A5042666128- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Oral and Maxillofacial Pathology
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Oral and gingival health research
- dental development and anomalies
- Genetic factors in colorectal cancer
- Childhood Cancer Survivors' Quality of Life
- Kruppel-like factors research
- Trace Elements in Health
- Chromosomal and Genetic Variations
- Hedgehog Signaling Pathway Studies
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- Nuclear Structure and Function
- Genetics and Neurodevelopmental Disorders
- Hematopoietic Stem Cell Transplantation
Istanbul University
2016-2025
Hacettepe University
2024
Sağlık Bilimleri Üniversitesi
2020
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2019
Medical Genetics Center
2002
Breast cancer (BC) is the most common among women with high morbidity and mortality. Therefore, new research still needed for biomarker detection. GSE101124 GSE182471 datasets were obtained from Gene Expression Omnibus (GEO) database to evaluate differentially expressed circular RNAs (circRNAs). The Cancer Genome Atlas (TCGA) Molecular Taxonomy of International Consortium (METABRIC) databases used identify significantly dysregulated microRNAs (miRNAs) genes considering Prediction Analysis...
Recent research suggests curcumin extracted from the turmeric plant may inhibit proliferation of cancer cells by controlling expression microRNAs (miRNAs). The effect phenolic on miR-638-5p and potential target gene expressions in triple negative breast (TNBC) cell line MDA-MB-231 was investigated this study.
Oligodontia is the agenesis of 6 or more teeth, excluding third molars. The etiology congenital absence teeth believed to be rooted in heredity developmental anomalies. patients can cause aesthetic, functional, and psychological problems, particularly if anterior region involved. This case report describes multidisciplinary treatment approach toward a patient 17 years age with non-syndromic oligodontia, 11 permanent teeth. Genetic counseling revealed non-syndromic, autosomal-recessive-linked...
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of target genes in cell. Breast cancer is responsible for majority cancer-related deaths among women globally. It has been proven deregulated miRNAs may play an essential role progression breast cancer. shown many cancers, including cancer, aberrant be associated with drug resistance. This study investigated effect let-7b-5p, detected by bioinformatics methods, on Dox resistance through Aurora Kinase B ( AURKB )...
Aims: Larynx squamous cell carcinoma (LSCC) is the second most common head and neck malignancy. While let-7b-3p has been shown to have a role in cancer progression malignancies, there no research examining association between LSCC let-7b-3p. This study aimed investigate expression status of potential roles this microRNA (miRNA) LSCC. Methods: Using quantitative real-time polymerase chain reaction (qRT-PCR), we examined let-7b3p 36 samples neighboring normal tissues. Then, miRNA mimic was...
Objective: Acute Myeloid Leukemia (AML) is distinguished by the differentiation and overgrowth of blast cells. In current study, we purposed to elucidate effect miR-7-5p on AML cellular processes expression level potential target genes. Methods: mimic was transfected into cells lipofectamine-mediated method verified qRT-PCR. The miR-7-5p's proliferation apoptosis investigated WST-8 Caspase-3 kit (respectively). miRDB, miRTarBase, Targetscan, miRWalk, https://ongene.bioinfo-minzhao.org/,...
The aim of this study was to investigate the genotoxic effect on peripheral blood lymphocytes potentially induced by yttrium-90 citrate colloid (Y-90) in children who were undergoing radiosynovectomy for hemophilic synovitis, using chromosomal aberration analysis (CA) and micronuclei (MN) assay detecting aberrations, as well sister chromatid exchanges (SCE) technique assessed DNA damage.Cytogenetic analyses undertaken 18 boys (mean age, 14.5 +/- 2.1 years) with synovitis underwent Y-90. CA,...
Abstract Autosomal recessive Robinow syndrome is caused by mutations in ROR2 and characterized short stature, mesomelic limb shortening, brachydactyly, vertebral abnormalities, a characteristic “fetal face” dysmorphology. We report the clinical molecular studies on two adults with this condition. Besides typical skeletal facial features, one patient developed hydronephrosis, nephrocalcinosis, renal failure. The second had manifestations including severe spinal involvement showed...
Abstract Objectives Multiple myeloma (MM) is a common hematological cancer. Hence, it important to conduct further studies investigating the molecular mechanisms in detail that contributes genesis. In addition genetic changes, epigenetic factors such as miRNAs may influence expression of myeloma-related genes. Methods Our study aimed detect genes closely related MM and involved cancer process by changing these with bioinformatics tools vitro methods. Bioinformatics approaches identified hub...
Analbuminemia is a rare autosomal recessive disorder in which individuals have little or no circulating albumin, usually the most abundant plasma protein. We describe new mutation associated with analbuminemia.We studied four apparently unrelated patients who had congenital analbuminemia: two of Amerindian and Turkish origin. The 14 exons flanking intron sequences albumin gene were amplified by PCR screened for mutations single-strand conformational polymorphism heteroduplex analysis....
The aim of this study was to investigate the genotoxic effect on peripheral blood lymphocytes potentially induced by Re-186 in paediatric age group undergoing radiosynovectomy for haemophilic synovitis, using chromosomal aberration analysis (CA) and micronuclei (MN) assay detecting aberrations, as well sister chromatid exchanges (SCE) technique assessing DNA damage.Cytogenetic analyses were evaluated 20 boys (mean age: 13.8 +/- 2.7 years) before, 2 90 days after from patients. Joint...
Anzer honey is well known in Turkey and used for its medicinal properties, especially pharyngitis, tonsillitis, ulcers cancer. In this study, we investigated whether honey, which shown to have antioxidant, anti-tumoral, anti-inflammatory has a protective effect against X-ray induced genotoxic damage by cytogenetic methods. Peripheral blood lymphocytes isolated from 20 healthy volunteers were divided into two groups cultivated conventional Study group treated with 10% diluted while those the...
Breast cancer (BC) is highly heterogeneous and one of the most common cancers. Luminal A (LUM A) a subtype BC with better prognosis than other subtypes. The molecular mechanisms underlying initiation progression LUM are still unclear. Big data generated from microarray sequencing systems can be re-analyzed, especially help various
Polymorphisms of the x-ray repair cross-complementing group 1 (XRCC1) gene have been reported to be associated with various forms cancer. We evaluated possible effects Arg194Trp and Arg399Gln polymorphisms on risk for chronic lymphocytic leukemia (CLL) in 73 patients 50 controls. also analyzed their relation frequency sister chromatid exchange (SCE). With respect codon 194, allelic polymorphism did not significantly differ between 2 groups. The proportion individuals carrying was different...
Purpose: Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures dentistry.The evaluation of the frequency sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess genotoxic effects environmental factors.Materials and Methods: In this study, various NSAIDs were assessed 30 patients who they administered following encluosed third molar surgery using SCE analysis before after operation.The was evaluated operation 3 days...