A5075552215- Long-Term Effects of COVID-19
- COVID-19 impact on air quality
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 epidemiological studies
- Respiratory Support and Mechanisms
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Extracellular vesicles in disease
- Infection Control and Ventilation
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Cystic Fibrosis Research Advances
- Inflammasome and immune disorders
- Tissue Engineering and Regenerative Medicine
- Biopolymer Synthesis and Applications
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 detection and testing
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Congenital Diaphragmatic Hernia Studies
- SARS-CoV-2 and COVID-19 Research
Koç University
2019-2024
Abstract Extravasation of monocytes into tissue and to the site injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) proteins. Protein arginine methyltransferase 7 (PRMT7) an epigenetic factor that has capacity mono-methylate histones on residues. Here we show in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression elevated lung localized macrophages. In mouse models COPD, fibrosis skin injury, reduced...
Air pollution plays an important role in the mortality and morbidity of chronic airway diseases, such as asthma obstructive pulmonary disease (COPD). Particulate matter (PM) is a significant fraction air pollutants, studies have demonstrated that it can cause inflammation injury. The epithelium forms first barrier defense against inhaled toxicants, PM. Airway epithelial cells clear airways from irritants orchestrate inflammatory response to these by secreting various lipid mediators, growth...
Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) associated with these conditions may influence the prognosis of adults COVID-19. Objectives: To determine effect OSA on clinical outcomes patients Methods: The current prospective observational study was conducted three hospitals Istanbul, Turkey from March 10 June 22, 2020. participants were categorized as high-risk...
Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease. Although cigarette smoke was considered the main cause of development, heterogeneous nature leaves it unclear whether other factors contribute to predisposition or impaired regeneration response observed. Recently, epigenetic modification has emerged be key player in pathogenesis COPD. The addition methyl groups arginine residues both histone and nonhistone proteins by protein methyltransferases (PRMTs) an...
Background Although studies suggest a deficiency in stem cell numbers chronic airway diseases such as obstructive pulmonary disease (COPD), the role of bronchial epithelial progenitor/stem (P/S) cells is not clear. The objectives this study were to investigate expression markers, cytokeratin (CK) 5, CK14 and p63 explants cultures obtained from smokers with without COPD following multiple outgrowths, effect on (BEC) proliferation. Methods Bronchial dissected lung cultured coverslips....
The multisystemic effects of COVID-19 may continue for a longer time period following the acute phase, depending on severity disease. However, long-term systemic transcriptomic changes associated with disease and impact are not fully understood. We aimed to investigate its alterations in peripheral blood mononuclear cells (PBMCs) 1 year PBMCs were isolated from healthy control donors who did have (C; n = 13), patients without pneumonia (NP; 11), severe (SP; 10) after 1-year follow-up....
Summary Chronic airway diseases, such as Obstructive Pulmonary Disease (COPD) and asthma pose a significant global health burden. The pathophysiology involves chronic inflammation, with oxidative stress playing crucial role in disease severity. Current treatments, especially for COPD, have limitations, necessitating exploration of alternative therapeutic approaches. In this study, we investigated the potential effects butyrate, short-chain fatty acid, on epithelial cells. Human bronchial...
Increased oxidative stress, epithelial permeability and cell viability play an important role in the pathogenesis of chronic airway diseases such as asthma obstructive pulmonary disease. Studies suggest that short-chain fatty acids butyrate may have regulatory effects at cellular level. We investigated hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) on trans-epithelial electrical resistance (TEER) A549 cultures. cells were cultured semi-permeable culture inserts, treated with 0, 100, 300, 600...
Reactive nitrogen species (RNS) such as nitric oxide (NO) can be produced by local pulmonary cells and inflammatory cells, they play a role in the pathogenesis of chronic diseases infections. NO is an unstable compound turning to more stable nitrite nitrate rapidly. The objective our study was investigate association between plasma nitrate+nitrite, nitrate, levels severity coronavirus disease (COVID)-19. Blood samples mild, moderate, severe COVID-19 patients were collected from 2 different...
Abstract Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus and has been affecting world since end of 2019. Turkey severely affected with first case being reported on March 11 th 2020. Ambient particulate matter (PM) samples in various size ranges were collected from 13 sites including urban background locations hospital gardens 10 cities across between May 14 June, 2020 to investigate a possible presence RNA ambient PM. A total 155 daily (TSP, n=80 ; PM 2.5 , n=33 2.5-10...
Primary ciliary dyskinesia is a rare genetic ciliopathy characterized by impaired clearance of the airway, leading to recurrent airway infections and various pulmonary conditions. The underlying cause PCD complex involves diverse mechanisms. On one hand, advancements in analysis techniques have significantly contributed identifying mutated genes associated with PCD, which turn, can aid understanding variable clinical presentations disease. other based on gene, disease manifestation may...
Abstract Long-COVID-19 manifests as a multisystemic condition with varied symptoms lingering beyond three weeks of acute SARS-CoV-2 infection, though its underlying mechanisms remain elusive. Aiming to decipher the long-term molecular impacts COVID-19, we conducted transcriptomic analysis on PBMCs from 1-year post-covid patients, including individuals without pneumonia (NP, n=10), those severe (SP, n=11), and healthy controls (C, n=13). Our extensive RNA sequencing revealed 4843...
RATIONALE: Coronavirus disease 2019 (COVID-19), which is caused by the SARS-CoV-2, has been affecting world since end of 2019. Turkey severely affected with first case being reported on March 11th 2020. Several studies suggest an association between air pollution and spread infection, that ambient particulate matters (PM) can present a potential, as virus carriers. The aim study was to investigate presence SARS-CoV-2 RNA PM. METHODS: Ambient PM samples in various size ranges were collected...
Coronavirus disease 2019 (COVID-19), which is caused by the novel coronavirus SARS-CoV-2 became a pandemic at beginning of 2020. Turkey has seriously been affected with more than 2 million cases as 08.02.2021. Previous studies suggested that ambient particulate matter (PM) may carry virus. The objective this study was to investigate RNA on PMs collected from 13 sites including hospital gardens, urban and background locations in 10 cities Turkey, between May June 14, Quantitative real...