A5052794936- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diet, Metabolism, and Disease
- Cardiac Imaging and Diagnostics
- Natural Products and Biological Research
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Cardiac and Coronary Surgery Techniques
- Nitric Oxide and Endothelin Effects
- Endoplasmic Reticulum Stress and Disease
- Plant biochemistry and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Protein Kinase Regulation and GTPase Signaling
- Liver Disease Diagnosis and Treatment
- Botanical Studies and Applications
- Neurological Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
- Reproductive Health and Contraception
- Diagnosis and Treatment of Venous Diseases
Istanbul University
2012-2025
Arterial and venous graft spasm can occur during harvesting or immediately after coronary artery bypass grafting (CABG), leading to increased perioperative morbidity affecting patency rates. Bypass grafts harvested from diabetic patients are particularly prone spasm. This study aimed elucidate the functional characteristics of human for internal mammary (IMA) saphenous vein (SV), both non-diabetic patients, determine how diabetes affected their responses spasmogenic relaxant agents. SV IMA...
Perivascular adipose tissue (PVAT) plays a crucial role in vascular homeostasis. Recent studies demonstrated that endoplasmic reticulum (ER) stress and autophagy are activated Type 2 diabetes mellitus (T2DM), while the precise of ER PVAT is unclear. We aimed to investigate possible influence pioglitazone on response T2DM rats. was induced by high‐fat diet/low‐dose streptozotocin (HFD/STZ) male Wistar rats (8–10 weeks), (20 mg/kg/p.o.) administered for 6 weeks. Changes biochemical parameters...
Drug-eluting stents, which release antiproliferative agents such as sirolimus and everolimus, were developed to reduce the risk of restenosis associated with bare-metal stents. However, despite their proven clinical efficacy, concerns remain regarding in-stent due delayed endothelial healing late thrombotic events. In this study, we aimed determine vascular effects everolimus on isolated human saphenous vein (SV) samples obtained from patients undergoing coronary artery bypass surgery. SV...
Vascular dysfunction plays a key role in the pathogenesis of diabetic vascular disease. In this study, we aimed to investigate whether chronic vivo treatment Crataegus microphylla ( CM ) extract rats induced with streptozotocin (STZ, intraperitoneal, 65 mg/kg) preserves function and evaluate reduction inducible nitric oxide synthase (iNOS), proinflammatory cytokines, lipid peroxidation mediates its mechanisms action. Starting at 4 weeks diabetes, (100 was administrated for weeks. aortic...
Perivascular adipose tissue (PVAT) plays an important role in many physiological and pathological processes, such as regulation of vascular tone. The aim this study is to evaluate the effects pioglitazone on functional, structural, biochemical properties PVAT experimental model type-2 diabetes (T2DM). T2DM was induced by high-fat-diet/low-dose-streptozotocin (HFD/STZ) rats, (20mg/kg/p.o.) administered for 6 weeks. Changes parameters, PVAT-mass, vascular-reactivity thoracic-aorta well...
Statins are known to display benefits in various diseases independently from their cholesterol lowering properties. In this study, we investigated the acute effects of atorvastatin on vascular reactivity spasmogens isolated rat aorta. The responses noradrenaline (NA, 10(-8) -10(-4) m), endothelin-1 (ET-1, 10(-10) -10(-7) and potassium chloride (KCl, 10-100 mm) were evaluated aortic rings pretreated with (10(-7) m, 30 min). To verify mechanism action, studied presence precursor, mevalonate...
High levels of fructose in the diet results metabolic abnormalities and vascular disorders. In this study, effect resveratrol (RES) on relaxation contraction responses was examined aorta high-fructose (HFr)-fed rats. mRNA expressions aortic sirtuin 1 (SIRT1), GLUT5, aldolase B were also investigated. Rats given (30%) (or) RES (50 mg · L(-1)) their drinking water for 8 weeks. HFr-fed rats, plasma arginine ratio arginine:asymmetric dimethylarginine (ADMA) decreased, whereas leptin increased....
Alzheimer Disease (AD) characterized by the progressive cognitive and functional impairment, is most common form of dementia affecting people worldwide. In this study, we aimed to investigate profile patients with AD, perception caregivers about disease role pharmacist in pharmacotherapy AD implementing a questionnaire for 44 AD. 70% evaluated female gender 52% cases, hypertension co-exists The combination memantine/donepezil (34%) was found commonly used pharmacological treatment which...
The use of inhaler device (UID) and the satisfaction adherence patients to treatment were evaluated by Istanbul city community pharmacists obtain real-life data from with asthma or chronic obstructive pulmonary disease (COPD).Pharmacists educated specialists asked who combined medications devices fill out a questionnaire prepared specialists. Each patient's UID was checked, their errors corrected showing them already standard video device. Afterward, repeated rechecked. visual analog scale...
Objective: Rosuvastatin displays favorable pleiotropic effects on vascular system to reduce the risk of cardiovascular events besides providing an intensive reduction in LDL-C levels. The role perivascular adipose tissue (PVAT) modulating vasorelaxant effect rosuvastatin is not evaluated so far. present study aimed investigate relaxant rat aortic rings with intact PVAT, as well evaluate possible mechanisms underlying this relation nitric oxide (NO) and prostaglandin pathways. Methods:...
Background and Aims: Inhaled drug-delivery is the cornerstone for treatment of asthma chronic obstructive pulmonary disease (COPD). However, these diseases cannot be adequately controlled in most patients due to misuse inhaler devices poor patient compliance. Patient education a critical component requires cooperative effort physicians pharmacists. This study aimed evaluate pharmacists’ ability use their practical knowledge, assess extent which pharmacists have consulted on this issue...