A5059917637- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Airway Management and Intubation Techniques
- Hedgehog Signaling Pathway Studies
- Occupational and environmental lung diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal and GI Pathology
- Ultrasound in Clinical Applications
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Myasthenia Gravis and Thymoma
- Trauma Management and Diagnosis
- Soft tissue tumor case studies
- Congenital Diaphragmatic Hernia Studies
- Thyroid and Parathyroid Surgery
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Pneumothorax, Barotrauma, Emphysema
- Anesthesia and Pain Management
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
- Sympathectomy and Hyperhidrosis Treatments
University of Campania "Luigi Vanvitelli"
2016-2025
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2019-2024
University of Naples Federico II
2008-2017
NorthEast Regional Epilepsy Group
2016
Research Network (United States)
2016
Hospital Universitario de Móstoles
2013
Thoracic Surgery Foundation
2010
Resistance to tyrosine kinase inhibitors (TKI) of EGF receptor (EGFR) is often related activation other signaling pathways and evolution through a mesenchymal phenotype.Because the Hedgehog (Hh) pathway has emerged as an important mediator epithelial-to-mesenchymal transition (EMT), we studied Hh in models EGFR-TKIs intrinsic or acquired resistance from both EGFR-mutated wild-type (WT) non-small cell lung cancer (NSCLC) lines.Activation was found EGFR-WT NSCLC line resistant EGFR-TKIs. In...
Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is strong rationale for combining them with targeted therapy. Inhibition MAPK pathway may have pleiotropic effects on the microenvironment. This work investigates efficacy MEK PD-L1 inhibition pre-clinical ex-vivo models.We studied inhibitors (MEK-I) MCH-I protein expression cytokine production vitro cell lines PBMCs from healthy donors patients, MEK-I anti-PD-L1 antibody human spheroid cultures...
<h2>ABSTRACT</h2><h3>Purpose</h3> Our previous works demonstrated the ability of metformin to revert resistance gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in non-small-cell lung cancer (NSCLC) EGFR/LKB1 wild-type (WT) cell lines. However, optimal dose be used non-diabetic patients still remains defined. The phase I–II trial METformin Advanced Lung (METAL) was designed identify maximum tolerated and evaluate safety activity combined with...
The goal of our study was to molecularly dissect mesothelioma tumour pathways by mean microarray technologies in order identify new biomarkers that could be used as early diagnostic markers and possibly specific molecular therapeutic targets.
<b>Background</b> The aim of the study was to evaluate influence nutritional status on outcome elderly patients resected for lung cancer. <b>Materials and Methods</b> A total 117 consecutive aged ≥ 70 years undergoing cancer resection were enrolled. In addition routine preoperative evaluations, other variables such as body mass index, weight loss, serum albumin, lymphocytes, transferrin counted. According index value, divided into Group (≤ 18.5, underweight) B (> 18.5) risk factors morbidity...
Objective: We evaluated the validity of an electrothermal bipolar tissue sealing system (LigaSure, Valleylab Inc., USA) in lung surgery. Methods: Our study was divided into two phases. Experimental: performed sutures pulmonary vessels and bronchi wedge resections by LigaSure 28 lungs adult pigs; subsequently, we quantitated capacity detecting burst pressure for each anatomical structure. Clinical: used 36 patients undergoing 23 thoracotomic procedures 16 (19 resections, 2 segmentectomies,...
Objective: We aimed to evaluate the feasibility and short-term efficacy of endobronchial treatment with one-way valves for giant emphysematous bulla in surgically unfit patients. Methods: Nine consecutive patients were enrolled last 3 years. Endobronchial placed segmental bronchi functionally isolate airway that supplied bulla, favouring deflation its atelectasis. Mean value ± standard deviation forced expiratory volume 1 s (FEV1), preoperative vital capacity (FVC) residual (RV) were: 1.0...
To evaluate the efficacy of Endo-Bronchial Valves in management persistent air-leaks (PALs) and procedural cost.It was a retrospective multicenter study including consecutive patients with PALs for alveolar pleural fistula (APF) undergoing valve treatment. We assessed cost procedure.Seventy-four air leaks due to various etiologies were included analysis. In all cases severe refractory standard treatments. Sixty-seven (91%) underwent treatment obtaining complete resolution 59 (88%) patients;...
Our goal was to determine the role of vascular endothelial growth factor (VEGF) in diagnosing pleural effusion (PE) order select patients deserving more aggressive procedures. Seventy-nine consecutive with undiagnosed unilateral PE were enrolled. Pleural VEGF levels, measured using enzyme-linked immunosorbent assay (ELISA), correlated etiology PEs and other markers (protein, lactic dehydrogenase, amylase, glucose). The median level exudates (n=65) significantly higher than that transudates...
Continuous wound infusion of local anaesthetics has been successfully applied for postoperative pain control in several procedures but, surprisingly, it is underused thoracic surgery. We aimed to investigate the effects analgesia associated with systemic patient-controlled patients undergoing lung cancer resection muscle-sparing thoracotomy. Sixty consecutive via standard thoracotomy were randomized into two groups (wound and placebo groups). Bupivacaine group free-saline solution injected...
