A5082952206- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cutaneous Melanoma Detection and Management
- Autoimmune Bullous Skin Diseases
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Hidradenitis Suppurativa and Treatments
- Spondyloarthritis Studies and Treatments
- Nail Diseases and Treatments
- Drug-Induced Adverse Reactions
- Complementary and Alternative Medicine Studies
- Cutaneous lymphoproliferative disorders research
- Mast cells and histamine
- Colorectal and Anal Carcinomas
- Fibromyalgia and Chronic Fatigue Syndrome Research
- AI in cancer detection
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Skin Protection and Aging
- Autoimmune and Inflammatory Disorders
- Infection Control and Ventilation
University of Zurich
2017-2025
University Hospital of Zurich
2016-2025
University of Freiburg
2024
University Medical Center Freiburg
2024
Novartis (Switzerland)
2023
Drexel University
2023
University of South Florida
2023
Helsinki University Hospital
2023
Technical University of Munich
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
Abstract This evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following EuroGuiDerm Guideline Consensus Statement Development Manual. The first part includes general information scope purpose, health questions covered, target users strength/limitations guideline. Suggestions for disease severity grading goals are provided. It presents recommendations as well detailed management monitoring individual drugs. options discussed in this follows:...
Abstract This evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following EuroGuiDerm Guideline Consensus Statement Development Manual. The second part provides guidance for specific clinical comorbid situations such as treating patient with concomitant psoriatic arthritis, inflammatory bowel disease, a history malignancies or depression suicidal ideation. It further holds recommendations diabetes, viral hepatitis, disease affecting heart kidneys...
Pyoderma gangrenosum (PG) is a rare, neutrophilic, ulcerative skin disease that difficult to treat, especially when unresponsive steroids.To determine whether canakinumab an effective and safe treatment in PG.Five adult patients with clinically histologically confirmed steroid-refractory PG were enrolled this prospective open-label study. They received 150 mg subcutaneously at week 0 optional 2 case of inadequate response [Physician's Global Assessment (PGA) ≥ 2], 150-300 8 depending on PGA....
Though patient needs are key drivers of treatment decisions, they rarely systematically investigated in routine care.This study aimed at analysing and expectations from the perspective German Swiss psoriasis registries PsoBest Dermatology Network Targeted Therapies (SDNTT) with respect to choice, age gender.The observe patients recruited first-time use systemic drugs. Within 10 years, clinical [Psoriasis Area Severity Index (PASI), Body Surface (BSA)] patient-reported outcomes documented,...
Dry skin is a frequent and multifaceted condition which can be associated with irritation, itch, patient discomfort manifest disease. In spite of being frequent, little known about the epidemiology dry in population.To determine prevalence German adult population.Data 48 630 employed persons were assessed on cross-sectional level whole-body examinations by experienced dermatologists during company-based screenings conducted 343 companies. Next to current dermatologic findings, age, gender,...
Abstract Background Artificial intelligence (AI) shows promising potential to enhance human decision‐making as synergistic augmented (AuI), but requires critical evaluation for skin cancer screening in a real‐world setting. Objectives To investigate the perspectives of patients and dermatologists after by human, artificial intelligence. Methods A prospective comparative cohort study conducted at University Hospital Basel included 205 (at high‐risk developing melanoma, with resected or...
The exponential increase in algorithm-based mobile health (mHealth) applications (apps) for melanoma screening is a reaction to growing market. However, the performance of available apps remains be investigated. In this prospective study, we investigated diagnostic accuracy class 1 CE-certified smartphone app risk stratification and its patient dermatologist satisfaction. Pigmented skin lesions ≥ 3 mm any suspicious smaller were assessed by SkinVision® (SkinVision® B.V., Amsterdam,...
Convolutional neural networks (CNNs) have outperformed dermatologists in classifying pigmented skin lesions under artificial conditions. We investigated, for the first time, performance of three-dimensional (3D) and two-dimensional (2D) CNNs early detection melanoma a real-world setting.In this prospective study, 1690 melanocytic 143 patients with high-risk criteria were evaluated by dermatologists, 2D-FotoFinder-ATBM 3D-Vectra WB360 total body photography (TBP). Excision was based on...
