A5005687258- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Chronic Kidney Disease and Diabetes
- Pregnancy and preeclampsia studies
- Dialysis and Renal Disease Management
- CAR-T cell therapy research
- Renal and Vascular Pathologies
- Birth, Development, and Health
- Virus-based gene therapy research
- Gestational Diabetes Research and Management
- Acute Kidney Injury Research
- Colorectal Cancer Treatments and Studies
- Viral Infections and Outbreaks Research
- Multiple Myeloma Research and Treatments
- Respiratory viral infections research
- Maternal and fetal healthcare
- Animal Genetics and Reproduction
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Treatments and Mutations
- Psoriasis: Treatment and Pathogenesis
- Xenotransplantation and immune response
- vaccines and immunoinformatics approaches
Kantonsspital St. Gallen
2021-2023
University of St. Gallen
2020
University of Liechtenstein
2015-2019
Labormedizinische Zentrum Dr Risch (Switzerland)
2015-2019
Tallinn University of Technology
2015-2016
Immune checkpoint inhibitors (ICIs) are among the most promising treatment options for melanoma and non-small cell lung cancer (NSCLC). While ICIs can induce effective anti-tumor responses, they may also drive serious immune-related adverse events (irAEs). Identifying biomarkers to predict which patients will suffer from irAEs would enable more accurate clinical risk-benefit analysis ICI shed light on common or distinct mechanisms underpinning success irAEs.In this prospective multi-center...
The ratio of cystatin C (cysC) to creatinine (crea) is regarded as a marker glomerular filtration quality associated with cardiovascular morbidities. We sought determine reference intervals for serum cysC-crea in seniors. Furthermore, we whether other low-molecular weight molecules exhibit similar behavior individuals altered quality. Finally, investigated associations adverse outcomes. A total 1382 subjectively healthy Swiss volunteers aged 60 years or older were enrolled the study....
Cancer treatment with immune checkpoint blockade (ICB) often induces immune-related adverse events (irAEs). We hypothesized that proteins coexpressed in tumors and normal cells could be antigenic targets irAEs herein described DITAS (discovery of tumor-associated self-antigens) for their identification. computed transcriptional similarity between lung healthy tissue based on single-sample gene set enrichment analysis. This identified 10 tissue–specific genes highly expressed the tumors....
QUESTION UNDER STUDY: The epidemiology of preeclampsia in Switzerland is known only from a retrospective registry study. This analysis aimed to prospectively determine the incidence cohort pregnant women Switzerland. METHODS: Pregnant presenting at gestational week 11–14 their obstetrician's office were consecutively included and followed-up until end pregnancy. Ultrasound characteristics, blood pressure measurements, body mass index, personal history recorded. Duration pregnancy, occurrence...
Early biochemical identification of women at high risk for the development pre-eclampsia (PE) is still unsatisfactory. Renal markers measured during first trimester were analysed to predict later occurrence PE. A nested case-control study was conducted within prospective predictive diagnosis preeclampsia study. Pregnant included end and followed up until birth. Controls matched PE cases. [i.e. creatinine, cystatin C (CysC), β2 microglobulin (B2M), β-trace protein (BTP), glomerular filtration...
Studies have shown positive effects of therapeutic exercise on motor- and cognitive function as well psychosocial outcomes in persons with multiple sclerosis (MS). A reduction inflammatory stress through physical has been suspected one key mechanism, mediating the context MS. The primary objective this trial is to investigate acute chronic different modalities (anti-)inflammatory immune signalling functional capacity two armed single-blind randomized controlled design will 72 relapsing...
Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal creatinine. Pregnant women with evidence SPS during first trimester have an increased risk developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized endothelial dysfunction. aim this nested case-control study was to establish first-trimester reference intervals (RI) for...
Abstract Purpose Immune checkpoint inhibitor (ICI)-induced hepatitis belongs to the frequently occurring immune-related adverse events (irAEs), particularly with combination therapy involving ipilimumab and nivolumab. However, predisposing factors predicting occurrence of ICI-induced are barely known. We investigated association preexisting autoantibodies in development a prospective cohort cancer patients. Methods Data from biomarker comprising melanoma non-small cell lung (NSCLC) patients...
The ratio of cystatin C to creatinine (cysC/crea) is regarded as a marker glomerular filtration quality and predicts mortality. It has been hypothesized that increased mortality may be mediated by the retention biologically active substances due shrinking pores. present study investigated whether cysC/crea independently associated with levels two renally cleared hormones, which have linked We conducted multicenter, cross-sectional random selection general practitioners (GPs) from all GP...
Immune checkpoint inhibitors (ICIs) have improved the survival of patients with non-small cell lung cancer (NSCLC) by reinvigorating tumor-specific T responses. However, specificity such cells and human leukocyte antigen (HLA)-associated epitopes recognized, remain elusive. In this study, we identified NSCLC recently described NSCLC-associated antigens, termed keratinocyte differentiation antigens. Epitopes these antigens were presented HLA-A 03:01 HLA-C 04:01 associated responses to ICI...
Harnessing the immune system to eradicate tumors requires identification and targeting of tumor antigens, including tumor-specific neoantigens tumor-associated self-antigens. Tumor-associated antigens are subject existing tolerance, which must be overcome by immunotherapies. Despite many novel immunotherapies reaching clinical trials, inducing self-antigen-specific responses remains challenging. Here, we systematically investigate viral-vector-based cancer vaccines encoding a self-antigen...
Abstract Breaking self-tolerance and inducing a robust immune response targeting tumor cell derived self-antigens by therapeutic vaccines has remained challenging. We have generated replicating viral vector based on the arenavirus lymphocytic choriomeningitis virus expressing melanoma tissue-specific self-antigen Trp2 (artLCMV-Trp2) show that single immunization of mice bearing established with this can break tolerance against self antigen induces high levels tumor-infiltrating TRP2+ CD8+ T...