Abstract Solid lipid nanoparticles (SLN), nanostructured carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment painful inflammatory conditions skin. Compritol® 888 ATO, Lanette® O oleic acid used as solid liquid lipids. SLN, NLC NE found physically stable at various temperatures 6 months. Case I diffusional drug release was detected dominant mechanism indicating Fickian diffusion from nanoemulsion. The highest rate penetration through rat skin obtained with...

Perivascular adipose tissue (PVAT) plays a crucial role in vascular homeostasis. Recent studies demonstrated that endoplasmic reticulum (ER) stress and autophagy are activated Type 2 diabetes mellitus (T2DM), while the precise of ER PVAT is unclear. We aimed to investigate possible influence pioglitazone on response T2DM rats. was induced by high‐fat diet/low‐dose streptozotocin (HFD/STZ) male Wistar rats (8–10 weeks), (20 mg/kg/p.o.) administered for 6 weeks. Changes biochemical parameters...

Acetamiprid (ACE), a commonly used neonicotinoid insecticide, is correlated with neurological symptoms, immunotoxicity and hepatotoxicity. Cellular stress damage could play an important role in ACE-induced neurotoxicity; however, its mechanism has not been fully understood. We evaluated the effects of ACE on oxidative stress, endoplasmic reticulum (ER) cellular death, mRNA expression levels related genes protein expressions molecular mechanisms SH-SY5Y human neuroblastoma cells. The half...

Citrinin (CIT) is a mycotoxin produced as secondary product by the genera Aspergillus, Penicillium, Monascus, and other strains. CIT has potential for contaminating animal feed human food such maize, wheat, rye, barley, oats, rice, cheese, sake. Although primarily known nephrotoxic mycotoxin, it also affects organs, including liver bone marrow, its mechanisms of toxicity have not been clearly elucidated. There further lack studies investigating CIT-induced neurotoxicity mechanisms. In...

Colorectal cancer is the third most common cause of cancer-related mortality. Previous studies demonstrated increased telomerase activity in colorectal tissue and suggested a prognostic value for patients with carcinoma. Telomerase reverse transcriptase (TERT), one main functional subunits telomerase, an important factor modulating activity, telomere length, genomic stability. However, there are few that have addressed association between genetic variation at TERT risk cancer.We evaluated...

Glyphosate (N-phosphonomethyl glycine) is a non-selective, organophosphate herbicide widely used in agriculture and forestry. We investigated the possible toxic effects of glyphosate active compound its commercial formulation (Roundup Star ® ) human hepatocellular carcinoma (HepG2) cell line, including their on cytotoxicity, proliferation, reactive oxygen species (ROS) levels, expression oxidative stress-related genes such as HO-1, Hsp70 Nrf2, L-FABP, Keap1. MTT NRU tests indicated that IC...

Lipid nanoparticles have been paid growing interest for topical application of non-steroidal anti-inflammatory drugs to increase skin penetration and reduce side effects. Solid lipid nanostructured carriers celecoxib were prepared by high-pressure homogenization technique. Transmission electron microscopy, fourier transform infrared spectroscopy, differential scanning calorimetry, photon correlation spectroscopy laser diffraction used characterization nanoparticles. Their physical stability...

Abstract Fumonisin B 1 (FB ), which is emerged by contamination of corn and similar products with Fusarium species, causes a high risk for human animal health. FB shows hepatotoxic, nephrotoxic, neurotoxic, immunotoxic teratogenic effects. has also been linked to carcinogenesis processes that are unrelated genotoxic pathways. Our goal was investigate the role gene-specific DNA methylation expression tumour suppressor genes in toxicity kidney (HK-2) cells. Using array panels, effects exposure...

Perivascular adipose tissue (PVAT) plays an important role in many physiological and pathological processes, such as regulation of vascular tone. The aim this study is to evaluate the effects pioglitazone on functional, structural, biochemical properties PVAT experimental model type-2 diabetes (T2DM). T2DM was induced by high-fat-diet/low-dose-streptozotocin (HFD/STZ) rats, (20mg/kg/p.o.) administered for 6 weeks. Changes parameters, PVAT-mass, vascular-reactivity thoracic-aorta well...

Valerenic acid (VA) is a sesquiterpenoid and phytoconstituent of the plant valerian used for sleeping disorders anxiety. The frequency using herbal components as therapeutic nutritional agents has increased lately. Their ability to improve redox homeostasis makes them valuable approach against harmful xenobiotics. purpose this study was evaluate putative beneficial role VA redox-perturbating fungicide benomyl in HepG2 human liver cells terms oxidative stress cellular environment endoplasmic...

Zearalenone is a mycotoxin widely found worldwide that produced by several fungal species. Due to its similarity estradiol, it has been shown have toxic effects on the reproductive system. Although various animal studies conducted investigate of zearalenone, mechanisms toxicity not fully elucidated. The aim study was dose-dependent zearalenone exposure in human kidney cells. half-maximal inhibitory concentration values HK-2 cells were be 133.42 and 101.74 µM MTT- NRU-tests, respectively. at...

<title>Abstract</title> Ulcerative colitis is an inflammatory bowel disease characterized by inflammation and increased oxidative stress in the colon tissue. Sodium phenylbutyrate (PBA) suramin are histone deacetylase inhibitors that alter gene expression keeping histones acetylated form. Our aim this study was to determine effects of PBA on tissue acute model mice clarify mechanisms their action. induced 3% dextran sulfate sodium (DSS). After injection, activity index (DAI) scoring were...

Amaç: Günümüzde en çok çalışılan Fusarium mikotoksin türleri arasında fumonisin B1 (FB1) ve zearalenon (ZEA) bulunmaktadır. FB1 ZEA farklı moleküler mekanizmaları etkilemekte olup birçok toksik etkiye sebep olmaktadır. Bu derlemede ZEA’nın DNA metilasyonu, histon modifikasyonları mikroRNA (miRNA) seviyeleri gibi epigenetik mekanizmalar üzerine etkileri düzeyde gözlenen etkilerinin özetlenmesi amaçlanmıştır. Sonuç Tartışma: metilasyonunu, modifikasyonunu miRNA seviyelerini uygulama süresi...