A5030812101- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- S100 Proteins and Annexins
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Protein Degradation and Inhibitors
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Advanced Glycation End Products research
- Contact Dermatitis and Allergies
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Medical and Health Sciences Research
- Medical Imaging Techniques and Applications
- Genomics and Chromatin Dynamics
- Neuroblastoma Research and Treatments
- Genetic and rare skin diseases.
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Historical Legal Studies and Society
- Hedgehog Signaling Pathway Studies
Kantonsspital St. Gallen
2021-2024
University of Tübingen
2017-2023
University of St. Gallen
2019-2022
Heidelberg University
2014-2019
University Medical Centre Mannheim
2015-2019
University Hospital Heidelberg
2014-2019
German Cancer Research Center
2014-2019
Foundation for Human Potential
2015
Heinrich Heine University Düsseldorf
2008
Immunotherapy with PD-1 antibodies has greatly increased prognosis of patients advanced melanoma. Identifying biomarkers that predict overall survival (OS) and response to immunotherapy is important.OS best according RECIST version 1.1 were analysed, S100B lactate dehydrogenase (LDH) serum levels assessed retrospectively in 152 treated anti-PD-1, 86 anti-PD-1 plus anti-CTLA-4 at University Hospital Tuebingen, Germany.In the pembrolizumab group, elevated baseline or LDH exhibited...
Predicting metastasis in melanoma patients is important for disease management and could help to identify those who might benefit from adjuvant treatment. The aim of this study was investigate whether the tumor microenvironment-derived protein S100A8/A9 qualifies as prognostic marker patients, also setting immunotherapy.S100A8/A9 gene expression were analyzed on melanocytic nevi, primary melanomas metastases using a cDNA library three independent tissue-microarrays (TMA). Serum levels...
Background: PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemistry is increasingly used as diagnostic adjunct the evaluation of melanocytic tumors. The expression and prognostic significance PRAME melanomas ≤1.0 mm its utility distinction from severely dysplastic compound nevi (SDN) have not been studied. Methods: We investigated compared immunohistochemical 70 matched thin metastasizing non-metastasizing 45 patients with long-term follow-up (35 SDN 10 unequivocally benign...
At the early stages of COVID-19 outbreak in 2020, Switzerland was among countries with highest number SARS-CoV2-infections per capita world. Lockdowns had a remarkable impact on primary care access and resulted postponed cancer screenings. The aim this study to investigate effects lockdown diagnosis melanomas stage at diagnosis. In retrospective, exploratory cohort study, 1240 patients new melanoma were analyzed five tertiary hospitals German-speaking over period two years three months. We...
Background The need for reliable clinical biomarkers to predict which patients with melanoma will benefit from immune checkpoint blockade (ICB) remains unmet. Several different parameters have been considered in the past, including routine differential blood counts, T cell subset distribution patterns and quantification of peripheral myeloid-derived suppressor cells (MDSC), but none has yet achieved sufficient accuracy utility. Methods Here, we investigated potential cellular counts as well...
RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms (sRAGE and esRAGE) with clinical outcome melanoma patients. Moreover, tissue expression was analyzed using immunohistochemistry on two independent microarrays (TMA) containing 35 or 257 primary melanomas, 41 22 benign nevi, respectively. Serum concentrations sRAGE esRAGE were measured in 229 Stage III–IV patients ELISA plasma second cohort 173 samples I–IV In...
Immune checkpoint blockade with anti-PD-1 antibodies is showing great promise for patients metastatic melanoma and other malignancies, but despite good responses by some who achieve partial or complete regression, many others still do not respond. Here, we sought peripheral blood T-cell biomarker candidates predicting treatment outcome in 75 stage IV treated antibodies. We investigated associations clinical response, progression-free survival (PFS) overall (OS). Univariate analysis of...
Despite impressive response rates, most patients with advanced melanoma ultimately progress following therapy B-Raf proto-oncogene (BRAF) inhibitors (BRAFi). Therefore, frequent radiologic assessments are necessary, and reliable serum biomarkers would be beneficial for disease monitoring. This study investigated the ability of lactate dehydrogenase (LDH) S100 calcium-binding protein B (S100B) to detect progression during treatment BRAFi. Baseline levels LDH S100B repeated measurements were...
