Amam Mbakwem

ORCID: 0000-0003-3395-9042
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About
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Research Areas
  • Cardiovascular Issues in Pregnancy
  • Cardiac Structural Anomalies and Repair
  • Blood Pressure and Hypertension Studies
  • Pulmonary Hypertension Research and Treatments
  • Heart Failure Treatment and Management
  • Cardiovascular Function and Risk Factors
  • Cardiac Arrhythmias and Treatments
  • Congenital Heart Disease Studies
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Cardiac pacing and defibrillation studies
  • Cardiomyopathy and Myosin Studies
  • Cardiac Health and Mental Health
  • Acute Myocardial Infarction Research
  • Health Promotion and Cardiovascular Prevention
  • Global Public Health Policies and Epidemiology
  • Maternal and fetal healthcare
  • Heart Rate Variability and Autonomic Control
  • Kawasaki Disease and Coronary Complications
  • Infective Endocarditis Diagnosis and Management
  • HIV-related health complications and treatments
  • Pharmaceutical Practices and Patient Outcomes
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Phonocardiography and Auscultation Techniques
  • Streptococcal Infections and Treatments

Lagos University Teaching Hospital
2014-2025

University of Lagos
2016-2025

Invictus Medical (United States)
2024

Brookdale University Hospital and Medical Center
2023

Colchester Hospital
2023

East Suffolk and North Essex NHS Foundation Trust
2023

Blackburn College
2023

University of Port Harcourt Teaching Hospital
2022

University of Ibadan
2021

Bayero University Kano
2020-2021

We sought to describe the clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy (PPCM) globally.In 2011, >100 national affiliated member cardiac societies of European Society Cardiology (ESC) were contacted contribute a global registry on PPCM, under auspices ESC EURObservational Research Programme. These tasked identifying centres who could participate this registry. In low-income countries, e.g. Mozambique or Burkina Faso, where there are no due...

10.1093/eurheartj/ehaa455 article EN European Heart Journal 2020-05-13

The risk of heart failure progression or mortality in patients with peri-partum cardiomyopathy (PPCM) during subsequent pregnancies (SSPs) is a significant concern for patients, their families, and healthcare providers. However, there limited contemporary, prospective data on SSP outcomes PPCM from diverse ethnic sociodemographic groups. This study aimed to assess maternal neonatal undergoing SSPs. sub-study SSPs the global European Society Cardiology Registry that recruited 2012 2023....

10.1093/eurheartj/ehaf006 article EN other-oa European Heart Journal 2025-01-02

Abstract This position paper focusses on the pathophysiology, diagnosis and management of women diagnosed with a cardiomyopathy, or at risk heart failure (HF), who are planning to conceive present ( de novo previously unknown) HF during after pregnancy. includes heterogeneous group muscle diseases such as hypertrophic, dilated, arrhythmogenic right ventricular non‐classified cardiomyopathies, left non‐compaction, peripartum Takotsubo syndrome, adult congenital disease HF, patients HF. Also,...

10.1002/ejhf.2133 article EN cc-by-nc-nd European Journal of Heart Failure 2021-02-21

INTERASPIRE is an international study of coronary heart disease (CHD) patients, designed to measure if guideline standards for secondary prevention and cardiac rehabilitation are being achieved in a timely manner. Between 2020 2023, adults hospitalized the preceding 6-24 months with incident or recurrent CHD were sampled 14 countries from all 6 World Health Organization regions invited standardized interview examination. Direct age sex standardization was used country-level prevalence...

10.1093/eurheartj/ehae558 article EN other-oa European Heart Journal 2024-08-30

Abstract Aims The aim of this study was to describe the incidence, clinical characteristics and risk factors peripartum cardiomyopathy (PPCM) in Nigeria. Methods Results conducted 22 hospitals Nigeria, PPCM patients were consecutively recruited between June 2017 March 2018. To determine associated with PPCM, compared apparently healthy women who recently delivered, as controls. Four hundred six 99 incidence disease burden (based on rate consecutive recruitment subjects) varied widely...

10.1002/ehf2.12562 article EN cc-by-nc-nd ESC Heart Failure 2020-01-28

Pulmonary hypertension (PH) is a devastating, progressive disease with increasingly debilitating symptoms and usually shortened overall life expectancy due to narrowing of the pulmonary vasculature consecutive right heart failure. Little known about PH in Africa, but limited reports suggest that more prevalent Africa compared developed countries high prevalence risk factors region.

10.1136/bmjopen-2014-005950 article EN cc-by-nc BMJ Open 2014-10-01

To provide comprehensive information on the access and use of cardiac implantable electronic devices (CIED) catheter ablation procedures in Africa.The Pan-African Society Cardiology (PASCAR) collected data invasive management arrhythmias from 2011 to 2016 31 African countries. A specific template was completed by physicians, additional obtained industry. Information health care systems, demographics, economics, procedure rates, training programs collected. Considerable heterogeneity...

10.1093/europace/eux353 article EN cc-by-nc EP Europace 2017-12-21

Abstract Aims Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive co‐exist, and to what extent they impact outcomes, is less clear. We describe differences phenotype outcomes PPCM without during pregnancy. Methods results The European Society of Cardiology EURObservational Research Programme Registry enrolled from 2012–2018. Three groups were examined: (i) hypertension (PPCM‐noHTN); (ii) but pre‐eclampsia (PPCM‐HTN); (iii) (PPCM‐PE). Maternal...

10.1002/ejhf.2264 article EN cc-by-nc European Journal of Heart Failure 2021-06-11

Nigeria is the most populous country in Africa with highest gross domestic product (GDP) as of 2022. However, burdened by significant health challenges including an extremely high maternal mortality ratio, inadequate human resources, poor healthcare infrastructure, and population-level poverty rates 40%. also has reported prevalence peripartum cardiomyopathy worldwide which contributes to mortality. Unfortunately, diagnosis often delayed following are (approximately 50%). Thus, there a huge...

10.3389/fcvm.2025.1516088 article EN cc-by Frontiers in Cardiovascular Medicine 2025-03-11

Depression is a major issue in heart failure (HF). present about one five HF patients, with 48 % of these individuals having significant depression. There wide variation reported prevalences because differences the cohorts studied and methodologies. are shared pathophysiological mechanisms between The adverse effects depression on outcomes include reduced quality life, healthcare use, rehospitalisation increased mortality. Results from metaanalysis suggest twofold increase mortality patients...

10.15420/cfr.2016:21:1 article EN Cardiac failure review 2016-01-01

Abstract Aims In peripartum cardiomyopathy (PPCM), electrocardiography (ECG) and its relationship to echocardiography have not yet been investigated in large multi‐centre multi‐ethnic studies. We aimed identify ECG abnormalities associated with PPCM, including regional ethnic differences, their correlation echocardiographic features. Methods results studied 411 patients from the EURObservational PPCM registry. Baseline demographic, clinical, data were collected. ECGs analysed for rate,...

10.1002/ehf2.13172 article EN cc-by-nc ESC Heart Failure 2021-01-16

Nigeria has the highest reported incidence of peripartum cardiomyopathy worldwide. This open-label, pragmatic clinical trial randomized pregnant and postpartum women to usual care or artificial intelligence (AI)-guided screening assess its impact on diagnosis left ventricular systolic dysfunction (LVSD) in perinatal period. The study intervention included digital stethoscope recordings with point of-care AI predictions a 12-lead electrocardiogram asynchronous for LVSD. primary end was...

10.1038/s41591-024-03243-9 article EN cc-by-nc-nd Nature Medicine 2024-09-02
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