A5004610695- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Cancer therapeutics and mechanisms
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Drug Transport and Resistance Mechanisms
- Ovarian cancer diagnosis and treatment
- RNA Interference and Gene Delivery
- Bioactive Compounds and Antitumor Agents
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Optical Imaging and Spectroscopy Techniques
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Advanced Fluorescence Microscopy Techniques
- Connective tissue disorders research
- Click Chemistry and Applications
- PARP inhibition in cancer therapy
- Tendon Structure and Treatment
Arizona State University
2008-2025
University of Maryland, College Park
2018-2025
University of Maryland, Baltimore
2019-2025
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2019-2025
National Institutes of Health
2024
National Cancer Institute
2024
U-M Rogel Cancer Center
2021-2024
Massachusetts General Hospital
2008-2020
Harvard University
2008-2020
Abstract Background Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC selectivity and uptake is a major drawback limiting the efficacy photoimmunotherapy. Despite ample evidence showing that photoimmunotherapy most effective when combined with chemotherapy, design nanocarriers to co-deliver PICs chemotherapy drugs remains unmet need....
Plasmonic nanoparticles have shown promise in hyperthermic cancer therapy, both vitro and vivo. Previous reports described ablation using targeted nontargeted internalized by cells, but most do not describe a theoretical analysis for determining optimal parameters. The focus of the current research was first to evaluate spatiotemporal temperature distribution cell death induced extracellular hyperthermia which gold nanorods (GNRs) were maintained dispersion outside human prostate cells....
The propensity of nanoparticles to aggregate in aqueous media hinders their effective use biomedical applications. Gold nanorods (GNRs) have been investigated as therapeutics, imaging agents, and diagnostics. We report that chemically generated gold rapidly biologically relevant media. Depositing polyelectrolyte multilayers on enhanced the stability these for at least up 4 weeks. Dispersions (PE)-gold nanorod assemblies (PE−GNRs) demonstrate a stable Arrhenius-like photothermal response,...
Abstract The ability of tumor cells to adapt therapeutic regimens by activating alternative survival and growth pathways remains a major challenge in cancer therapy. Therefore, the most effective treatments will involve interactive strategies that target multiple nonoverlapping while eliciting synergistic outcomes minimizing systemic toxicities. Nanoliposomal irinotecan is approved FDA for gemcitabine-refractory metastatic pancreatic cancer. However, full potential treatment hindered several...
Abstract Physiologic barriers to drug delivery and selection for resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve the tumor microenvironment safely widen therapeutic window of nanoformulated cytotoxic drug. orthotopic xenograft models pancreatic cancer, combining PDP with nanoliposomal irinotecan (nal-IRI) prevented relapse, reduced metastasis, increased both...
Abstract Glioblastoma (GBM) is hard to treat due cellular invasion into functioning brain tissues, limited drug delivery, and evolved treatment resistance. Recurrence nearly universal even after surgery, chemotherapy, radiation. Photodynamic therapy (PDT) involves photosensitizer administration followed by light activation generate reactive oxygen species at tumor sites, thereby killing cells or inducing biological changes. PDT can ablate unresectable GBM sensitize tumors chemotherapy....
Resistance of cancer cells to hyperthermic temperatures and spatial limitations nanoparticle-induced hyperthermia necessitates the identification effective combination treatments that can enhance efficacy this treatment. Here we show novel polypeptide-based degradable plasmonic matrices be employed for simultaneous administration chemotherapeutic drugs as an treatment overcome cell resistance hyperthermia.Novel gold nanorod elastin-like polypeptide were generated characterized. The also...
Approximately 1.5 million people suffer from colorectal cancer and inflammatory bowel disease in the United States. Occurrence of leakage following standard surgical anastomosis intestinal surgery is common can cause infection leading to life-threatening consequences. In this report, we demonstrate that plasmonic nanocomposites, generated elastin-like polypeptides (ELPs) cross-linked with gold nanorods, be used weld ruptured tissue upon exposure near-infrared (NIR) laser irradiation....
Abstract The past three decades have witnessed notable advances in establishing photosensitizer–antibody photo‐immunoconjugates for photo‐immunotherapy and imaging of tumors. Photo‐immunotherapy minimizes damage to surrounding healthy tissue when using a cancer‐selective photo‐immunoconjugate, but requires threshold intracellular photosensitizer concentration be effective. Delivery immunoconjugates the target cells is often hindered by I) low photosensitizer‐to‐antibody ratio II) limited...
A key reason for the persistently grim statistics associated with metastatic ovarian cancer is resistance to conventional agents, including platinum-based chemotherapies. major source of treatment failure high degree genetic and molecular heterogeneity, which results from significant underlying genomic instability, as well stromal physical cues in microenvironment. Ovarian commonly disseminates via transcoelomic routes distant sites, frequent production malignant ascites, poorest prognosis....
Patients with cancer often confront the decision of whether to continue high-dose chemotherapy at expense cumulative toxicities. Reducing dose regimens while preserving efficacy is sorely needed preserve performance status these vulnerable patients, yet has not been prioritized. Here, we introduce a dual pronged approach modulate microenvironment desmoplastic pancreatic tumors and enable significant deescalation FDA-approved chemotherapeutic nanoliposomal irinotecan (nal-IRI) without...
Abstract Background: There are limited data on the incidence, distribution, and prognosis of colorectal peritoneal metastasis. However, some studies have suggested that metastasis has a worse other sites Therefore, this study assessed epidemiology categories in United States. Methods: The incidence-based SEER database was used to identify patients with metastatic adenocarcinoma diagnosed from 2018-2021. Extent disease staging variables were determine Demographic treatment included as...