A5107538613- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Thyroid Cancer Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Respiratory Support and Mechanisms
- Pituitary Gland Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vitamin D Research Studies
- Obesity, Physical Activity, Diet
Koç University
2021-2024
Istanbul University
2009-2022
Ministry of Health
2014
There is concern about an emerging diabetes epidemic in Turkey. We aimed to determine the prevalence of diagnosed and undiagnosed diabetes, prediabetes their 12-year trends identify risk factors for adult Turkish population. A cross-sectional, population-based survey, 'TURDEP-II' included 26,499 randomly sampled adults aged ≥ 20 years (response rate: 87 %). Fasting glucose biochemical parameters were measured all; then a OGTT was performed eligible participants. The 16.5 % (new 7.5 %),...
OBJECTIVES—To investigate for the first time prevalence of diabetes and impaired glucose tolerance (IGT) nationwide in Turkey; to assess regional variations relationships between intolerance lifestyle physical risk factors. RESEARCH DESIGN AND METHODS—The Turkish Diabetes Epidemiology Study (TURDEP) is a cross-sectional, population-based survey that included 24,788 subjects (age ≥20 years, women 55%, response 85%). Glucose was classified according World Health Organization recommendations on...
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order simplify the diagnostic tests compared with 2-hour oral tolerance test (OGTT; 2-hPG). We aimed identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey Turkey (TURDEP-II). The study included 26,499 adult (63% women, response rate 85%). mean serum...
Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development diabetes. To define determinants insulin resistance (IR) we investigated 73 genes involved BCAA metabolism or regulation by fine-scale haplotype mapping two European populations with metabolic syndrome. French Romanians (n = 465) were genotyped SNPs (Affymetrix) enriched imputation (BEAGLE 4.1) at...
Maturity-onset diabetes of the young (MODY) is a highly heterogeneous group monogenic and nonautoimmune diseases. Misdiagnosis MODY widespread problem about 5% patients with type 2 mellitus nearly 10% 1 may actually have MODY. Using next-generation DNA sequencing (NGS) to facilitate accurate diagnosis MODY, this study investigated mutations in 13 genes (HNF4A, GCK, HNF1A, PDX1, HNF1B, NEUROD1, KLF11, CEL, PAX4, INS, BLK, ABCC8, KCNJ11). In addition, we comprehensively clinical phenotypic...
Posttransplantation diabetes mellitus (PTDM) is a metabolic complication of renal transplantation. A high prevalence DM has been recently reported in patients with chronic hepatitis C virus (HCV) infection the nontransplant population. The aim this study was to investigate possible factors that may have role development DM, including HCV transplant recipients.This case-control included 43 PTDM (36 men, 7 women; mean age, 44+/-10 years) and consecutive who did not develop (30 13 37+/-11...
Diabetes is a common disorder with heterogeneous clinical presentation and an enormous burden on health care worldwide. About 1–6% of patients diabetes suffer from maturity-onset the young (MODY), most form monogenic autosomal dominant inheritance. MODY genetically clinically caused by genetic variations in pancreatic β-cell development insulin secretion. We report here new findings targeted next-generation sequencing (NGS) 13 MODY-related genes. A sample 22 unrelated pediatric healthy...
Abstract Objective: To evaluate long-term effects of COVID-19, and to determine the risk factors in long-COVID a cohort Turkish Thoracic Society (TTS)-TURCOVID multicenter registry. Methods: Thirteen centers participated with 831 patients; 504 patients were enrolled after exclusions. The study was designed three-steps: (1) Phone questionnaire; (2) retrospective evaluation medical records; (3) face-to-face visit. Results: In first step, 93.5% hospitalized; 61.7% had history pneumonia at time...
Alström syndrome is a rare, autosomal recessive disorder characterized by wide spectrum of clinical features including early‐onset retinal degeneration leading to blindness, sensorineural hearing loss, short stature, obesity, type 2 diabetes, hyperlipidemia and dilated cardiomyopathy. Renal, hepatic pulmonary dysfunction may occur in the later phases disease. The three affected sisters, from consanguineous Turkish family, with characteristic syndrome, were clinically diagnosed 1987 followed...
Multidrug-resistant pulmonary tuberculosis (MDRTB), a major problem in developing countries, may result from either insufficiency of host cellular immune response or mycobacterial mechanisms which has been more intensively investigated so far.The aim the study was to investigate natural killer cell activity (NKA) and T lymphocyte subsets HIV- patients with secondary MDRTB.20 male MDRTB (mean age 38 +/- 8 years), 15 nonresistant (NRTB) 36 11 years) 12 healthy controls 35 were included. The...
Branched-chained amino acids (BCAA) are essential dietary components for humans and can act as potential biomarkers diabetes development. To efficiently estimate intake, we developed a BCAA database 1331 food items found in the French Centre d’Information sur la Qualité des Aliments (CIQUAL) table by compiling content from international tables, published measurements, or similarity well calculating 267 Greek, Turkish, Romanian, Moroccan mixed dishes. The embedded MEDIPAD software capable of...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Liver biopsy is the standard in diagnosing liver diseases. Yet, it provides little space to perform comprehensive immune profiling of liver. Hence, we explored whether fine needle aspirates (FNAs) could be used elucidate hepatic immunity children.We enrolled 74 children undergoing diagnostic (n = 17) or protocol 57) following transplantation (LT). Matched blood and FNAs were obtained. Additionally, explant tissue was collected from 14) LT. Immune cells isolated peripheral blood, explanted...
<h3>Abstract</h3> Background/Aim: High-sensitivity C-reactive protein (hs-CRP) is used in the differential diagnosis of maturity-onset diabetes young (MODY)-3, but other inflammatory markers have not been investigated MODY patients. We aimed to compare serum levels anti-inflammatory and proinflammatory cytokines between patients healthy subjects show features subtypes. Patients Methods: Thirty with clinically suspected 34 controls were included this study. Next-generation sequencing (NGS)...