Background Anti-programmed cell death protein 1 (PD-1) antibodies are now routinely administered for metastatic melanoma and increasing numbers of other cancers, but still only a fraction patients respond. Better understanding the modes action predictive biomarkers clinical outcome is urgently required. Cancer rejection mostly T cell-mediated. We previously showed that presence NY-ESO-1-reactive and/or Melan-A-reactive cells in blood correlated with prolonged overall survival (OS)...
Abstract Background/Objectives Elevated neutrophil‐to‐lymphocyte ratio (NLR) in peripheral blood is associated with poor overall survival (OS) metastatic melanoma patients receiving immunotherapy. However, the impact of cells undergoing sentinel lymph node biopsy (SLNB) still unclear. This study was intended to characterize leukocytic on SLNB. Methods A total 1412 AJCC stage I‐II scheduled for SLNB at a single institution period 2010–2015 available perioperative tests were randomly assigned...
Checkpoint inhibitors revolutionized the treatment of metastatic melanoma patients. Although tumor burden and lactate dehydrogenase (LDH) are associated with overall survival (OS), impact growth kinetics remains elusive in part contradictory. The aims this study were to develop a novel simple rapid method that estimates pretreatment rate (MGR) investigate its prognostic patients treated antiprogrammed death receptor-1 (PD-1) antibodies.MGR was assessed three independent cohorts total 337...
Abstract Purpose Immune checkpoint inhibitor (ICI)-induced hepatitis belongs to the frequently occurring immune-related adverse events (irAEs), particularly with combination therapy involving ipilimumab and nivolumab. However, predisposing factors predicting occurrence of ICI-induced are barely known. We investigated association preexisting autoantibodies in development a prospective cohort cancer patients. Methods Data from biomarker comprising melanoma non-small cell lung (NSCLC) patients...
BackgroundHistopathologic regression of cutaneous melanoma is considered a favorable prognostic factor, but its significance in clinical practice remains controversial.ObjectiveTo investigate the importance patients with primary undergoing sentinel lymph node (SLN) biopsy and to assess progressing an unresectable stage requiring systemic therapy.MethodsWe retrospectively reviewed newly diagnosed SLN between 2010 2015 available information on histopathologic (n = 1179). Survival data...
In a prospective study of 132 cases gastroduodenal ulcer, proven by endoscopic biopsy, there were 59 in which fungi cultered (44.7%). There was no significant difference incidence between gastric ulcer (46.2%) and duodenal (42.6%), or benign malignant (47.2 42.1%, respectively). Most the yeasts genus Candida Torulopsis. The mycel phase demonstrable only native histological preparation (16.7% [native] 10.6% [histological] positive findings). all those pseudomycels demonstrated culture count...
Immune checkpoint blockade (ICB) is standard-of-care for patients with metastatic melanoma. It may re-invigorate T cells recognizing tumors, and several tumor antigens have been identified as potential targets. However, little known about the dynamics of antigen-specific in circulation, which might provide valuable information on ICB responses a minimally invasive manner. Here, we investigated individual signatures composed up to 167 different melanoma-associated epitope (MAE)-specific CD8+...
Abstract Background: In breast cancer diagnostics, the accurate assessment of HER2 status is essential for treatment stratification. Conventionally, immunohistochemistry (IHC) scoring necessitates specialized staining protocols, which are resource- and time-intensive. This study presents a virtual IHC (vIHC) digital assay to predict scores directly from hematoxylin eosin (H&E) stained images, routinely acquired all specimens. methodology aims accelerate standard practices by reducing...
TPS9617 Background: Basal cell carcinoma (BCC) and cutaneous squamous (cSCC) account for 99% of skin neoplasms, with a rising incidence due to increased sun exposure growing life expectancy. Approximately 0.8-5% patients (pts) develop high-risk locally advanced (LA) disease, which is treated surgery, radiotherapy, sonic hedgehog inhibitors, PD1-based immune checkpoint blockade, or chemotherapy. While surgery offers high cure rates, factors such as location, functional cosmetic impairment,...