This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has possible restoring effect this sense. Fructose (30%; w/v) was administered to alone or together with RES (50 mg/L) drinking water for 8 weeks. In HFr group, destruction germinal epithelium led detection immature germ cells lumen. gave rise decrease ST diameters (p < 0.05), Johnsen's tubular biopsy score values 0.001), an increase apoptotic index...

Aortic aneurysm is a complex multifactorial disease, and its molecular mechanism not understood. In thoracic aortic (TAA), the expansion of wall lead by extracellular matrix (ECM) degeneration in medial layer, which leads to weakening wall. This dilatation may end rupture and—if untreated—death. The media composed vascular smooth muscle cells (VSMCs) proteins involved elasticity distensibility. Delineating their functional quantitative decrease critical elucidating disease causing mechanisms...

There is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan adhesion molecules such as P-selectin derived from endothelium platelets in obese children adolescents with NAFLD. One hundred patients 40 lean controls were enrolled. subjects divided into two subgroups based on presence or absence liver. Blood samples assayed endocan, P-selectin, platelet-derived growth factor...

ABSTRACT Plasma nitrotyrosine and nitrite/nitrate levels as markers of nitrosative stress plasma malondialdehyde (MDA) protein carbonyl oxidative were determined in patients with Behçet disease (BD). To evaluate the balance between oxidant antioxidant systems these patients, we measured erythrocyte lysate CuZn superoxide dismutase (CuZn SOD) activity, sulfhydryl (SH) values total activity. We also C‐reactive (CRP), a key marker inflammation, compared them those healthy subjects. found BD to...

A moderate increase in plasma total homocysteine (t-hcy) is considered to be an independent risk factor for cardiovascular disease (CVD) general population. One of the mechanisms by which hyperhomocysteinemia contributes has been explained increased thrombotic potential. Elevated t-hcy levels were also reported chronic renal failure patients because function a major determinant serum levels.We measured hcy and ADP-induced platelet aggregation tissue as activator coagulation cascade...

Abstract Introduction Crosstalk between bone and adipose tissues is implicated in several pathologic conditions related to metabolism. Omentin-1, a 34-kD protein, released from omental tissue. A few studies indicated the effect of omentin-1 on health mineral density (BMD) interaction with vitamin D. Therefore, this study aimed investigate relationship omentin-1, D, BMD postmenopausal women osteoporosis compared non-osteoporotic counterparts. Materials methods Forty (OP), 40 counterparts...

The immunosuppressive agent cyclosporine A (CsA) has hepatotoxic potential. Increased reactive oxygen species (ROS) formation is among the causes leading to hepatotoxicity. This study aimed investigate effect of resveratrol (RES) on CsA-induced oxidative stress and hepatotoxicity in rats. Rats were treated with RES (10 mg/kg/day; i.p.) for 14 days. CsA (25 s.c.) was given during last seven days together RES. Serum alanine aminotransferase aspartate activities hepatic histopathological...

Cyclosporine, an immunosuppressive drug, exhibits a toxic effect on renal and vascular systems. The present study investigated whether resveratrol treatment alleviates injury induced by cyclosporine. Cyclosporine (25 mg/kg per day, s.c.) was given for 7 days to rats either alone or in combination with (10 i.p.). Relaxation contraction responses of aorta were examined. Serum levels blood urea nitrogen, creatinine, angiotensin II, 1-7 measured. Histopathological examinations as well...

Cyclosporine A (CsA) is an immunosuppressive drug, used in organ transplantations. Oxidative stress, inflammation and renin-angiotensin system (RAS) activation play important role CsA-toxicity. Glycine (Gly) has antioxidant anti-inflammatory effects. In this study, Gly was investigated for its protective against CsA-induced toxicity. CsA (20 mg/kg/day; subcutaneously) administered to rats along with injection (250 or 1000 mg/kg; intraperitoneally) 21 days. Renal function markers [serum urea...

This study was designed to investigate the role of HO‐1 induction in prevention thioacetamide (TAA)‐induced oxidative stress, inflammation and liver damage. The changes hepatic dimethylarginine dimethylaminohydrolase (DDAH) activity as well plasma arginine asymmetric (ADMA) levels were also measured evaluate nitric oxide (NO) bioavailability. Rats divided into four groups control, hemin, TAA hemin + groups. Hemin (50 mg kg −1 , i.p.) injected rats 18 h before treatment induce enzyme...

Plasma levels of asymmetric dimethylarginine (ADMA) are known to be elevated under pathological conditions, but reports on intracellular ADMA scarce. In this study, we investigated whether lipopolysaccharide (LPS)-induced endotoxemia alters the intra- and extra-cellular partition l-arginine ADMA. The effect H 2 S pretreatment was also researched. Wistar rats were given sodium hydrogen sulfide (NaHS, 1 mg·(kg body mass) −1 ) one hour before LPS injections (20 mg·kg ). Six hours after...

Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is metabolized in the liver by dimethylaminohydrolase (DDAH). We aimed to investigate effect of rosiglitazone, a peroxysome proliferator-activated receptor-gamma (PPAR-γ) agonist, on ADMA metabolism acute injury. Male Sprague Dawley rats were injected thioacetamide (TAA; 500mgkg(-1)) intraperitoneally order induce ADMA, SDMA and arginine levels determined plasma HPLC. Liver DDAH activity malondialdehyde (MDA)...

High levels of fructose in the diet results metabolic abnormalities and vascular disorders. In this study, effect resveratrol (RES) on relaxation contraction responses was examined aorta high-fructose (HFr)-fed rats. mRNA expressions aortic sirtuin 1 (SIRT1), GLUT5, aldolase B were also investigated. Rats given (30%) (or) RES (50 mg · L(-1)) their drinking water for 8 weeks. HFr-fed rats, plasma arginine ratio arginine:asymmetric dimethylarginine (ADMA) decreased, whereas leptin increased....

Increased oxidative stress and disturbance in nitric oxide bioavailability lead to endothelial dysfunction cardiovascular complication renal disease. Gentamicin (GM), a commonly used antibiotic, exhibits toxic effect on proximal tubules. Prevention of its nephrotoxicity is important. Therefore, we investigated whether heme oxygenase 1 HO-1) induction influenced kidney vascular function GM-administered rats. GM (100 mg·kg-1·day-1; i.p.) was given rats alone or together with hemin (20 mg·kg-1...

Objective: Postmenopausal osteoporosis a disease with increased fracture tendency in the bones based upon reduced bone mineral density.Oxidative stress is an important risk factor for osteoporosis.In our study, it was aimed to investigate levels of oxidative markers women postmenopausal osteoporosis.Materials and Methods: In without also healthy controls; density, routine laboratory tests, 25-hydroxyvitamin D 3 , malondialdehyde, protein carbonyl total antioxidant capacity were...