A5034517238- Chronic Myeloid Leukemia Treatments
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- COVID-19 and healthcare impacts
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatological and COVID-19 studies
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Complement system in diseases
- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobinopathies and Related Disorders
- Diabetes and associated disorders
- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Antimicrobial Peptides and Activities
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Cerebrovascular and genetic disorders
Kayseri Eğitim ve Araştırma Hastanesi
2025
Hacettepe University
2017-2024
Konya Food and Agriculture University
2024
Sağlık Bilimleri Üniversitesi
2024
Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative 20 days post-infection, but prolonged positivity has been reported up 63 days. A case whose viral shedding lasted 60 is from China. Herein we report a patient with history of autologous stem cell transplantation (ASCT) lymphoma RT-PCR remained positive 74 The positivity,...
During the ongoing COVID-19 pandemic due to SARS-CoV-2 virus of which evidence-based medical paradigms cannot be easily applied; difficult clinical decisions shall required particularly in 'difficult-to-treat' cases high risk group with associated comorbidities. Convalescent immune plasma therapy is a promising option as sort 'rescue' treatment syndrome, where miraculous antiviral drugs are not available yet. In this report, we aim convey our experience multi-task approach convalescent and...
Background: Venetoclax-based (ven) combinations have become a standard of care for acute myeloid leukemia (AML) patients ineligible intensive chemotherapy. However, the associated risk infectious adverse events (IAEs) remains significant clinical concern. Aims: This study aimed to evaluate incidence, characteristics, and factors IAEs in newly diagnosed AML treated with venetoclax real-world setting. Methods Results: We conducted retrospective cohort ven combination hypomethylating agents or...
As in the case of cancer, risk infection increases when host's immune system is not working properly. It has been shown that toxins produced by bacteria responsible for bacterial infections can alter properties cancer cells as well their sensitivity to chemotherapy agents. Staphylococcus aureus (S. aureus) one most prevalent pathogens acute myeloid leukemia (AML) patients and it produces several virulence factors, including Staphylococcal enterotoxin A (SEA) B (SEB). Cytotoxicity, transwell...
Background/aim: The disease caused by SARS-CoV-2 was named as COVID-19. There is yet insufficient information about the effects of HSCT on clinical course In present study, we aimed to investigate COVID-19 in patients who had undergone HSCT. Materials and methods: We analyzed baseline characteristics, findings COVID-19, hospitalization death rates, overall survival, case fatality rates recipients diagnosed with retrospectively. Results: 57.6% underwent AHSCT, 42.4% allo-HSCT. 60.6%, 27.3%,...
The SARS-CoV-2 spike protein mRNA-based vaccines have prevented countless mortality and morbidity, an excellent risk/benefit ratio. However, various adverse events may rarely occur after the BNT162b2 vaccine, like any other medical intervention. COVID-19 itself produced endogenously by mRNA immunological, microenvironmental, prothrombotic, neoplastic effects. As a contribution to published report, we would share our experience regarding four cases in which myeloid neoplasms emerged following...
To evaluate the incidence, clinical features, risk factors, and prognosis of central nervous system (CNS) involvement in patients with acute myeloid leukemia (AML).All AML who were admitted to Hacettepe University hospital between 2000 2021 evaluated. The medical records 548 cases retrospectively analyzed.The frequency CNS was 2.4% (n = 13) at diagnosis 4.6% 25) or during follow-up. Parenchymal seen 5 patients, leptomeningeal 11 patients. Three had both parenchymal involvements, 6 optic...
Background: Multicentric Castleman disease (MCD) is a rare, aggressive lymphoproliferative disorder. Human herpesvirus-8 (HHV-8) has an important role in the pathogenesis of and its association with Kaposi’s sarcoma been reported, especially people living human immunodeficiency virus (HIV). In this report, we present case HHV-8 positive MCD accompanied by multiple myeloma HIV-negative patient. Case Report: A 78-year-old man presented B symptoms, pancytopenia, lymphadenopathy, splenomegaly....
To the Editor,Approximately half of all acute myeloid leukemia (AML) patients eventually relapse after allogeneic stem cell transplantation (aHSCT) [1], and best treatment aHSCT is unclear.The present study sought to demonstrate outcomes combination venetoclax azacitidine (VEN-AZA) in with relapsed AML who were unsuitable for intensive regimens.This had a single-center, retrospective cohort design.The sample consisted treated at Hacettepe University Türkiye.Ethical approval was obtained from...
Tyrosine kinase inhibitors (TKis) and Bruton's TKi (BTKis) constitute broadly used antitumor drug groups with almost completely tolerable manageable side-effect profiles. Mainly side effects are cardiovascular gastrointestinal for the group. Hypophosphatemia is documented frequently in many studies TKis but rarely mentioned ibrutinib use up to present.A 61-year-old patient diagnosis of chronic lymphocytic leukemia had hypophosphatemia-related complaints symptoms when was preferred his second...
Objective: We aimed to delineate the effects of ABO groups and main clinical outcomes with current SARS-CoV-2 variants, i.e., delta omicron. Materials Methods: In this retrospective case-control study, total 360 adult COVID-19 patients who were followed in pandemic waves omicron variants had blood group analysis included divided into two according variant. Demographic characteristics, comorbidities, length hospitalization intensive care needs, survival cases recorded. These then compared...
In this multicenter retrospective study, we evaluated the efficiency on survival and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with relapse/refractory (R/R) Hodgkin lymphoma (HL) non-Hodgkin (NHL). A total 110 R/R HL or NHL who underwent allo-HSCT were between July 2007 October 2022 7 adult centers. The primary endpoints study progression-free (PFS), graft versus host disease-free, relapse-free (GRFS) overall (OS) after allo-SCT Forty-one (37.3%)...
To the Editor, Nilotinib, a second-generation tyrosine kinase inhibitor (TKI), is employed in treatment of chronic myeloid leukemia (CML) [1].However, previous studies have indicated an association between nilotinib and vascular adverse events, including peripheral arterial occlusive disease, cerebrovascular coronary artery disease [2,3].We report case significant bilateral carotid stenoses without any neurologic symptom and, at same time, left subclavian celiac atherosclerotic or...
Studies comparing the efficacy and safety of prophylactic regimens for central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL) are scarce adults. This multicenter retrospective study aimed to compare with without CNS irradiation on development relapse during follow-up.This was a comparative cohort study. A total 203 patients were included from four tertiary care centers Turkey. Patients divided into two groups according whether they received or not. The analyzed...