A5001187704- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Venous Thromboembolism Diagnosis and Management
- Bone and Joint Diseases
- Multiple Myeloma Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Blood properties and coagulation
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Ocular Diseases and Behçet’s Syndrome
- Cell Adhesion Molecules Research
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Glycosylation and Glycoproteins Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Proteoglycans and glycosaminoglycans research
- Liver Disease and Transplantation
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
Başkent University
2006-2023
Başkent University Hospital
2004-2021
Sivas Cumhuriyet Üniversitesi
2017
Palmetto Hematology Oncology
2007-2011
Gaziantep Children's Hospital
2011
Istanbul Kent University
2010
Turkish Society of Hypertension and Renal Diseases
2010
Hacettepe University
1998-2004
Bursa Uludağ Üni̇versi̇tesi̇
2003
The combination of melphalan–prednisone–thalidomide (MPT) has been investigated in several clinical studies that differed significantly with regard to patient characteristics and treatment schedules. This prospective trial differs from previous melphalan–prednisone (MP) vs. MPT trials by dosing, duration, routine anticoagulation, permission for a crossover. Newly diagnosed patients multiple myeloma (MM) (n = 122) aged greater than 55 yr, not eligible transplantation were randomized receive 8...
Two hundred and five patients referred for evaluation of platelet functions 126 healthy controls were tested with the PFA-100 instrument. A cut-off value 150 s collagen/epinephrine (CEPI) closure time (CT) produced most acceptable sensitivity (90%), specificity (85.2%), positive (82.6%) negative (91.6%) predictivity values screening function disorders von Willebrand disease (vWD). All vWD Glanzmann thrombasthenia could be detected by PFA-100. Both CEPI collagen/adenosine diphosphate (CADP)...
Anemia is a frequently observed manifestation during the clinical course of chronic liver disease. In this study, we retrospectively reviewed hospital files 500 disease patients and assessed frequency, etiology morphology anemia in 50 who fulfilled criteria to be included study. The mean age was 48 ± 16 years male/female ratio 1.4/1. hemoglobin value 9.54 2.03 g/dl. MCV 82.9 10.52 fl. Iron deficiency anemia, defined as absent bone marrow iron stores, most common present 50% patients....
Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) results of bone marrow samples 36 multiple myeloma (MM) patients at the time diagnosis have been evaluated. Three probes for chromosome 13q (RB1, D13S319, D13S25), one 14q32 (IgH) 17p13 (p53) used with fixed cells. Twenty (55.5%) had normal karyotypes, whereas eight (22.2%) numerical or structural chromosomal abnormalities. We did not find metaphases patients. Fluorescence analyses revealed least more abnormal 25...
The accompanying thrombocytosis is referred to as the major factor associated with thromboembolism in iron deficiency anemia (IDA). Increased viscosity may increase risk of thrombosis. We hypothesized that increased platelet count -with reactive thrombocytosis- might also affect plasma viscosity. planned evaluate influence normal and high on IDA patients.The patient population consisted fifty-three newly diagnosed untreated women aged between 18 62 years IDA. Group 1 33 patients, levels...
In the presence of a pathogenetic mutation in JAK2 or MPL, differential diagnosis essential thrombocythemia (ET) from reactive causes is relatively simple. However, patients with suspected ET who lack and MPL mutations, exclusion secondary especially important. The study was aimed to explore clinical application particularly mean platelet volume (MPV), hemoglobin, red blood cell indices, white cell, serum iron profile, C-reactive protein level thrombocytosis. Medical records 49 patients,...
Objective: Hemochromatosis is an autosomal recessive disease that one of the most important reasons for iron overload.Sickle cell a hemoglobinopathy occurs as result homozygous mutation in hemoglobin gene.Erythrocyte transfusion frequently used treatment this disease.Iron overload mortality and morbidity sickle anemia patients well other hemoglobinopathies.In study, effect hemochromatosis gene (HFE) p.H63D p.C282Y mutations on transfusion-related cardiac liver who carry S has been...
To the Editor, Since its approval in 1997 by US Food and Drug Administration, use of rituximab (MabThera®, Roche, Switzerland) has become widespread, especially for treatment non-Hodgkin lymphoma (NHL) chronic lymphocytic leukemia (CLL) [1]. Rituximab is a monoclonal chimeric antibody that targets CD20 antigen on surface normal B-cells malignant cells patients with B-cell lymphoproliferative disorders. The toxic effects are mild usually limited to initial administration [2]. Reactions...
In this study, we planned to investigate frequency of the JAK2 V617F mutation and it's relation with clinical laboratory findings BCR-ABL negative myeloproliferative diseases (MPD) which consist polycythemia vera (PV), essential thrombocythemia (ET) idiopathic myelofibrosis (IMF).Totally 65 patients were included in study composed 28 (43.1 %) PV, 29 (44 ET 8 (12.3 IMF patients.Forty one (63%) female 24 (37%) male.Mean age was 64.02±12.42.Frequency JAK2V617F found 25 (89.3%) 18 (62.1%) 2...
Introduction: The aim of this study is to assess circulating thrombopoietin concentrations in patients with both clonal and reactive thrombocytosis (RT), which are two distinct categories extreme platelet production circumstances. Investigation the levels versus may help us understand interactions key regulatory cytokine conditions abnormally increased formation exist.Materials methods: Thrombopoietin were measured counts greater than 500 × 103 μl−1 population consisted 21 RT (13 iron...
Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression acute lymphoblastic leukemia (ALL) cells well known: function or presence myeloblastic (AML) still largely unknown. The syndecan-1 was studied bone marrow biopsies three patients with AML using electron microscopic immunocytochemistry. Positive found cells. These results suggest that not only a characteristic phenotypic marker for ALL, but also
Basic fibroblast growth factor (bFGF) is an important involved in clonal hematopoietic expansion, neoangiogenesis, and bone marrow fibrosis, all of which are pathobiologic features chronic myeloproliferative disorders (CMPD) myelodysplastic syndromes (MDS). The aim this study was to assess circulating bFGF concentrations patients with CMPD MDS respect the presence fibrosis histopathologic examination. group comprised 18 (six female, 12 male; median age 50 years), seven (one six 66 years) 10...
Diabetes mellitus is considered to cause a tendency for arterial thrombosis. Recent studies addressed the association between venous and disease. Resistance activated protein C one of most common causes thrombosis linked single point mutation in factor V gene, designated as Leiden mutation. There little information regarding status type 1 diabetes. The aim this study evaluate among sensitivity ratio, mutation, diabetes taking into account metabolic control, lipids diabetic complications....
The aim of this study is to evaluate the etiology and features anemia in elderly patients from perspective hematology determine rate unexplained anemia. medical records over age 65 who applied Hematology Department Ankara Baskent University Hospital between January 2015 2020 were retrospectively analyzed. According WHO criteria, threshold value accepted for was Hb <12 g/dL women <13 men. prevalence 18% among 3330 patients. ratio men diagnosed with 1.5:1, mean 77.34±8.32....