A5101497365- Cancer-related gene regulation
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cell Adhesion Molecules Research
- BRCA gene mutations in cancer
- Tumors and Oncological Cases
- Cancer-related Molecular Pathways
- Hearing, Cochlea, Tinnitus, Genetics
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Vestibular and auditory disorders
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Nasal Surgery and Airway Studies
- Obstructive Sleep Apnea Research
- Lung Cancer Treatments and Mutations
- Sinusitis and nasal conditions
Wakayama Medical University
2008-2023
keiyu Hospital
2021
Shinmatsudo Central General Hospital
2021
Istinye University
2019
Gelişim Üniversitesi
2019
Ministry of Health
2011-2019
İstanbul Eğitim ve Araştırma Hastanesi
2018
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2018
Istanbul University
2018
Sağlık Bilimleri Üniversitesi
2017
Degradation of basement membrane and extracellular matrix structures are important features the metastatic process malignant tumors. Human heparanase degrades heparan sulfate proteoglycans, which represent main components membranes matrix. Because role in tumor invasion metastasis, we examined expression primary gastric cancers cell lines derived from by immunohistochemistry RT-PCR, respectively. Four seven cancer showed mRNA RT-PCR. Heparanase protein was detected both cytoplasm nucleus...
The epidermal growth factor receptor (EGFR)–RAS–RAF–mitogen‐activated protein kinase signaling cascade is an important pathway in cancer development and recent reports show that EGFR its downstream molecules are mutated a number of cancers. We have analyzed 91 Japanese head neck squamous cell carcinomas (HNSCC) 12 HNSCC lines for mutations , ErbB2 K‐ras . Exons encoding the hot‐spot regions tyrosine domain both (exons 18, 19, 21) 18–23), as well exons 1 2 were amplified by polymerase chain...
Epithelial-mesenchymal-transition (EMT) is a critical step in tumor invasion and metastasis, while its fate mainly defined by the balanced expression between miR-200 family ZEB transcription factors. In this study, we observed reciprocal correlation miR-200c/mir-141 ZEB1, as well ZEB2 E-cadherin panel of 13 head neck squamous cell carcinoma (HNSCC) lines. We also confirmed that enforced miR-200c miR-141 significantly reduced migration capacity HNSCC cells. Accordingly, mir-141 resulted...
A novel therapeutic approach is urgently needed for patients with anaplastic thyroid cancer (ATC) due to its fatal and rapid progress. We recently reported that ATC highly expressed MYC protein blocking of through selective inhibitor, JQ1, decreased growth improved survival in preclinical models. One the important roles regulation L-neutral amino acid transporter 1 (LAT1) inhibition LAT1 would provide similar anti-tumor effect. first identified while human expresses protein, it little or not...
Idiopathic pulmonary fibrosis (IPF) is the most common and deadly form of interstitial lung disease. Osteopontin (OPN), a matricellular protein with proinflammatory profibrotic properties, plays major role in several fibrotic diseases, including IPF; OPN highly upregulated patients' samples. In this study, we knocked down bleomycin (BLM)-induced (PF) mouse model using small interfering RNA (siRNA) to determine whether use siRNA an effective therapeutic strategy for IPF. We found that...
Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with poor survival rate. Identifying the tumor suppressor gene (TSG) loci by genomic studies an important step to uncover molecular mechanisms involved in HNSCC pathogenesis. We therefore performed comprehensive analyses on loss of heterozygosity (LOH) using genome-wide panel 191 microsatellite markers 22 samples. found 53 significantly high LOH (>30%) 21 chromosomal arms; highest values those were observed 3p, 9p, 13q,...
Abstract Our previous study showed high frequency of allelic loss at chromosome 2q37 region in oral cancer. This location contains several candidate tumor suppressor genes such as PPP1R7, ILKAP , DTYMK and ING5 . We previously 3 members inhibitor growth ( ING ) family, ING1 ING3 ING4 gene head neck As shows homology with other including highly conserved carboxy‐terminal plant homeodomain nuclear localization signal, we first picked up examined it a possible For this aim, mutation mRNA...
Abstract Background. Although contribution of matrix metalloproteinases in cancer progression and dissemination is now well known, roles recently discovered metalloproteinases, a disintegrin metalloproteinase with thrombospondin motifs (ADAMTS), development remain mostly unknown. Methods. Here we examined the mRNA expression pattern 6 members ADAMTS aggrecanases (1, 4, 5, 8, 9, 15) primary head neck without metastasis by real‐time reverse transcriptase‐polymerase chain reaction. Results....
Although many clinical and pathological prognostic factors such as tumor stage lymph‐node involvement have been described, to date no reliable or clinically applicable marker aggressiveness has identified for head neck cancer. In an attempt identify a molecular marker, we analyzed the mRNA expression status of ING3 by quantitative reverse transcription–polymerase chain reaction. We also examined p53 mutation investigated its relationship with ING3, well clinicopathological characteristics....
Abstract Background Spindle cell carcinoma (SpCC) is a rare, high malignant variant of squamous (SCC), which shows biphasic proliferation conventional SCC component and spindle shape cells with sarcomatous appearance. Methods A case bone-like calcified materials, occurring at the mandibular molar region 71-years-old Japanese male patient was presented gross finding, histological findings MRI image. To identify characteristics immunohistochemistry were performed. Results Histologically,...
Background Genetic factors play a large role in cancer, and thus, there is great desire to understand the effects of different genes cancer also develop gene therapy for better treatments. Therefore, development alternative diagnosis modalities utmost importance. The aim our study was illuminate ESM 1 (endothelial cell‐specific molecule‐1, known as Endocan) proliferation migration head neck thus helping pave way new treatment predictive biomarkers. Methods expression shown with...
Focal adhesion kinase (FAK) is an important mediator functioning between cells and the extracellular matrix closely related with integrin-signaling pathway. FAK has been reported to be involved in proliferation, differentiation apoptosis of cells. To date, no report demonstrated involvement carcinogenesis digestive tract. Therefore, we examined colorectal, esophageal, pancreatic mammary cancers for expression Phospho (P)-FAK by immunohistochemistry. Strong cytoplasm was detected all 4 tumor...
Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are suppressors that physically and functionally interact with p53 perform important roles in apoptosis, DNA repair, cell cycle regulation, senescence. TP53 genetic alterations were reported...