A5053982035- Antiplatelet Therapy and Cardiovascular Diseases
- Tuberculosis Research and Epidemiology
- Alzheimer's disease research and treatments
- Mycobacterium research and diagnosis
- History and Cultural Heritage
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Asthma and respiratory diseases
- Systemic Sclerosis and Related Diseases
- Inflammatory mediators and NSAID effects
- Peripheral Artery Disease Management
- Inflammatory Biomarkers in Disease Prognosis
- Metallurgy and Cultural Artifacts
- Cardiovascular Disease and Adiposity
- Sports Performance and Training
- MicroRNA in disease regulation
- Parasitic Infections and Diagnostics
- Physical Education and Training Studies
- Pregnancy and preeclampsia studies
- Cerebrovascular and genetic disorders
- Ancient Near East History
- Molecular Biology Techniques and Applications
- Kruppel-like factors research
Namık Kemal University
2023-2025
Istanbul University-Cerrahpaşa
2016-2023
Npistanbul Brain Hospital
2017
Istanbul University
2012-2017
Background Alterations in biochemical and molecular pathways Alzheimer's disease (AD) may be evident the brain, blood cells, vessels. Platelets regulate hemostasis play key roles neurodegenerative diseases like AD. miR-26a-5p GP1b affect platelet functions (PF), with as a diagnostic/therapeutic target linking vascular neurological disorders AD progression. Objective This study explores of hsa-miR-26a-5p regulating PF Methods 85 participants, including 43 AD, 45 controls, were included....
Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most them are related with atherosclerotic coronary heart disease. Predictive value endothelial dysfunction markers earliest stage atherosclerosis has been getting more attention. We hypothesized that differences biochemical among genders would aid to capture proatherogenic activity was not diagnosed by conventional risk assessment scoring systems.We assessed dysfuntion 92 Turkish adults who were »low...
Several nucleic acid amplification techniques (IS6110, 16S rRNA, and 85B mRNA) were developed for the rapid, direct detection of Mycobacterium tuberculosis. We aimed to assess diagnostic performance mRNA-based RT-qPCR by comparing with real-time PCR COBAS TaqMan MTB Kit while using BACTEC MGIT 960 method as gold standard.60 patients confirmed pulmonary TB 60 individuals without included study control groups, respectively. Sputum specimens cultured LJ systems. Extracted DNA was used in a...
Metabolic syndrome (MetS) is one of the high cardiovascular (CV) situations. Endothelial dysfunction, which a common finding in patients with MetS, related increased CV risk. In effect major risk factors, not included MetS definition, on endothelial dysfunction well known. The aim this study was to determine factors such as gender, smoking, family history, and biochemical parameters MetS.The performed between December 2010 August 2014. A total 55 (15 females 40 males) 81 healthy controls (37...
Background: Recently, it has been showed that obesity strongly increase risk of morbidity and mortality caused by cardiovascular complications including atherosclerosis, disorders (CD), coronary heart disease. Obesity which developes due to multifactorial reasons, was associated with human Adenovirus-36(Ad-36). In this study, we aimed investigate the role adenovirus 36 induced in CD. Methods & Materials: cross-sectional case-control based 75 obese(BMI ≥ 30 kg/m2) adults problems, 28...
Objective: Platelets are 4-7 Micron diameter blood cells that play an important role in coagulation and inflammation with the substances they secrete membrane proteins. Although there many studies investigating effect of a magnetic field on living organisms cells, it’s mechanism has not been clarified yet. It demonstrated low-intensity activates leukocytes increases their number, but controversial data regarding its platelets. In this study, we aimed to examine effects platelet functions....
Amaç: Koroner Arter Hastalığı (KAH), çoğunlukla ateroskleroz sebebiyle kalbi besleyen damarların daralması veya tıkanması ile ortaya çıkmaktadır. Ateroskleroz patogenezinde aterosklerotik risk faktörlerinin yanı sıra inflamasyon, endotel disfonksiyonu ve buna bağlı olarak trombosit aktivasyonu sıklıkla görülmektedir. KAH’da fonksiyonlarını araştıran çalışmalar olmasına rağmen, hastalık şiddeti arasındaki ilişkiye dair kısıtlıdır. Bu çalışmada, tıkalı damar sayısı fonksiyonları ilişkiyi...
Background: It was reported that there is an inverse relationship between the presence of H.pylori and asthma Th2 response may be directed to Th1 in asthmatic persons by HP-NAP A. We reporte quantity gut microbiota children with allergic comparing healthy controls. Additionnaly we report gene expression levels Methods & Materials: From March 2014 January 2015 bacterial DNA RNA were isolated from stool samples 92 aged 3 8 years 88 age, gender matched The determined Real Time PCR cDNA...
Background: Dientamoeba fragilis is a neglected intestinal protist associated with clinical outcomes in humans. There still an obscurity about its pathogenicity humans, including whether it can modulate immune responses, through which mechanisms initiates infection, or mostly silent resident of human gut. are many studies and case reports all indicate D. as the causative agent patients diarhhea, abdominal pain, meteorism urticaria. Yet, may have pathogenic subtypes and/or act pathogen under...
Background: The problems with any PCR method using DNA sequences as targets for amplification include false-positive results, the inability to detect a difference between viable and nonviable organisms determine drug susceptibility. Instead of detecting assays, RT-qPCR assess expression 85B mRNA gene M. tuberculosis indicates presence organism. In this study, we used coding antigen complex which is present in all mycobacteria. We aimed diagnostic performance by comparing real-time Cobas...
Abstract Background Alzheimer's Disease (AD) is a progressive complex neurodegenerative disorder clinical characterized by demolishing cognitive functions and behavioral abilities. Until recently, molecular mechanisms of AD have not been clarified yet. Alterations in biochemical pathways patients suffering from may only emerge the brain but also could affect blood cells vessels. Platelets are that crucial function regulation hemostasis play an important role pathophysiological conditions...
Abstract Objective: Our primary aim was to investigate the relationship between biomarkers of endothelial dysfunction (ED) using analyzing intercellular adhesion molecule-1 (ICAM-1), plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), interleukin-6 (IL-6), C-reactive protein (CRP) and specific clinical findings cerebral small vessel disease (SVD), such as presence minor stroke or cognitive impairment. We also performed a correlation analysis ED neuroimaging markers...