Rheumatic valvular disease has been reported to be associated with HLA antigens. To determine whether genetic factors could involved in the pathogenesis of rheumatic heart (RHD), we analyzed distribution HLA-A, HLA-B, and HLA-DR antigens Turkish patients chronic disease.The association class I II was examined 107 ethnic RHD. The diagnosis supported by echocardiography, cardiac catheterization, angioventriculography, histological findings who underwent valve replacement. Two hundred three...

Posttransplantation diabetes mellitus (PTDM) is a metabolic complication of renal transplantation. A high prevalence DM has been recently reported in patients with chronic hepatitis C virus (HCV) infection the nontransplant population. The aim this study was to investigate possible factors that may have role development DM, including HCV transplant recipients.This case-control included 43 PTDM (36 men, 7 women; mean age, 44+/-10 years) and consecutive who did not develop (30 13 37+/-11...

Due to inadequate cadaveric and living related organ supply, many end-stage renal disease patients go third-world countries for unrelated (paid) kidney transplantation. Thirty-four who have had transplantations in two centres India before coming our centre post-transplant care follow-up are reported this study. In the phase at centre, mean period of was 209.7±137.3 (range 6—450) days. Fourteen them, having an uneventful course, were followed on outpatient clinic basis. The rest hospitalized...

This study has been designed to investigate the immunogenetic susceptibility of Cyclosporine-A (CsA) immunosuppressed renal transplant patients development gingival overgrowth, and amplifying effect calcium channel blockers on severity this clinical entity. 52 recipients were selected initially grouped as follows: group (Gp)1: CsA (n = 7); Gp 2: + verapamil 26); 3: diltiazem 6); 4: nifedipine 13). These groups not found be significantly different in age, sex, plaque index (PlI), (GI),...

In this study, blood samples were taken from 200 patients with childhood acute leukaemias, including lymphoblastic leukaemia (ALL) and myeloid (AML), 100 healthy volunteers (controls). The frequency of the human leucocyte antigen (HLA)-DRB1*04 allele was significantly higher, frequencies HLA-A23 HLA-B7 antigens lower, in ALL compared controls. Among AML, HLA-B49 HLA-DRB1*15 whereas HLA-A11 HLA-B38 lower HLA-DRB1*04 also higher male HLA-DRB1*13 found less frequently AML female than To date,...

Cyclosporine A (CsA) and verapamil are two agents used in renal transplantation, both of which suspected inducing gingival overgrowth. This study was conducted to investigate the effect on severity prevalence CsA-induced Fifty-one (51) transplant recipients (total group) whom 22 were using only CsA (Group A) 29 prescribed + B) evaluated for various periodontal pharmacological parameters. No statistically significant differences found age, sex, plaque index, calculus probing depth, oral dose,...

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients controls were investigated a sample Turkish population. B27 subtyping was performed by PCR-SSP method two groups: 49 unrelated positive with diagnosis SpA according to European Spondyloarthropathy Study Group Criteria, 55 healthy controls. HLA-B*27 2.6% population, B*2705 predominant allele among SpA. difference mainly between male proportion B27-positive significantly different (P=0.02). Our study...

Summary Only a small fraction of the streptococcal pharyngitis progress to rheumatic carditis, which implies that environmental, host and microbial factors interact cause an aberrant immune response against antigens microorganism cross‐react with cardiac tissues. Although there are numerous studies general consensus on relation between human leucocyte antigen (HLA) class II heart disease (RHD), details culprit still controversial. The study was undertaken examine 100 patients chronic RHD...

Abstract The aim of the study was to investigate whether human leukocyte antigen (HLA) allele sharing between partners or maternal killer immunoglobulin‐like receptor (KIR) repertoire is associated with recurrent spontaneous abortion (RSA) and repeated implantation failure after in vitro fertilization (IVF)/embryo transfer. From a total population 158 RSA couples, 40 couples failures (IVF) 81 control reported by five different laboratories, analysis performed for (a) HLA 50 RSA, 31 IVF (b)...