The purpose of our study was to determine whether the assessment diffusing capacity lung for carbon monoxide (DL (CO)), together with forced expiratory volume in 1 second (FEV (1)), could improve selection surgical patients.The data 76 patients undergoing major resection (pnemonectomy, bilobectomy or lobectomy) non-small cell cancer were retrospectively studied. All reviewed age, sex, preexisting medical conditions, operative, and pathological findings postoperative outcome.Univariate...
Our goal is to determine whether infiltration with a short-acting local anaesthetic such as lidocaine before the surgical incision has pre-emptive effect on postoperative pain intensity and incidence of paraesthesia in patients undergoing standard thoracoscopic sympathectomy for palmar hyperhidrosis.This prospective study includes consecutive series 18 bilateral hyperhidrosis during January 2005-December 2007. Each patient enrolled was randomised receive pre-incisional epinephrine wounds one...
The data of a consecutive series habitual marijuana smokers were retrospectively evaluated and compared with that non-marijuana to assess differences between the 2 groups.13 referred for treatment spontaneous pneumothorax. demographic, clinical, radiological, pathological findings these patients reviewed 140 treated same pathology at time.Bullae seen in 8/13 (62%) 110/140 (78%) smokers, respectively. However, when less than 35-years old considered, incidence bulla was higher (7/10 vs. 3/10,...
To investigate the role of volume quantitative assessment using multidetector-row computed tomography to select patients scheduled for endobronchial one-way valves treatment.Twenty-five consecutive (15 with heterogeneous emphysema and 10 giant emphysematous bulla) undergoing treatment were enrolled. All studied pre- postoperatively standard pulmonary functional tests target lobe entire lung. Emphysematous parenchyma was obtained applying density thresholds -1.024/-950 Hounsfield units. Among...
Context.— Fine-needle aspiration cytology (FNAC) of pulmonary nodules is usually guided by computed tomography (CT), whereas ultrasonography (US) generally considered not applicable for such purposes. Objective.— To evaluate the clinical applicability and diagnostic utility US-guided transthoracic FNAC peripheral nodules. Design.— Ultrasonography-guided was obtained from 40 selected patients with peripheral, subpleural, paravertebral Air-dried Diff-Quik–stained smears were used rapid on-site...
Enhanced recovery after surgery protocols have shown improved clinical outcomes lung resection surgery, but their application empyema is still limited. We retrospectively evaluated the of an adapted enhanced (ERAS) protocol for immunocompromised patients who underwent video-assisted thoracoscopic (VATS) chronic between December 2013 and 2021. The were divided into ERAS group a conventional treatment group. Peri-operative data collected compared two groups. primary outcome was post-operative...
ABSTRACT Introduction The mediastinum is a complex anatomical region that contains vital structures such as the great vessels, heart, esophagus, and trachea. Mediastinal masses include wide range of lesions, both malignant benign. Our study aimed to evaluate whether combination intraoperative ultrasound (IUS) VATS can allow obtaining an adequate, correct, safer diagnosis in patients with mediastinal mass, especially severely ill affected by heart failure, renal advanced oncological stage,...
Abstract OBJECTIVES Malignant central airway obstruction (MCAO) is a condition characterized by severe dyspnoea and high mortality. Tracheobronchial stents have emerged as an effective treatment to restore patency. Our study aimed evaluate the efficacy of 3D reconstruction upper airways plan tracheo-bronchial stent insertion for MCAO. METHODS This was retrospective, single-center observational study. We analysed data patients under-going MCAO from 01/2012 01/2024. Patients undergoing with...
Background: Lung cancer remains the leading cause of cancer-related mortality, often diagnosed at advanced stages, where minimally invasive tissue sampling is essential for diagnosis and molecular profiling. Rapid On-Site Evaluation (ROSE) enhances diagnostic yield small biopsies, but frequently limited by a shortage pathologists logistical constraints. Telepathology offers potential solution enabling remote real-time assessment. This study evaluates feasibility, accuracy, efficiency...
ABSTRACT The thoracoscopic management of hilar calcified lymph nodes is a technical challenge as the dense adhesions with bronchus and vessels prevented safe dissection. Herein, we reported unexpected bleeding after firing mediastinal trunk pulmonary artery during completion right upper lobectomy for lung cancer. was successfully fixed by an emergent thoracotomy. We used standard white vascular cartridge that probably unable to staple thick tissue, such vessel node. Thus, best strategy...
Airway stenting is the chosen treatment for patients affected by subglottic tracheal stenosis and unfit surgery. Among different types of prostheses, Dumon stent a valid option especially in without tracheotomy. Insertion usually achieved pushing off from loader using prosthesis pusher. If expelled below stenosis, rigid forceps grasping proximal end retract it above stenosis. However, difficult cases such as with luminal diameter smaller than profile stent, manoeuvre may be non-expert hands....