A5061452698- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Cellular Mechanics and Interactions
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Click Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Chemical Synthesis and Analysis
- Immune Cell Function and Interaction
- Advanced Drug Delivery Systems
- CAR-T cell therapy research
- Fibroblast Growth Factor Research
- Autoimmune and Inflammatory Disorders
- Advanced biosensing and bioanalysis techniques
- Macrophage Migration Inhibitory Factor
- Autoimmune Bullous Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- Long-Term Effects of COVID-19
Hacettepe University Hospital
2020-2025
Cancer Institute (WIA)
2020-2025
Hacettepe University
2020-2021
Izmir Institute of Technology
2020
K-RAS is a highly relevant oncogene that mutated in approximately 90% of pancreatic cancers and 20-25% lung adenocarcinomas. The aim this work was to develop new anti-KRAS siRNA therapeutic strategy through the engineering functionalized lipid nanoparticles (LNPs). To do this, first, potent pan sequence chosen from literature different chemical modifications were tested for their transfection efficacy (KRAS knockdown) anti-proliferative effects on various cancer cell lines. Second, selected...
Idiopathic Granulomatous Mastitis (IGM) is a benign chronic inflammatory breast disease that mimics cancer, and the etiopathogenesis has not yet been fully evaluated. Autoimmunity received most focus as possible etiology. Our aim in this prospective clinical study was to investigate association between cytokines, interleukin IL-17, IL-22, IL-23 IGM.The current conducted 26 women with histopathologically diagnosed IGM, 15 control of reproductive age having no history. Blood samples were...
In contrast to the mouse, functional assets of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) in human spleen remain be better elucidated. Here, we report that gastric and pancreatic cancer adopts an immune regulatory character, harbors excessive amount PMN-MDSC, anatomically enables their interaction with T cells. Compared peripheral blood, from patients contained significantly higher levels low-density but not early-stage MDSC (e-MDSC) monocytic-MDSC (M-MDSC). Low-density...
Small cell lung cancer (SCLC) is an aggressive tumor type with early dissemination and distant metastasis capacity. Even though optimal chemotherapy responses are observed initially in many patients, therapy resistance almost inevitable. Accordingly, SCLC has been regarded as archetype for stem (CSC) dynamics. To determine the immune-modulatory influence of CSC SCLC, this study focused on characterization CD44+CD90+ CSC-like subpopulations SCLC. These cells displayed mesenchymal properties,...
Inflammatory alterations of the extracellular matrix shape tumor microenvironment and promote all stages carcinogenesis. This study aims to determine impact cellular fibronectin on inflammatory facets tumor-associated macrophages (TAMs) in breast cancer. Cellular (FN) harboring alternatively spliced extra domain A (FN-EDA) was determined be a component produced by triple-negative cancer (TNBC) cells. High levels FN-EDA correlated with poor survival patients. The proinflammatory cytokine...
This study evaluates the functional capacity of CD4+ and CD8+ terminally-differentiated effector (TEMRA), central memory (TCM), (TEM) cells obtained from volunteers vaccinated with an aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac). The were followed for T cell immune responses following termination a randomized phase III clinical trial. Seven days four months after second dose vaccine, subsets collected stimulated by autologous monocyte-derived dendritic (mDCs)...
Immune checkpoint inhibitor (ICI) immunotherapy relies on the restoration of T-cell functions. The ICI receptors are not only found exhausted T cells but also upregulated upon activation and reach high levels effector cells. In an ex vivo model, this study explored consequences PD-1 cytotoxic T-lymphocyte antigen (CTLA-4) blockade applied during specific time frames stimulation that coincide with distinct functional phases in type 1 helper (Th1) When at early stage, interfered upregulation...
Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth factor (EGF) produced by colony stimulating factor-1 (CSF-1) BCC. Despite contradictory findings, this interaction is perceived as a paracrine loop. Further, the underlying mechanism of remains unclear. Here, we investigated interactions BCC with in 2D 3D. did not show chemotaxis custom designed 3D cell-on-a-chip devices, which was agreement ELISA results showing that macrophage-derived-EGF secreted into...
Tumor cells benefit from some certain signals, which are referred to as “immune checkpoints”, escape immune-mediated destruction. With that in mind, it is believed the blockade of these points, such programmed cell death Ligand-1 (PD-L1) and 1 (PD-1), can restore an adaptative immune response against tumoral cells. In this study, we have designed synthesized novel peptidomimetics with a 2-aminobenzathiazole scaffold, targets PD-1/PDL-1 pathway. viability assay, was found compounds decreased...
Generating memory T cell responses besides humoral immune is essential when it comes to the efficacy of a vaccine. In this study, presence after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4+ CD8+ proliferation IFN-γ production capacities evaluated. Additionally, clinical frailty scale (CFS) FRAIL scales scored. more prominent than cells. individuals, 80% them had IFN-γ, whereas 50% all...
Aim: The differential diagnosis of benign and malignant diseases the thyroid is important in borderline malignancies that have not been diagnosed with biopsy. This study aimed to determine endocan molecule levels patients cancer, nodular goiter thyroiditis. Thus, it was availability diseases. Material Method: conducted between March 1, 2018 August 2018. During this period, who were scheduled for surgery due disease wanted participate voluntarily included study. A prospective, cross-sectional...
Tumor cells benefit from some certain signals, which are referred to as "immune checkpoints", escape immune-mediated destruction.With that in mind, it is believed the blockade of these points, such programmed cell death Ligand-1 (PD-L1) and 1 (PD-1), can restore an adaptative immune response against tumoral cells.In this study, we have designed synthesized novel peptidomimetics with a 2-aminobenzathiazole scaffold, targets PD-1/PDL-1 pathway.In viability assay, was found compounds decreased...
Tumor cells benefit from some certain signals, which are referred to as “immune checkpoints”, escape immune-mediated destruction. With that in mind, it is believed the blockade of these points, such programmed cell death Ligand-1 (PD-L1) and 1 (PD-1), can restore an adaptative immune response against tumoral cells. In this study, we have designed synthesized novel peptidomimetics with a 2-aminobenzathiazole scaffold, targets PD-1/PDL-1 pathway. viability assay, was found compounds decreased...