A5053204801- Blood Coagulation and Thrombosis Mechanisms
- Adipose Tissue and Metabolism
- Blood properties and coagulation
- RNA modifications and cancer
- Venous Thromboembolism Diagnosis and Management
- Glutathione Transferases and Polymorphisms
- Diet and metabolism studies
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Blood Pressure and Hypertension Studies
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
- Cardiovascular Health and Disease Prevention
- Platelet Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
Istanbul University-Cerrahpaşa
2001-2025
Istanbul University
2008-2021
Npistanbul Brain Hospital
2017
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
2005
Vitamin D3 is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene located on chromosome 12q13 and consists of 9 exons. contains DNA-binding site encoded by exons 2 3 ligand-binding 4 - 9. Our earlier study showed ApaI polymorphic associated with late-onset Alzheimer's disease (AD). Here, we investigated association between additional polymorphisms AD using same samples. Two single nucleotide (SNPs) in intron 8 (BsmI Tru9I polymorphisms) one exon (FokI...
Background Alterations in biochemical and molecular pathways Alzheimer's disease (AD) may be evident the brain, blood cells, vessels. Platelets regulate hemostasis play key roles neurodegenerative diseases like AD. miR-26a-5p GP1b affect platelet functions (PF), with as a diagnostic/therapeutic target linking vascular neurological disorders AD progression. Objective This study explores of hsa-miR-26a-5p regulating PF Methods 85 participants, including 43 AD, 45 controls, were included....
Background The data that we gathered from a protein-protein interaction (PPI) prediction tool, FpClass, and limited number of studies indicated the chaperones HSP90AA1, HSPA4, STUB1/CHIP might interact with amyloid-β (Aβ) and/or tau could subsequently be co-released into cerebrospinal fluid (CSF). Therefore, investigated CSF levels in Alzheimer's disease (AD), Non-AD mild cognitive impairment (Non-AD MCI), frontotemporal dementia (FTD) cases. Methods STUB/CHIP, core AD biomarkers were...
Article Erythrocyte Glutathione, Glutathione Peroxidase, Superoxide Dismutase and Serum Lipid Peroxidation in Epileptic Children With Valproate Carbamazepine Monotherapy was published on March 1, 2000 the journal Journal of Basic Clinical Physiology Pharmacology (volume 11, issue 1).
The aim of this study was to measure changes in the antioxidant systems epileptic children who had been receiving either valproate or carbamazepine monotherapy for 2 years. For purpose, levels erythrocyte glutathione, glutathione peroxidase, superoxide dismutase, and serum lipid peroxidation 25 healthy 27 previously diagnosed as having epilepsy but not, prior study, received antiepileptic drugs were tested. Of children, 14 given valproate, remaining 13 carbamazepine; these tests repeated...
Platelets have the capacity to release mediators with potent inflammatory or anaphylactic properties. Platelet factor-4 (PF4) and beta-thromboglobulin (BTG) are two of these mediators. On other hand, plasminogen activator inhibitor-1 (PAI-1) tissue (tPA) important fibrinolysis. Both secreted mainly by vascular endothelium. Plasma levels PF4, BTG, PAI-1, tPA may show changes in chronic diseases such as asthma. This study examined role thrombocytes function endothelium ın asthmatic patients...
Inherited gene disorders related to the hemostatic system have been documented as risk factors for thrombosis. The roles of factor V Hong Kong (FV Kong), Leiden Leiden), II G20210A (FII G20210A), methylenetetrahydrofolate reductase (MTHFR) C677T, and MTHFR A1298C mutations in Turkish patients with thrombosis (270 patients) compared healthy controls (114 subjects) were evaluated. Polymerase chain reaction—based restriction enzyme analysis was carried out screen these mutations, single-strand...
Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most them are related with atherosclerotic coronary heart disease. Predictive value endothelial dysfunction markers earliest stage atherosclerosis has been getting more attention. We hypothesized that differences biochemical among genders would aid to capture proatherogenic activity was not diagnosed by conventional risk assessment scoring systems.We assessed dysfuntion 92 Turkish adults who were »low...
A moderate increase in plasma total homocysteine (t-hcy) is considered to be an independent risk factor for cardiovascular disease (CVD) general population. One of the mechanisms by which hyperhomocysteinemia contributes has been explained increased thrombotic potential. Elevated t-hcy levels were also reported chronic renal failure patients because function a major determinant serum levels.We measured hcy and ADP-induced platelet aggregation tissue as activator coagulation cascade...
Purpose: Glioblastoma (GBM) is the most aggressive primary brain tumour in adult nervous system and associated with a poor prognosis. NF-KB activation an important driver of malignant phenotype that confers negative prognosis patients GBM. plays role Toll-like Receptors (TLR)-induced tumourigenesis. The aim present study was to investigate association promoter region polymorphism NFKB1 gene encoding p50 subunit NF-KB, namely -94ins/del ATTG, widely discussed TLR2 Arg753Gln, TLR4Asp299Gly...
Several inherited polymorphisms are associated with risk of venous thrombosis, including mutation at codon 506 the factor V gene, position 20210 prothrombin and mutations in protein C gene. In this study, genotyping for V, prothrombin, was performed 50 patients 25 control subjects by polymerase chain reaction—based analysis. The prevalence not significantly different from that general population. Nine had heterozygous mutation. There a high mutated allele pulmonary emboli group (42.8%)....
Mitochondrial dysfunctions are significant contributors to neurodegeneration. One result or a cause of mitochondrial dysfunction might be the disruption mtDNA transcription. Limited data indicated an altered expression encoded transcripts in Alzheimer's disease (AD) Parkinson's disea se (PD). The number mitochondria is high cells with energy demand, such as muscle nerve cells. AD PD involves increased risk cardiomyopathy, suggesting that systemic. If it systemic, we should observe different...
Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer of head and neck. In order to identify differentially expressed genes which may have a role in LSCC carcinogenesis, we performed GeneFishing Assay. One was SLC22A23 (solute carrier family 22, member 23) gene. belongs organic ion transporters that are responsible for absorption or excretion many drugs, xenobiotics endogenous compounds variety tissues. various tissues but no substrates functions been identified it....
Abstract Although there are extensive studies on the genetics of bladder cancer, several questions remain unanswered. One pathways which altered in cancer is mTOR signaling pathway. In present study, we analyzed expression Rheb gene and genetic alterations LKB1 key components Nine exons were by direct sequencing 51 patients. To investigate LKB1, real‐time quantitative RT‐PCR was performed tumor normal tissue samples. We did not observed a statistically significant difference or between...