A5008911553- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Proteoglycans and glycosaminoglycans research
- Hemophilia Treatment and Research
- Hematopoietic Stem Cell Transplantation
- Hemostasis and retained surgical items
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Hematological disorders and diagnostics
- Blood properties and coagulation
- Fungal Infections and Studies
- CNS Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
Gaziantep University
2025
Bahçeşehir University
2017-2024
Marmara University
2002-2014
Loyola University Medical Center
2007-2011
Loyola University Chicago
2008
Thrombin and factor Xa play a central role in thrombogenesis both medical surgical patients. Antithrombin (AT) is the key inhibitor, which controls action of these enzymes hypercoagulable states. The AT concentrates prepared from human blood have been used to treat patients with thrombotic disorders heparin resistance. are pooled plasma beside limited supply, suffer viral other biological contaminants. availability recombinant (rhAT) obtained genetically engineered goats provide biologically...
The renin–angiotensin system (RAS) is involved in cell growth, proliferation and differentiation bone marrow an autocrine–paracrine manner, it modulates normal neoplastic haematopoietic proliferation. This study aimed to assess expressions of the RAS components, renin, angiotensinogen angiotensin-converting enzyme (ACE), during imatinib mesylate treatment patients with chronic myeloid leukaemia (CML). Expressions components were studied CML at time diagnosis ( n = 83) 3, 6 12 months after...
BK-virus (BKV) is an important etiological agent for late-onset hemorrhagic cystitis (HC) in patients undergoing hematopoietic stem cell transplantation. Late-onset HC causes significant morbidity among these patients. Therapeutic approaches remain predominantly symptomatic. Several treatment options have been used with variable success rates. Cidofovir has the highest specificity against BKV; however, its lack of availability majority countries, high costs and potential nephrotoxic effects...
A 65‐year‐old woman with essential thrombocythemia (ET) had been taking oral hydroxyurea (HU), 1000 mg daily, for 7 years. Six months ago, she developed an ulcer on the outer part of her left ankle, which healed spontaneously within 2 months. She presented a new, tender, shallow ulcer, cm × in size, at same site. Doppler examination revealed thrombosis common femoral vein and calcified atheroma plaque artery. The dosage HU was decreased to 500 daily when platelet counts were found be normal...
Sulodexide represents a novel antithrombotic agent with multiple sites of action on blood coagulation and vascular processes. The purpose this study was to compare sulodexide enoxaparin anticoagulant effects, tissue factor (TF)-induced activation platelets, inhibition microparticle generation investigate their effect heparin-induced platelet aggregation (HIPA). compared at equigravimetric concentrations. When enoxaparin, produced stronger in the prothrombin time (PT), activated partial...
The prevention of venous thromboembolism has been identified as a leading priority in hospital safety. Recommended parenteral anticoagulant agents with different indications for the and treatment include unfractionated heparin, low-molecular-weight heparins fondaparinux. Prescribing decisions management may seem complex due to large range clinical patient types, anticoagulants available.
During the period of November 2007 to January 2008, an increased prevalence adverse reactions heparin was noted. These events have been attributed presence purposeful contaminant, oversulfated chondroitin sulfate (OSCS) from April May 2008. An analysis dialysis patients' plasma obtained in 2006 and consistently had a low (5%) AHPF4 antibodies. Blood samples 78 patients on maintenance hemodialysis, who were potentially exposed OSCS-contaminated heparin, analyzed for all antibodies using...
A patient with idiopathic myelofibrosis nephrotic syndrome is reported. Seven months after the initial diagnosis of myelofibrosis, was presented dyspnea, generalized edema, heavy proteinuria, massive pleural effusion, and ascites. Renal biopsy showed focal segmental glomerulosclerosis. After starting immunosuppressive therapy consisting cyclosporine steroids, his renal function proteinuria improved transfusion requirements decreased.
Introduction In this study, we profiled the levels of blood cellular indices, endogenous glycosaminoglycans (GAGs) and inflammatory biomarkers in a cohort comprised pulmonary embolism (PE) patients, to determine their inter-relationships. Identification relationship may provide insight complex pathophysiology PE predictive role indices acute patients. Materials Methods Plasma samples from patients healthy controls were analyzed for thrombo-inflammatory (IL-2, IL-4, IL-6, IL-8, IL-10, VEGF,...
Onychomycosis (OM) is a common fungal infection of the toenails and/or fingernails that highly prevalent in general population and also responsible for significant morbidity. OM caused by dermatophytes, nondermatophytic molds, or yeast. Today systemic antifungal agents are considered as gold standard all types OM. Here we report case aplastic anemia associated with oral terbinafine use review literature on hematological toxicities terbinafine. Onikomikoz el ve ayak tırnaklarının sık görülen...
Low-molecular-weight heparins (LMWHs) are poly-pharmacologic drugs used to treat thrombotic and cardiovascular disorders. Recently, several generic versions of branded LMWHs have been introduced. Although exhibit similar profiles, marked differences in their biological pharmacologic properties demonstrated. Several studies demonstrated terms anti-Xa activity tissue factor pathway inhibitor release. The current data emphasize the need consider multiple functional parameters when defining...
2553 Background: Small Cell Lung Carcinoma (SCLC) patients exhibit a higher prevalence of thromboembolic complications. We hypothesized that in this malignancy, procoagulant and inflammatory mediators contribute to the pathogenesis such complications warfarin may down regulate these levels. Methods: In prospective, randomized, controlled study, with inoperable lung cancer (n=100) were randomized receive chemotherapy radiation without (INR 1.5 – 2.5). Blood samples drawn prior after 2nd...