The macronuclear rRNA genes of Tetrahymenathermophila contain an 0.4 kb intervening sequence in the 26S coding region. is represented within primary transcription product. We demonstrate this paper that enzyme activities necessary for endonucleolytic cleavage as well ligation transcript are associated with isolated nucleoli. Both these processes occur posttranscriptionally. excised unique molecule, which stable vitro. About 50% vitro synthesized RNA processed. Faithful occurs presence...

‘Immunogenetics of Aging’ is a component that was first included in the 14th International HLA and Immunogenetics Workshop (IHIWS) developed further within 15th Workshop. The aim this to assess impact human leukocyte antigen (HLA) genes, cytokine some innate immunity genes such as killer‐cell immunoglobulin‐like receptors (KIRs) mannose‐binding lectin 2 (MBL2) successful aging their contribution better understanding immune dysfunction old age. Within IHIWS new populations were analysis....

The aim of this study was to explore the association between polymorphisms five cytokine genes and clinical parameters in patients with Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) treated imatinib. We analyzed (interleukin [IL]-6, IL-10, gamma interferon [IFN-γ], transforming growth factor beta-1 [TGF-β1], tumor necrosis factor-alpha [TNF-α]) 60 cases Ph+ CML 74 healthy controls. Cytokine genotyping performed by polymerase chain reaction-sequence-specific primer. All data were...

The central Asian country Mongolia is home to more than 20 tribes and ethnic groups, some of which are related neighboring Turkic populations. main Mongolian people, Khalkha, live in eastern while the Tsaatan minority lives north country. Oold from western Altai mountain region close proximity with people. We have typed HLA-A, -B, -Cw, -DRB1 -DQB1 loci by PCR-SSP these three populations as well a sample German population. To examine their genetic relationships, Turkish population already at...

The number of patients with end stage renal disease (ESRD) is increasing faster than the transplantations performed per year worldwide. Of primary diseases leading to ESRD, diabetic nephropathy cause. purpose present study investigate association HLA ESRD in Turkish patients. A total 3230 individuals comprising 587 and 2643 healthy controls were enrolled into study. Class I HLA-A, -B typing was by CDC method, while class II HLA-DRB1 low resolution PCR-SSP. We found a significant negative...

Chronic myeloid leukemia (CML) occurs from childhood to old age. The adult form is characterized by the presence of Philadelphia chromosome resulting bcr/abl translocation. BCR-ABL fusion proteins are immunogenic, and junctional sequences show unique HLA class I II restriction patterns in vitro. A previous study west Scotland showed an influence several genotypes on age-at-onset CML. In present study, we examined HLA-A, -B, -DRB1/3/4/5 allele haplotype distributions Turkish CML patients...

Long-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, malignant tumor formation. Sister chromatid exchange (SCE) used assess the genotoxic potential various agents. total 37 postrenal transplant patients receiving either CsA (n = 20) or 17) were included in this study. The assessed by determination SCE frequency. In CsA, frequency was increased significantly compared that control group (p 0.001), whereas...

Abstract The ‘Immunogenetics of Aging’ is a newly included component within the 14th International HLA and Immunogenetics Workshop. aim this was to determine contribution human leukocyte antigen (HLA), cytokine genes other major histocompatibility complex‐encoded loci successful aging an increased capacity reach extreme limits life span. Two main data sets from four European populations were in study: unrelated healthy elderly individuals ethnically matched young controls, families with...

Patients with pre-transplantation high levels of panel reactive antibody (PRA) have an increased risk graft failure, and renal transplantation in sensitized patients remains a highly significant challenge worldwide. The influence anti-human leukocyte antigen (HLA) antibodies on the development rejection episodes depends patient-specific clinical factors differs from patient to patient. HLA typing recipient might anti-HLA antibodies. Some antigens appear be more immunogenic than others. aim...