A5013415518- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Blood Coagulation and Thrombosis Mechanisms
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Ocular Diseases and Behçet’s Syndrome
- Hematological disorders and diagnostics
- Hemophilia Treatment and Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Childhood Cancer Survivors' Quality of Life
- Kruppel-like factors research
- Bone and Joint Diseases
- Peptidase Inhibition and Analysis
Hacettepe University
2015-2024
Palmetto Hematology Oncology
1996-2013
Hacettepe University Hospital
2008-2011
May Institute
2005
October 6 University
2005
COVID-19 (Coronavirus disease of 2019) is an infectious outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe failure. The clinical studies have shown that advanced age chronic diseases increase risk infection. However, influence blood groups infection its outcome remains to be confirmed. aim this study investigate whether there exists relationship between patients outcomes
The validity of the three currently used chronic myeloid leukemia (CML) scoring systems (Sokal CML prognostic system, Euro/Hasford and EUTOS system) were compared in patients receiving frontline imatinib mesylate.One hundred fourty-three phase (71 males, 72 females) taking as treatment included study. median age was 44 (16-82) years. Median total on-imatinib follow-up durations 29 (3.8-130) months 25 (3-125) months, respectively.The complete hematological response (CHR) rate at 3 95%. best...
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed presence molecular subtypes AML that are not accounted for by standard clinical parameters or routinely used biomarkers. Such predicted vary chemotherapy targeted therapy. The Renin-Angiotensin System (RAS) is an important group proteins play a critical role regulating blood pressure,...
Abstract The prevalence of genetic risk factors for thrombosis varies greatly in different parts the world, both patients with and general population. Factor V Leiden (FVL) prothrombin G20210A (PT G20210A) mutations are most common defects leading to thrombosis. We have previously reported that those two thrombotic alleles frequently found Turkish children aim present study was investigate frequency FVL PT their clinical manifestations adult Between January 1997 February 2000, 146 documented...
Two hundred and five patients referred for evaluation of platelet functions 126 healthy controls were tested with the PFA-100 instrument. A cut-off value 150 s collagen/epinephrine (CEPI) closure time (CT) produced most acceptable sensitivity (90%), specificity (85.2%), positive (82.6%) negative (91.6%) predictivity values screening function disorders von Willebrand disease (vWD). All vWD Glanzmann thrombasthenia could be detected by PFA-100. Both CEPI collagen/adenosine diphosphate (CADP)...
Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine affecting hematopoiesis. Angiotensin II type 1a (AT1a) receptors are present on the CD34+ hematopoietic stem cells. stimulates proliferation of and umbilical cord blood progenitors. There preliminary data that local RAS might also be involved in leukemogenesis. ACE hyper-function may lead to acceleration negative regulator peptide, AcSDKP, metabolism, which turn lowers its level micro-environment, finally removing...
Treatment of acute lymphoblastic leukemia is unsatisfactory in adults due to disease and patient-related factors probably because adult chemotherapy regimens are weaker than pediatric protocols. Worries about inadequacy urged many hematologists, including us, reconsider their routine treatment practices. In this retrospective multicenter study, we aimed evaluate results hyper-CVAD comparison other intensive All patients aged ≤65 years who were commenced on induction between 1999 2011...
The aim of this study was to assess bone marrow (BM) fibrosis and dysplasia in chronic myeloid leukemia (CML) patients receiving the first-generation tyrosine kinase inhibitor (TKI), imatinib, or second-generation TKIs, dasatinib, nilotinib. We further investigated whether CML under TKI is associated with dysplastic BM changes during clinicopathological course disease.In total, pre-treatment paraffin blocks biopsy specimens were available for 41 adult diagnosed phase CML. Post-treatment...
D A ) i s a f r e q u en t d o .A l , m y b g n rious diseases.Iron deficiency points to an occult or frank bleeding lesion when occurred in men postmenopausal women.In this study, we aimed evaluate the diagnostic yield of endoscopy patients with IDA and define predictive factors gastrointestinal (GI) lesions causing IDA.Ninety-one (77 women, 14 men; mean age: 43 years) who were decided have esophago-duodenoscopy and/or colonoscopy for iron anemia interviewed responded questionnaire that...
There are very few data about the relationship between acute myeloid leukemia (AML) prognosis and bone marrow recovery kinetics following chemotherapy. In this study, we aimed to assess prognostic importance clinical associations of neutrophil platelet rates rebound thrombocytosis (RT) or neutrophilia (RN) in postchemotherapy period for newly diagnosed AML patients. De novo patients October 2002 December 2013 were evaluated retrospectively. One hundred suitable inclusion. Cox regression...
The primary thrombocytosis (thrombocythemia) associated with myeloproliferative disorders is believed to be due autonomous platelet production. Secondary or reactive can observed in a number of clinical circumstances, and may related persistent overproduction some thrombocytopoietic factors acting on megakaryocytes. Several cytokines, including IL-6, IL-1 IL-4 have been shown act alone concert, affect various cellular stages megakaryocytopoiesis humans. aim this study assess the serum...
Myeloid sarcoma, formerly termed granulocytic sarcoma or chloroma, consists of neoplastic precursors and myeloblasts. Isolated chloromas (granulocytic sarcomas) are rare tumors. Spinal complications chloromas, such as cord compression secondary to epidural tumor cauda equine syndrome have been described but rare. We herein report two cases with spinal sarcomas in non-leukemic patients. The case a previously healthy 22-year-old man diagnosed multiple no evidence bone marrow other...
Objective: Multiple myeloma (MM) associated with extramedullary (EM) plasmacytoma has a poor therapeutic response and outcomes when treated conventional chemotherapy.EM is divided into two groups: the first group comprises tumors that are extending directly from osteolytic bone lesions (EM-B, bone-related), while second results infiltration soft tissues no relationship to (EM-S, tissuerelated).This study aimed compare general characteristics survival of transplant-eligible MM patients who...
Primary immune thrombocytopenia (ITP) is an acquired disorder of platelets with a complex and unclear mechanism increased destruction or impaired production platelets. While the management ITP evolving, there still need for guidance, particularly in certain circumstances such as pregnancy, emergencies, patients requiring co-medications. We aimed to determine tendencies hematologists Türkiye event special considerations.
There is preliminary evidence that the local renin-angiotensin system (RAS) could affect neoplastic hematopoiesis. The aim of this study to search messenger RNA (mRNA) expressions essential RAS elements in myeloid and lymphoid hematological disorders. Forty-six patients with newly diagnosed (AML, biphenotypic leukemia, CML) or (CLL, NHL, B-ALL, T-ALL) disorders were included study. In group, median expression values RENIN, ACE1, ACE2 ANGIOTENSINOGEN (ANGTS) mRNAs 1.96%, 0.42%, 0.00% 0.00%,...
Background/aim: Polycythemia Vera (PV) is a myeloproliferative disorder characterized by overproduction of morphologically normal red blood cells (RBCs), granulocytes, and platelets, phenotype that caused mutation (V617F) in Janus kinase 2 (JAK2). However, JAK2 V617F also found approximately 50% patients with essential thrombocytosis primary myelofibrosis, rendering its presence nonspecific as diagnostic test. An increased cell mass major criterion for the diagnosis PV according to World...