A5037934805- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Hepatitis C virus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Hemoglobinopathies and Related Disorders
- Neutropenia and Cancer Infections
- Autoimmune Bullous Skin Diseases
- Microfluidic and Bio-sensing Technologies
- Pneumocystis jirovecii pneumonia detection and treatment
- Galectins and Cancer Biology
- Hematological disorders and diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Erythrocyte Function and Pathophysiology
- Antifungal resistance and susceptibility
- Immunodeficiency and Autoimmune Disorders
- Fungal Infections and Studies
Marmara University
2004-2024
Yeditepe University Hospital
2014
Procter & Gamble (Germany)
1998
POEMS syndrome with its classical five findings (Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin changes) is a rare multisystem disease. Proinflammatory proangiogenic cytokines play important roles in pathogenesis. Treatment options are still debated.We present 65-year-old man who was successfully treated bortezomib.After seven cycles of this protocol, serum protein level declined to normal range, near-to-complete remission achieved. His symptoms polyneuropathy improved...
In general, tuberculosis (Tb) is rarely seen in allogeneic stem cell transplant (alloSCT) recipients, but this observation has been challenged developing countries such as Turkey, where Tb infection more prevalent than Europe and the US.In retrospective study, we report on incidence of infections 351 alloSCT recipients at 4 bone marrow transplantation units Turkey over last 10 years.The frequency after allografting (5 351) was far greater that general population (35.4 per 100,000).Of...
Abstract Background Chemotherapy‐induced acral erythema is a distinct localized cutaneous response to certain systemic chemotherapeutic agents. Methods Between January 1990 and December 1994, from total of 76 leukemic patients who have received combination chemotherapy consisting cytosine arabinoside anthracycline antibiotics, 15 developed chemotherapy‐induced erythema. Fourteen the had acute myelocytic leukemia, one them chronic myelogenous leukemia in blast phase. Clinical features these...
Fifty‐seven adult patients with idiopathic thrombocytopenic purpura (ITP) were treated either conventional‐dose prednisolone (CDP) (1 mg/kg/d, 36 patients) or high‐dose methylprednisolone (HDP) (30 21 patients), as first‐line treatment. Patients in the HDP arm responded more rapidly (4.7 v 8.4 d), a higher response rate (80% 52.7%), and without severe side‐effects. One quarter of (3/12) who non‐responsive to CDP achieved complete remission when they HDP. The findings suggest that may be...
Chemical alterations of red blood cells (RBCs) during storage eventually affect the electrical properties blood. In this study, physiological parameters such as extracellular (SAGM + CPD residual plasma) Na+, K+, Cl−, pH, 2,3-DPG and ATP together with Cole-Cole were measured using erythrocyte suspensions from 51 male donors (31 form training set 20 are used for testing), on 0th, 10th, 21st, 35th 42nd days storage. During storage, while surrounding fluid resistance (Re) effective cell...
The renin–angiotensin system (RAS) is involved in cell growth, proliferation and differentiation bone marrow an autocrine–paracrine manner, it modulates normal neoplastic haematopoietic proliferation. This study aimed to assess expressions of the RAS components, renin, angiotensinogen angiotensin-converting enzyme (ACE), during imatinib mesylate treatment patients with chronic myeloid leukaemia (CML). Expressions components were studied CML at time diagnosis ( n = 83) 3, 6 12 months after...
This observational study attempted to identify the effect of a natural disaster on safety blood supply and donor types with influx donors after severe earthquake. Blood donation rate, discard rate donations responding earthquake, as projected from infectious disease marker were evaluated in donated immediately before (1 July-17 August) 17 August 1999 (17 August-21 August). These compared results corresponding periods 1998 2000 for at university medical centre two regional centres. 8055 units...
Background: B-chronic lymphocytic leukemia (B-CLL) is characterized by accumulation of CD5+ B lymphocytes. Decreased VLA-4 (Cd49d/CD29) and CD11a expression defective adhesion in B-CLL have been previously shown, although there was no substantial data about its importance immunobiology B-CLL. The hepatocyte growth factor (HGF) receptor, c-met, plays a role acting on VLA-4. c-met share crucial signaling molecules cell survival. In this study, relationship between expressions CD49d, CD11a,...
Cyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes conversion of arachidonic acid into prostaglandins and contributes to inflammatory process. Cyclooxygenase-2 (cox-2), one two isoforms, plays a role in tumor progression carcinogenesis. p53 apoptosis, DNA renewal cell cycle. Studies concerning relationship cox-2 expressions carcinogenesis are available, but association between Hodgkin lymphoma (HL) not exactly known.In our study, we examined expression, with age, stage,...
Renal failure is a common manifestation of multiple myeloma (MM). Bortezomib primarily metabolized by cytochrome p450 isoforms. It also has cytochrome-independent metabolism excretion through the bile and kidney. Based on our observations, we aimed to explore efficacy toxicity profiles bortezomib in 56 patients with MM, 24 which had moderate severe renal failure. Overall response complete response, as well very good partial rates, were comparable between normal functions impairment. The...
Eosinophilic fasciitis is an uncommon connective tissue disease that may mimic and overlap with other sclerosing disorders such as morphea lichen sclerosus.Herein, we report four patients (two men two women, aged 16-64 yeas) eosinophilic fasciitis.There was both sclerosus in 2 morphoea alone 1 patient.Magnetic resonance imaging (MRI) used for diagnosis three assessing treatment response one patient.Eosinophilic co-exist morhoea sclerosus.In view of the overlapping clinical histopathological...
Objective: The aim of this study was to assess the prognostic value CD49d expression in Turkish chronic lymphocytic leukemia patients.Material and Methods: Data for 118 patients from a single center were evaluated.In all, included 73 whom complete clinical follow-up data, flow cytometry test results CD5/19, CD23/43, CD38, Zap-70, Kappa, Lambda light chains, available.The effect level on overall survival (OS) time treatment (TTT) investigated retrospectively.Results: Patients with high (≥30%)...