A5075236751- Pesticide Exposure and Toxicity
- Pharmacogenetics and Drug Metabolism
- Pesticide and Herbicide Environmental Studies
- Carcinogens and Genotoxicity Assessment
- Insect and Pesticide Research
- Medicinal Plant Extracts Effects
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Colorectal Cancer Treatments and Studies
- Redox biology and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Telomeres, Telomerase, and Senescence
- Sperm and Testicular Function
- Insect Pest Control Strategies
- biodegradable polymer synthesis and properties
- Heme Oxygenase-1 and Carbon Monoxide
- Ovarian function and disorders
- Tryptophan and brain disorders
- Drug Transport and Resistance Mechanisms
- Vitamin C and Antioxidants Research
- Per- and polyfluoroalkyl substances research
- Nanoparticles: synthesis and applications
- Paraoxonase enzyme and polymorphisms
- Metabolomics and Mass Spectrometry Studies
- Polymer Science and PVC
Istanbul University
2015-2024
Fungicides are used in the agricultural sector against harmful action of fungi, however they potential toxic agents for environment and living organisms. Benomyl is a widely encountered benzimidazole fungicide that exerts its toxicity via inhibiting microtubule formation nervous system male reproductive endocrine systems, whilst it known teratogen. Since effects benomyl molecular mechanisms not fully understood, we aimed to detect neurotoxic evaluating cytotoxicity, oxidative stress...
Abstract Inappropriate disposal of plastic wastes and their durability in nature cause uncontrolled accumulation land/marine ecosystems, also causing destructive effects by bioaccumulating along the food chain. Microplastics may chronic inflammation relation to permanent structures, especially through oxidative stress cytotoxic cellular damage, which could increase risk cancer development. The microplastics liver is a major concern, therefore, identification mechanisms hepatotoxic great...
Background: Melissa officinalis L. (MO), commonly known as lemon balm, a member of the mint family, is considered calming herb. In various traditional medicines, it has been utilized to reduce stress and anxiety promote sleep. A growing body clinical evidence suggests that MO leaf extract supplementation possesses considerable neuropharmacological properties. However, its possible mechanism action largely remains unknown. Objective: present in vitro studies, we comparatively investigated...
Abstract Objectives To determine of antioxidant, cytotoxic and tyrosinase inhibitory (TI) activities, phenolic profiles with a new high performance liquid chromatography (HPLC) method green, white black teas. Methods Antioxidant activities the teas were examined by means scavenging free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), cupric capacity (CUPRAC). The contents investigated HPLC. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...
Acetamiprid (ACE), a commonly used neonicotinoid insecticide, is correlated with neurological symptoms, immunotoxicity and hepatotoxicity. Cellular stress damage could play an important role in ACE-induced neurotoxicity; however, its mechanism has not been fully understood. We evaluated the effects of ACE on oxidative stress, endoplasmic reticulum (ER) cellular death, mRNA expression levels related genes protein expressions molecular mechanisms SH-SY5Y human neuroblastoma cells. The half...
Zoledronic acid, a nitrogen-containing bisphosphonate drug, is used for the treatment of osteoporosis, Paget's disease bone, and tumor-induced osteolysis. acid has also gained place in cancer due to its cytotoxic antiproliferative effects many cells. Although zoledronic considered safe, kidney damage still one concerns therapeutic doses. In study, aim was assess nephrotoxic profiles human embryonic (HEK-293) Cytotoxicity evaluation performed by...
Despite a reduction in the number of deaths from cancers made possible by development early detection tests, improvements treatment, changes age distribution population, and personal behaviors as result awareness, breast cancer remains major health problem worldwide. Breast is most common second leading cause death women. Several genetic environmental factors are known to be involved pathogenesis, but its exact etiology complicated not clearly identified. The structure integrity telomeres...
Neonicotinoid insecticides, 30% of insecticides marketed worldwide, have selective toxicity on insects through α4p2 nicotinic acetylcholine receptors. Although it is known that acetamiprid exerts several organ systems, its toxic effects the pancreas and mechanism action not been clarified yet. Therefore, in present study, cytotoxic genotoxic potentials AR42J pancreatic cell line were evaluated.The (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) (MTT) assay comet conducted for...
