A5002417486- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Click Chemistry and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Porphyrin and Phthalocyanine Chemistry
- Pancreatic and Hepatic Oncology Research
- Nanocluster Synthesis and Applications
- Advanced Radiotherapy Techniques
- Monoclonal and Polyclonal Antibodies Research
- Luminescence Properties of Advanced Materials
- Radiation Therapy and Dosimetry
- Nitric Oxide and Endothelin Effects
- Advanced Fluorescence Microscopy Techniques
- Optical Coherence Tomography Applications
- Ocular Oncology and Treatments
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal and Macular Surgery
Université Grenoble Alpes
2018-2025
Inserm
2018-2025
Centre National de la Recherche Scientifique
2018-2025
Massachusetts General Hospital
2016-2022
Harvard University
2016-2022
Agir Pour les Maladies Chroniques
2020
Institut de Biosciences et Biotechnologies
2018-2020
European Synchrotron Radiation Facility
2020
Institut pour l'avancée des biosciences
2018-2019
Harvard University Press
2018
Oxidative stress, a state in which intra- or extracellular oxidant production outweighs the antioxidative capacity, lies at basis of many diseases. DCFH2-DA (2',7'-dichlorodihydrofluorescein diacetate) is most widely used fluorogenic probe for detection general oxidative stress. However, use DCFH2-DA, as other redox probes, mainly confined to intracellular stress vitro. To expand applicability probe, an alkaline hydrolysis and solvent extraction procedure was developed generate high-purity...
Despite untiring efforts to develop therapies for pancreatic ductal adenocarcinoma (PDAC), survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming (PDP), which improves drug delivery and combination regimens, as well tumor photodestruction are key attributes of photodynamic therapy (PDT), making it a distinctive clinical option PDAC. Localized, high-payload nanomedicine-assisted photosensitizers (PSs), with molecular specificity controlled photoactivation,...
Abstract To improve the prognosis of glioblastoma, innovative radiotherapy regimens are required to augment effect tolerable radiation doses while sparing surrounding tissues. In this context, nanoscintillators emerging radiotherapeutics that down‐convert X‐rays into photons with energies ranging from UV near‐infrared. During radiotherapy, these scintillating properties amplify radiation‐induced damage by UV‐C emission or photodynamic effects. Additionally, contain high‐Z elements likely...
Raspberry ketone is an important compound for the flavour industry. It frequently used in products such as soft drinks, sweets, puddings and ice creams. The can be produced by organic synthesis. Demand "natural" raspberry growing considerably. However, this product extremely expensive. Consequently, there a remaining desire to better understand how synthesized vivo, which genes enzymes are involved. With information we will then position design alternative production strategies microbial...
// Ruud Weijer 1, 2, * , Mans Broekgaarden Massis Krekorian 1 Lindy K. Alles Albert C. van Wijk Claire Mackaaij 3 Joanne Verheij Allard der Wal Thomas M. Gulik Gert Storm 4 Michal Heger Department of Experimental Surgery, Academic Medical Center, University Amsterdam, 1105 AZ The Netherlands 2 Controlled Drug Delivery, MIRA Institute for Biomedical Technology and Technical Medicine, Twente, 7500 AE Enschede, Pathology, Pharmaceutics, Utrecht Pharmaceutical Sciences, Utrecht, 3584 CG These...
Bioengineered three-dimensional (3D) tumor models that incorporate heterotypic cellular communication are gaining interest as they can recapitulate key features regarding the intrinsic heterogeneity of cancer tissues. However, architectural complexity and heterogeneous contents associated with these pose a challenge for toxicological assays to accurately report treatment outcomes. To address this issue, we describe comprehensive image analysis procedure structurally complex organotypic...
Patients with cancer often confront the decision of whether to continue high-dose chemotherapy at expense cumulative toxicities. Reducing dose regimens while preserving efficacy is sorely needed preserve performance status these vulnerable patients, yet has not been prioritized. Here, we introduce a dual pronged approach modulate microenvironment desmoplastic pancreatic tumors and enable significant deescalation FDA-approved chemotherapeutic nanoliposomal irinotecan (nal-IRI) without...
Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on the nuclear of slow neutrons by stable 10B atoms followed charged particle emission that inducing extensive damage very localized level (<10 μm). To be efficient, sufficient amount should accumulate in tumor area while being almost cleared from normal surroundings. A water-soluble aza-boron-dipyrromethene dyes (BODIPY) fluorophore was reported to strongly with high and BNCT compatible Tumor/Healthy Tissue ratios....
Background: Photodynamic therapy (PDT) has been successfully used to treat various solid tumors. However, some cancer types respond poorly PDT, including urothelial carcinomas, nasopharyngeal and extrahepatic cholangiocarcinomas. The therapeutic recalcitrance is in part due the use of photosensitizers with suboptimal optical/ photochemical properties unfavorable pharmacokinetics. Objective: To circumvent these drawbacks, a secondgeneration photosensitizer improved optical/photochemical...
// Mans Broekgaarden 1 , Imran Rizvi Anne-Laure Bulin Ljubica Petrovic 2 Ruth Goldschmidt Iqbal Massodi Jonathan P. Celli and Tayyaba Hasan Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA Physics, University Massachusetts, 02125, Correspondence to: Hasan, email: thasan@mgh.harvard.edu Keywords: translational therapies; organoid models; experimental medicine; combination therapy; photochemotherapy...
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy the site-specific conjugation single domain antibodies onto liposomes containing photosensitizer zinc phthalocyanine was developed and tested.
// Anne-Laure Bulin 1 , Mans Broekgaarden Diane Simeone 2, 3, 4 and Tayyaba Hasan Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA 2 Surgery, NYU Langone Health, New York, NY, 3 Perlmutter Cancer Center, Pathology, Correspondence to: Bulin, email: anne-laure.bulin@esrf.fr Hasan, thasan@mgh.harvard.edu Keywords: low dose photodynamic therapy; radiation spheroids; pancreatic cancer Received: November 16, 2018...
Gold nanoclusters (AuNC) have strong potential for cancer imaging and therapy. We demonstrate that optimizing the surface chemistry of AuNCs increased tumor uptake can significantly affect its to augment radiotherapy outcomes.
Photodynamic therapy (PDT) of solid cancers comprises the administration a photosensitizer followed by illumination photosensitizer-replete tumor with laser light. This induces state local oxidative stress, culminating in destruction tissue and microvasculature induction an anti-tumor immune response. However, some types, including perihilar cholangiocarcinoma, are relatively refractory to PDT, which may be attributable activation survival pathways cells following PDT (i.e., activator...