patients, obtain informed consent, evaluate medication-taking behavior over 6 months. Objective This aims describe 1 year based on data collected from provide information patient-reported outcomes (PROs). optional use...
<sec> <title>BACKGROUND</title> Chronic kidney disease (CKD) is a common comorbidity of type 2 diabetes mellitus (T2DM). Data on the determination CKD-related biomarkers in real-life setting patients with T2DM Germany are limited. </sec> <title>OBJECTIVE</title> We aimed to determine prevalence CKD and risk factors, availability urine albumin-to-creatinine ratio (UACR) estimated glomerular filtration rate (eGFR) values, treatment satisfaction, quality life Germany. <title>METHODS</title>...
Chronic kidney disease (CKD) is a common comorbidity of type 2 diabetes mellitus (T2DM). Data on the determination CKD-related biomarkers among patients with T2DM in real-life setting within Germany are limited. We aimed to determine prevalence CKD and risk factors, availability urine albumin-to-creatinine ratio (UACR) estimated glomerular filtration rate (eGFR) values, treatment satisfaction, quality life Germany. SMART-Finder retrospective prospective, observational, digital,...
<sec> <title>BACKGROUND</title> Data transfer between electronic health records (EHRs) at the point of care and data capture (EDC) systems for clinical research is still mainly carried out manually, which error-prone as well cost- time-intensive. Automated digital from EHRs to EDC (EHR2EDC) would enable more accurate efficient but has so far encountered technological barriers primarily related format environment: in Germany, are collected a variety often individualized practice management...
<sec> <title>UNSTRUCTURED</title> N/A </sec>
The use of digital technology to assess patients remotely can reduce clinical study costs. In the European Union, 2D matrix code on prescription drug packaging serves as a unique identifier given package medication, and thus, also patient receiving that medication. Scanning may therefore allow remote authentication in studies.The aim DePRO was feasibility fully data-capture workflow, participants via codes, with type 2 diabetes mellitus (T2DM) who metformin. primary objective describe...
Purpose: Copeptin, an extremely promising new biomarker, may aid to shorten the process of MI-rule out in patients with cardiac chief complaints ED. In this study, diagnostic performance copeptin as well distribution diagnoses copeptin-positive and –negative ED was determined. Methods: Patients acute dyspnea (n=305) or chestpain (n=232) were enrolled Blood samples obtained within two hours after admission. Copeptin determined using ultrasensitive Assay (Thermofisher Scientific). The cut-off...