A5072986763- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Cancer and Skin Lesions
- dental development and anomalies
- American Environmental and Regional History
- Genetic and rare skin diseases.
- Asthma and respiratory diseases
- NF-κB Signaling Pathways
- Hedgehog Signaling Pathway Studies
- Pregnancy and Medication Impact
- Rangeland and Wildlife Management
- Cervical Cancer and HPV Research
- Autoimmune Bullous Skin Diseases
- Hair Growth and Disorders
- Archaeology and Natural History
- Infectious Diseases and Mycology
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Spondyloarthritis Studies and Treatments
Aarhus University Hospital
2017-2024
Aarhus University
2023-2024
Abstract This evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following EuroGuiDerm Guideline Consensus Statement Development Manual. The first part includes general information scope purpose, health questions covered, target users strength/limitations guideline. Suggestions for disease severity grading goals are provided. It presents recommendations as well detailed management monitoring individual drugs. options discussed in this follows:...
Abstract This evidence‐ and consensus‐based guideline on the treatment of psoriasis vulgaris was developed following EuroGuiDerm Guideline Consensus Statement Development Manual. The second part provides guidance for specific clinical comorbid situations such as treating patient with concomitant psoriatic arthritis, inflammatory bowel disease, a history malignancies or depression suicidal ideation. It further holds recommendations diabetes, viral hepatitis, disease affecting heart kidneys...
Ectodermal dysplasias constitute a group of rare genetic disorders the skin and appendages with hypodontia, hypotrichosis, hypohidrosis as cardinal features. There is lack population-based research into epidemiology ectodermal dysplasias.
BackgroundIκBζ plays a key role in psoriasis by mediating IL-17A–driven effects, but the molecular mechanism which IL-17A regulates IκBζ expression is not clarified.ObjectiveWe sought to explore transformation patients with during anti-IL-17A (secukinumab) treatment focus on IκBζ.MethodsThe study was an open-label, single-arm, single-center secukinumab that included 14 plaque psoriasis. Skin biopsy specimens and blood samples were collected days 0, 4, 14, 42, 84 processed for microarray gene...
Abstract IL-37 broadly suppresses inflammation in various disease models. However, studies of the regulation and role psoriasis are limited contradictive. Using transcriptome analysis, PCR, protein determination, immunofluorescence, we demonstrated marked downregulation biopsies from human lesional skin compared with paired samples nonlesional skin. Immunofluorescence analysis showed that was localized to stratum granulosum epidermis. TNF-α stimulation normal epidermal keratinocytes led...
Hailey-Hailey disease (OMIM#169600) is an autosomal dominantly inherited genodermatosis characterized by erosions in the flexural areas of body. caused variants ATP2C1, but for ~10% patients, no causative variant found coding region ATP2C1. We aimed to determine genetic cause a family without By genome sequencing and analysis all exon intron sequences we identified c.532-560 T>G (NM_014382.5) 7 The predicted silico tools create new deep intronic donor splice site. Segregation detected three...