A5019612804- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Glutathione Transferases and Polymorphisms
- Folate and B Vitamins Research
- Estrogen and related hormone effects
- Bee Products Chemical Analysis
- Diabetes and associated disorders
- Kidney Stones and Urolithiasis Treatments
- Genetics and Neurodevelopmental Disorders
- Metabolism, Diabetes, and Cancer
- Kawasaki Disease and Coronary Complications
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Kidney Injury Research
- Nutrition, Genetics, and Disease
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Cells and Metastasis
- Thyroid Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cardiovascular Disease and Adiposity
- Pharmacogenetics and Drug Metabolism
- Genomics, phytochemicals, and oxidative stress
- Mitochondrial Function and Pathology
Istanbul University
2014-2024
Czech Academy of Sciences, Institute of Experimental Medicine
2018
Adli Tıp Kurumu
2017
Hacettepe University
2014
Abstract The effects of 1,25‐dihydroxyvitamin D3 are mediated by binding to a specific intracellular vitamin D receptor (VDR), which has been identified in variety tissues. Certain polymorphisms the VDR gene have associated with various neoplasms. For this purpose, we studied whether TaqI or FokI genotype serum 25‐hydroxyvitamin 52 controls and 26 patients colorectal cancer. Polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP), agarose gel electrophoresis tecniques...
Researchers have started focusing on investigating the anticarcinogenic effects of natural products with slightest side possible, because current breast cancer treatment approaches are unable to achieve absolute success especially aggressive subtypes. Propolis is among these its antimicrobial, antifungal, anti-inflammatory, and anticancer effects. Therefore, seven different samples were collected from regions (Argentina, China, Istanbul-Turkey) applied nonaggressive cell line (BCCL) MCF-7...
In this study, eight different pomegranate (Punica granatum L.) cultivars from Turkey were evaluated for their antioxidant and cytotoxic effects on the MCF-7 breast cancer cell lines MCF-10A fibrocystic epithelial with a focus chemical compositions by LC-MS/MS. Cell treated juice extracts in doses at selected time intervals (24th, 48th, 72nd hour). Afterwards, WST-1 proliferation assay was performed to investigate cytotoxicity of extracts. Accordingly, all decreased viability had no effect...
Although meningioma is a common disease, there lack of understanding the underlying molecular mechanisms behind its initiation and progression. We used combined miRNA-mRNA transcriptome analysis to discover dysregulated genes networks in meningiomas. Fourteen fresh-frozen samples one human meningeal cell line were analyzed by using miRNA whole microarray chips. Data was filtered analyzed. Candidate miRNAs mRNAs selected for validation fifty-eight patient samples. target mRNA relationships...
Natural products with bioactive components are widely studied on various cancer cell lines for their possible cytotoxic effects, recently. Among these products, honey stands out as a valuable bee product containing many active phenolic compounds and flavonoids. Numerous types of multifloral honeydew produced in Turkey owing to its abundant vegetation. Therefore, this study, we investigated the effects particular tree-originated honeys from chestnut, cedar, pine, representing different most...
Maturity-onset diabetes of the young (MODY) is a highly heterogeneous group monogenic and nonautoimmune diseases. Misdiagnosis MODY widespread problem about 5% patients with type 2 mellitus nearly 10% 1 may actually have MODY. Using next-generation DNA sequencing (NGS) to facilitate accurate diagnosis MODY, this study investigated mutations in 13 genes (HNF4A, GCK, HNF1A, PDX1, HNF1B, NEUROD1, KLF11, CEL, PAX4, INS, BLK, ABCC8, KCNJ11). In addition, we comprehensively clinical phenotypic...
Abstract Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10‐methylenetetrahydrofolate to 5‐methyltetrahydrofolate, a carbon donor for the homocysteine methionine conversion. MTHFR keyenzyme regulates folate metabolism which has important role in DNA synthesis, repair and methylation. The association between C677T polymorphism breast cancer been investigated several previous studies. Some researchers have shown cancer, but not all found this however....
Although the functional consequences of MDR-1 polymorphisms have been subject numerous studies, to best our knowledge, associations with clinical side effects anticancer drugs yet be assessed. Our aim was clarify any role C3435T polymorphism MDR1 gene in oral mucositis and its relation elevated reactive oxygen species (ROS) levels, children acute lymphoblastic leukemia (ALL).The distribution 47 patients ALL determined by RFLP compared that 68 healthy controls.There were no association...
Diabetes is a common disorder with heterogeneous clinical presentation and an enormous burden on health care worldwide. About 1–6% of patients diabetes suffer from maturity-onset the young (MODY), most form monogenic autosomal dominant inheritance. MODY genetically clinically caused by genetic variations in pancreatic β-cell development insulin secretion. We report here new findings targeted next-generation sequencing (NGS) 13 MODY-related genes. A sample 22 unrelated pediatric healthy...
The aim of this study was to investigate the association between BRAF V600E mutation incidence and histopathologic prognostic risk factors for papillary thyroid carcinoma (PTC) on Turkish population. contribution in both tumor tumor-surrounding nontumoral tissues 108 patients with PTC assessed using mutant allele-specific amplification-polymerase chain reaction. found 52.8% tissues, 7.4% tissues. significantly higher classic variant (CVPTC) cases than follicular (p=0.001). presence more...
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The aim of this study was to determine the role polymorphic variants apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in development coronary heart disease (CHD), PPARD APOE gene-gene interaction a Turkish population. This carried out using sample 223 patients with CHD (103 diabetes 120 without diabetes) 101 controls. +294T/C genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism technique. genotype...