A5068985110- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Metabolomics and Mass Spectrometry Studies
- Genetics and Physical Performance
- Mass Spectrometry Techniques and Applications
- High Altitude and Hypoxia
- Prostate Cancer Treatment and Research
- Biosensors and Analytical Detection
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Silymarin and Mushroom Poisoning
- Advanced Proteomics Techniques and Applications
- Cell death mechanisms and regulation
- Flood Risk Assessment and Management
- Muscle metabolism and nutrition
- Metal-Catalyzed Oxygenation Mechanisms
- Nigella sativa pharmacological applications
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Urban Stormwater Management Solutions
- Vitamin D Research Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
University of Oxford
2015-2025
Liaquat University of Medical & Health Sciences
2022-2024
China Medical University
2017-2024
Korea University of Science and Technology
2022-2024
Korea Institute of Civil Engineering and Building Technology
2022-2024
Massachusetts General Hospital
2016-2023
Harvard University
2016-2023
University of Peshawar
2023
John Radcliffe Hospital
2022-2023
Universal Scientific Education and Research Network
2023
Background: Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and vivo studies to be possible anti-COVID-19 candidate. Quercetin strong antioxidant, anti-inflammatory, immunomodulatory, antiviral properties, it is characterized very high safety profile, exerted animals humans. Like most other polyphenols, quercetin shows low rate of oral absorption its clinical use considered modest utility. delivery-food grade system with...
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of ongoing global pandemic known as COVID-19. Based on potential antiviral role quercetin, and its described anti-blood clotting, anti-inflammatory antioxidant properties, we hypothesize that subjects with mild COVID-19 treated Quercetin Phytosome ® (QP), a novel bioavailable form may have shorter time to virus clearance, milder symptomatology, higher probabilities benign earlier resolution disease....
Metabolomic profiling of prostate cancer (PCa) progression identified markedly elevated levels sarcosine (N-methyl glycine) in metastatic PCa and modest but significant elevation the metabolite urine. Here, we examine role key enzymes associated with metabolism progression. Consistent our earlier report, were significantly urine sediments compared to controls, a area under receiver operating characteristic curve 0.71. In addition, expression biosynthetic enzyme, glycine N-methyltransferase...
Background: Curcumin, quercetin, and vitamin D3 (cholecalciferol) are common natural ingredients of human nutrition reportedly exhibit promising anti-inflammatory, immunomodulatory, broad-spectrum antiviral, antioxidant activities. Objective: The present study aimed to investigate the possible therapeutic benefits a single oral formulation containing supplements curcumin, cholecalciferol (combinedly referred here as CQC) an adjuvant therapy for early-stage symptomatic coronavirus disease...
Background: Quercetin, a natural polyphenol with demonstrated broad-spectrum antiviral, anti-inflammatory, and antioxidant properties, has been proposed as an adjuvant for early-stage coronavirus disease 2019 (COVID-19) infection. Objective: To explore the possible therapeutic effect of quercetin in outpatients mild to moderate symptoms COVID-19. Methods: This was open-label randomized controlled clinical trial conducted at department medicine, King Edward Medical University, Lahore, PK....
Hyperuricemia is associated with several metabolic and cardiovascular disorders, traditional treatments, such as xanthine oxidase (XO) inhibitors, often have limitations, severe hypersensitivity reactions or ineffectiveness in achieving target serum urate levels some patients. Quercetin, a naturally occurring flavonoid, has shown potential hypouricemic agent through XO inhibition. This study aims to evaluate the effect of Quercetin Phytosome™ (QP) supplementation across three cohort studies...
The American Cancer Society estimates that in 2006, 212,920 women will be diagnosed with breast cancer and 40,970 die from the disease. development of more efficacious chemotherapies has improved outcomes, but rapid assessment clinical benefit these agents remains challenging. In patients receiving neoadjuvant chemotherapy, treatment response is traditionally assessed by physical examination volumetric-based measurements, which are subjective require macroscopic changes tumor morphology....
A key reason for the persistently grim statistics associated with metastatic ovarian cancer is resistance to conventional agents, including platinum-based chemotherapies. major source of treatment failure high degree genetic and molecular heterogeneity, which results from significant underlying genomic instability, as well stromal physical cues in microenvironment. Ovarian commonly disseminates via transcoelomic routes distant sites, frequent production malignant ascites, poorest prognosis....
Morbidity and mortality due to oral cancer in India are exacerbated by a lack of access effective treatments amongst medically underserved populations. We developed user-friendly low-cost, portable fibre-coupled LED system for photodynamic therapy (PDT) early lesions, using smartphone fluorescence imaging device treatment guidance, 3D printed fibreoptic attachments ergonomic intraoral light delivery.
Background Curcumin (CUR) and quercetin (QUE), two natural polyphenols, possess diverse biological activities including broad-spectrum antiviral, antioxidant, immunomodulatory effects. Both CUR QUE have shown inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro assays. Objective In the present study we aimed to assess possible treatment benefits a combined curcumin (CUR-QUE) oral supplement, alongside standard care (SOC), early-stage COVID-19 infection. Methods...
Background Photodynamic therapy (PDT) using δ‐aminolevulinic acid (ALA) photosensitization has shown promise in clinical studies for the treatment of early‐stage oral malignancies with fewer potential side effects than traditional therapies. Light delivery to lesions can also carried out limited medical infrastructure suggesting implementation PDT global health settings. Objectives We sought develop a cost‐effective, battery‐powered, fiber‐coupled system suitable intraoral light enabled by...
Colchicine has been proposed as a potential therapy in coronavirus disease 2019 (COVID-19) due to their anti-inflammatory actions.
India has one of the highest rates oral squamous cell carcinoma (OSCC) in world, with an incidence 15 per 100,000 and more than 70,000 deaths year. The problem is exacerbated by a lack medical infrastructure routine screening, especially rural areas. New technologies for cancer detection timely treatment at point care are urgently needed.
JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. JMJD6 reported catalyze hydroxylation of lysine residue(s) histones, the tumor-suppressor p53, regulatory proteins, u2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit (U2AF65). also N-demethylation N-methylated (both mono- di-methylated)...
Significance: India has one of the highest rates oral cancer incidence in world, accounting for 30% reported cancers. In rural areas, a lack adequate medical infrastructure contributes to unchecked disease progression and dismal mortality rates. Photodynamic therapy (PDT) emerged as an effective modality with potential treating early stage resource-limited settings, while photosensitizer fluorescence can be leveraged treatment guidance. Aim: Our aim was assess capability simple...
Anatomical and physiological considerations indicate that the oral cavity is a primary source of lung microbiota community, recent studies have shown in lungs contributes to immunological homeostasis, potentially altering organ's susceptibility viral infection, including SARS-CoV-2. It has been proposed that, case Gram-negative bacteria could promote cytokine cascade with better performance than mainly constituted by Gram-positive bacteria. Recent observations also suggest Prevotella-rich...