Quality of life impairment in dermatology patients and severity psoriasis are quantified by the Dermatology Life Index (DLQI) Psoriasis Area Severity (PASI), respectively. The aim this study is to compare correlation between PASI DLQI from different geographical areas identify predictors high across regions. Correlations were evaluated using Spearman’s rank tests quantile regression. included 1,158 with psoriasis, a median (interquartile range) 6.0 (3.0–12.0) 8.0 (4.0–15.0), demonstrated...
Abstract Background Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by widespread eruption of sterile pustules with or without systemic symptoms. Objectives This study aimed to describe the demographics patients GPP in Central and Eastern Europe (CEE), present clinical characteristics individual flares explore current treatment landscape. Methods Patient were collected at times last observation previous treatment. Characteristics patient's (most...
This nationwide cohort study included 452 patients (873 treatment series) and reported drug survival data on with hidradenitis suppurativa treated biologics such as adalimumab, infliximab, ustekinumab secukinumab. The median time for adalimumab was approximately 8 months, but bio-naïve had a significantly longer compared non-naïve patients.
Epidermal growth factor receptor (EGFR) and MEK inhibitors (EGFRi/MEKi) are beneficial for the treatment of solid cancers but frequently associated with severe therapy-limiting acneiform skin toxicities. The underlying molecular mechanisms poorly understood. Using gene expression profiling we identified IL-36γ IL-8 as candidate drivers EGFRi/MEKi toxicity. We provide translational evidence that in concert commensal bacterium Cutibacterium acnes act synergistically to induce keratinocytes...
BACKGROUND: Seborrhoeic dermatitis is a common but epidemiologically poorly researched chronic skin disease. OBJECTIVES: To characterize the prevalence and dermatological comorbidity of seborrhoeic in Germany. METHODS: In course voluntary company checks, full-body examinations were carried out more than 500 companies by experienced dermatologists documented electronically. RESULTS: In total, 161 269 participants included (men 55·5%, mean age 43·2 ± 10·9 years). Seborrhoeic was...
Few systematic data on sex-related treatment responses exist for psoriasis. To evaluate sex differences with respect to systemic antipsoriatic treatment. Data from patients moderate-to-severe psoriasis in the PsoBest or Swiss Dermatology Network of Targeted Therapies (SDNTT) registries were analysed. Treatment response was defined as achieving a ≥ 75% reduction Psoriasis Area and Severity Index (PASI 75) PASI ≤ 3 at months 3, 6 12, supplemented by patient-reported outcomes [i.e. Life Quality...
Topical treatment is crucial for the successful management of plaque psoriasis. Topicals are used either as a stand-alone therapy mild psoriasis or else in combination with UV systemic moderate-to-severe disease. For choice suitable topical treatment, formulation matters and not just active substances. This expert opinion paper was developed via non-structured consensus process by Swiss dermatologists hospitals private practices to illustrate current options general practitioners...
The real-world efficacy of biologics may be insufficiently assessed through common drug survival studies. objective was thus to examine the performance in treatment psoriasis using composite endpoint either discontinuation or off-label dose escalation. Using a prospective nationwide registry (DERMBIO, 2007-2019), we included patients with treated adalimumab, secukinumab, and/or ustekinumab, which have all been used as first-line therapy during inclusion period. primary escalation treatment,...
Importance The COVID-19 pandemic resulted in delayed access to medical care. Restrictions health care specialists, staff shortages, and fear of SARS-CoV-2 infection led interruptions routine care, such as early melanoma detection; however, premature mortality economic burden associated with this postponement have not been studied yet. Objective To determine the costs suspended screenings during lockdowns by estimating total diagnoses for Europe. Design, Setting, Participants This multicenter...
Pregnancy-associated changes in melanocytic nevi (MN), apart from size increase on the trunk, remain a topic of debate. We conducted first prospective study to investigate dermoscopic MN comparing pregnant with non-pregnant women all body parts using market-approved convolutional neural network (CNN). included 25 and Basel, Switzerland, who underwent standard skin cancer screenings whose > 2 mm were digitally recorded analysed by CNN. Pregnant examined three times: third trimester 8-12 weeks...
ABSTRACT Background The epidemiology of chronic hand eczema (CHE) remains poorly examined. Objective To investigate the prevalence CHE in a general adult population and describe characteristics affected individuals. Methods We investigated using random sample from Danish (The Skin Cohort). was defined as on hands or wrists during minimum three consecutive months reoccurrence at least twice within 12 months. Results Out 11 166 adults, 1306 experienced (HE) some point their lifetime. Within...