Colorectal cancer is the third most common cause of cancer-related mortality. Previous studies demonstrated increased telomerase activity in colorectal tissue and suggested a prognostic value for patients with carcinoma. Telomerase reverse transcriptase (TERT), one main functional subunits telomerase, an important factor modulating activity, telomere length, genomic stability. However, there are few that have addressed association between genetic variation at TERT risk cancer.We evaluated...
Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, physiological function. Hypothyroidism is common endocrine disorder, which generally results from diminished normal circulating concentrations serum thyroxine (fT4) triiodothyronine (fT3). The primary choice hypothyroidism treatment oral administration levothyroxine (L-T4), synthetic T4 hormone, as approximately 100–125 μg/day. Generally, dose adjustment made by trial error...
Grape seed extract (GSE) from Vitis vinifera L. is rich in polyphenols and oligomeric proanthocyanidin complexes (OPCs), it has shown potential benefits managing low mood cognitive function. In this study, we investigated the bioactivities of Enovita®, a standardized GSE (GSEe herein) OPCs, key mechanistic pathways related to conditions vitro assays were conducted assess GSEe's inhibitory effects on γ-aminobutyric acid transaminase (GABA-T) monoamine oxidase A (MAO-A), its binding affinity...
Type 2 diabetes (T2DM) is one of the most serious challenges 21th century with life-threatening complications and excessive health care costs. In diabetic patients, main goal in T2DM treatment regulation both blood glucose lipid levels. For that, Gliclazide (GLZ), an oral antidiabetic, Atorvastatin (ATV), a lowering agent, are widely used drugs as combination. Diabetes has been reported severe impacts on male reproductive system; however, data obtained about ATV GLZ alone or combination...
Perfluorooctanoic acid (PFOA) is used in different industrial and commercial products. Research shows the presence of PFOA home dusts, tap surface water, biological samples. The International Agency for on Cancer (IARC) has classified as a possible carcinogen humans. liver thought to be target organ accumulation toxicity.Some studies have found toxic effects related mechanisms; however, more are needed better understand - induced hepatotoxicity.In present study, human hepatocarcinoma cell...
Valerenic acid (VA) is a sesquiterpenoid and phytoconstituent of the plant valerian used for sleeping disorders anxiety. The frequency using herbal components as therapeutic nutritional agents has increased lately. Their ability to improve redox homeostasis makes them valuable approach against harmful xenobiotics. purpose this study was evaluate putative beneficial role VA redox-perturbating fungicide benomyl in HepG2 human liver cells terms oxidative stress cellular environment endoplasmic...
Prochloraz is a broad-spectrum contact imidazol fungicide used against several diseases in wheat, barley and oleaginous plants but also for treatment of flower production. Although prochloraz has endocrine disrupting hepatocarcinogenic effects, there lack data on toxic effects prochloraz. Therefore, we aimed to investigate the DNA damage NRK-52E cells by using Ames Comet assay. By standard alkaline assay procedure, was no observed after 24 h exposure. It showed that caused neither base-pair...
Aim: Colorectal cancer (CRC) is a major health problem despite recent improvements in overall survival rates. Genetic polymorphisms affecting carcinogen biotransformation or DNA repair play pivotal roles the carcinogenesis process. CYP1A1*2A (6235 T/C, rs4646903, MspI) thought to be associated with an increased risk of CRC because its role metabolic activation polycyclic aromatic hydrocarbons; however, results previous studies are conflicting. In this study, possible association between...
Bismuth (III) oxide nanoparticles' (Bi2 O3 -NPs) unique physicochemical properties have attracted attention in biological, industrial, technological and medical fields. Concurrently, increasing numbers of studies revealing their potential toxic effects possible toxicity mechanisms are ongoing. In this study, we assessed the potentials Bi2 -NPs human SH-SY5Y neuroblastoma cell line. After characterization using TEM, cytotoxic were evaluated by MTT LDH assays. The induction reactive oxygen...
Pyrethroids, including allethrin, bioallethrin, deltamethrin, and esbiothrin, are widely used to control a broad range of pests in agriculture, public health, households as alternative organophosphorus organochlorine insecticides. Even if the pyrethroids known lead asthma; allergic dermatitis; respiratory diseases; immunosuppressive, reproductive, carcionogenic effects with long-term exposure, data on their cancer risk still conflicting. Moreover, exposure pesticides synthetic is highly...