A5018519436- melanin and skin pigmentation
- Cutaneous Melanoma Detection and Management
- Genetic and rare skin diseases.
- Skin Protection and Aging
- Skin and Cellular Biology Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Melanoma and MAPK Pathways
- Allergic Rhinitis and Sensitization
- Telomeres, Telomerase, and Senescence
- Nonmelanoma Skin Cancer Studies
- Dermatological and Skeletal Disorders
- Medicine and Dermatology Studies History
- T-cell and B-cell Immunology
- T-cell and Retrovirus Studies
- Cell Image Analysis Techniques
- Mast cells and histamine
- Dermatological and COVID-19 studies
- Chronic Lymphocytic Leukemia Research
- Advanced Materials and Mechanics
- PI3K/AKT/mTOR signaling in cancer
Johannes Kepler University of Linz
2019-2025
Kepler Universitätsklinikum
2019-2024
Private University College of Education of the Diocese of Linz
2022
Medical University of Vienna
2016-2018
Vienna General Hospital
2018
Darier disease (DD) is a rare, inherited multi-organ disorder associated with mutations in the ATP2A2 gene. DD patients often have skin involvement characterized by malodorous, inflamed and recurrent, severe infections. Therapeutic options are limited inadequate for long-term management of this chronic disease. The aim study was to characterize cutaneous immune infiltrate lesions detail identify new therapeutic targets. Using gene protein expression profiling assays including scRNA...
Despite novel therapeutic options, the long-term management of cutaneous T cell lymphoma (CTCL) remains challenging. Extracorporeal photopheresis (ECP) is an immunomodulating photochemotherapy associated with higher overall survival when used for treatment leukemic forms CTCL. Its exact mode action not fully elucidated. Immunogenic death (ICD) pivotal in cancer immunotherapy, marked by release damage-associated molecular patterns that enhance dendritic (DC) maturation and cytotoxic...
Dupilumab is the first biological treatment approved for moderate-to-severe atopic dermatitis (AD). Efficacy and safety have been demonstrated in clinical trials, but real-life data still limited. The objective of this study was to retrospectively evaluate AD patients a setting. Effectiveness outcomes were collected at baseline after 2, 6, 10, 24, 39, 52 weeks by using scores disease activity, as well serological markers. Ninety-four from five dermatological hospitals included. After 24...
Abstract Osteogenesis imperfecta (OI) is a genetically and clinically heterogeneous disorder characterized by bone fragility reduced mass generally caused defects in type I collagen structure or proteins interacting with processing. We identified homozygous missense mutation SEC16B child vertebral fractures, leg bowing, short stature, muscular hypotonia, densitometric histomorphometric features keeping OI distinct ultrastructural features. In line the putative function of as regulator...
Abstract Cancer-associated immune dysfunction is a major challenge for effective therapies. The emergence of antibodies targeting tumor cell-surface antigens led to advancements in the treatment hematopoietic malignancies, particularly blood cancers. Yet their impact constrained against tumors origin manifesting skin. In this study, we employ clonality-supervised deep learning methodology dissect key pathological features implicated mycosis fungoides, most common cutaneous T-cell lymphoma....
The link between solar radiation and melanoma is still elusive. Although infrared (IR) accounts for over 50% of terrestrial energy, its influence on human skin not well explored. There increasing evidence that IR influences the expression patterns several molecules independently heat. A previous in vivo study revealed pretreatment with might promote development UVR-induced non-epithelial cancer possibly mice. To expand this, aim present was to evaluate impact apoptosis DNA repair normal...
Abstract Darier disease (DD) is a rare severe acantholytic skin caused by mutations in the ATP2A2 gene that encodes for sarco/endoplasmic reticulum calcium ATPase isoform 2 (SERCA2). SERCA2 maintains endoplasmic homeostasis pumping into ER, critical regulating cellular dynamics and function. To date, there no treatment specifically targets mechanisms DD. Dantrolene sodium (Dl) ryanodine receptor antagonist inhibits release from ER to increase levels currently used non-dermatological...
Checkpoint inhibitors revolutionized the treatment of metastatic melanoma patients. Although tumor burden and lactate dehydrogenase (LDH) are associated with overall survival (OS), impact growth kinetics remains elusive in part contradictory. The aims this study were to develop a novel simple rapid method that estimates pretreatment rate (MGR) investigate its prognostic patients treated antiprogrammed death receptor-1 (PD-1) antibodies.MGR was assessed three independent cohorts total 337...
The exact correlation between melanoma and sun-light is still a controversially debated issue. Although natural sunlight contains various ratios of UVA UVB, most investigators so far focused on the effects single solar wavebands neglected possible interactions. Therefore, in this study primary human melanocytes three donors were simultaneously exposed to physiologic doses UVA1 UVB. Effects apoptosis analysed using annexin V assays cell death ELISAs, DNA damage investigated southwestern slot...
Targeted therapy with the BRAF inhibitors vemurafenib and dabrafenib is an effective treatment regimen in patients advanced melanoma carrying V600E mutation. A common side effect enhanced rate of nonmelanoma skin cancer (NMSC). inhibition leads to a paradoxical MAPK signalling wild-type cells, which might part be responsible for NMSC burden. It known that disturbances DNA repair result increased NMSC. In present study, it was investigated whether interfere ultraviolet radiation-induced...
Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) has been proposed as curative approach for advanced cutaneous T – lymphomas (CTCL). Currently, there is no established consensus the management of disease relapse after alloHSCT. Results Ten patients, previously treated with multiple lines systemic treatment, received Six patients had achieved partial response (PR, N = 5) and complete (CR, 1) prior to HSCT. Post HSCT, seven (N 7) relapsed a median time 3.3 months (0.5...