A5018138282- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Reproductive tract infections research
- Bioactive Compounds and Antitumor Agents
- Intraperitoneal and Appendiceal Malignancies
- Cancer Cells and Metastasis
- bioluminescence and chemiluminescence research
- Synthesis and biological activity
- Ocular Oncology and Treatments
- Estrogen and related hormone effects
- Bladder and Urothelial Cancer Treatments
- Bacterial Infections and Vaccines
- Mathematical Biology Tumor Growth
- Heme Oxygenase-1 and Carbon Monoxide
- Histone Deacetylase Inhibitors Research
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- Photochromic and Fluorescence Chemistry
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Nanoparticle-Based Drug Delivery
University of Maryland, College Park
2019-2021
Massachusetts General Hospital
2017-2020
Harvard University
2017-2020
Norwegian University of Science and Technology
2011-2017
Abstract Background Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC selectivity and uptake is a major drawback limiting the efficacy photoimmunotherapy. Despite ample evidence showing that photoimmunotherapy most effective when combined with chemotherapy, design nanocarriers to co-deliver PICs chemotherapy drugs remains unmet need....
Abstract Physiologic barriers to drug delivery and selection for resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve the tumor microenvironment safely widen therapeutic window of nanoformulated cytotoxic drug. orthotopic xenograft models pancreatic cancer, combining PDP with nanoliposomal irinotecan (nal-IRI) prevented relapse, reduced metastasis, increased both...
Patients with cancer often confront the decision of whether to continue high-dose chemotherapy at expense cumulative toxicities. Reducing dose regimens while preserving efficacy is sorely needed preserve performance status these vulnerable patients, yet has not been prioritized. Here, we introduce a dual pronged approach modulate microenvironment desmoplastic pancreatic tumors and enable significant deescalation FDA-approved chemotherapeutic nanoliposomal irinotecan (nal-IRI) without...
Antimicrobial resistance in Neisseria gonorrhoeae is a major issue of public health, and there critical need for the development new antigonococcal strategies. In this study, we investigated effectiveness antimicrobial blue light (aBL; wavelength, 405 nm), an innovative nonpharmacological approach, inactivation N. gonorrhoeae. Our findings indicated that aBL preferentially inactivated gonorrhoeae, including antibiotic-resistant strains, over human vaginal epithelial cells vitro. Furthermore,...
Background and Objectives The aim of this study was to investigate the efficacy, safety, mechanism action antimicrobial blue light (aBL) for inactivation Neisseria gonorrhoeae , etiological agent gonorrhea. Study Design/Materials Methods susceptibilities N. (ATCC 700825) in planktonic suspensions aBL at 405‐ 470‐nm wavelengths were compared. roles oxygen anti‐gonococcal activity studied by examining effects hypoxic condition (blowing N 2 ) on efficiency 405‐nm aBL. presence, identification,...
Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are as pro-drugs to induce formation potent photosensitizer protoporphyrin IX (PpIX). Activation PpIX by light causes reactive oxygen species (ROS) toxic responses. Studies have indicated that its methyl ester (MAL) taken up into cells via γ-butyric (GABA) transporters (GATs). Uptake GATs peripheral sensory nerve endings may...
Mechanism-inspired drug repurposing that augments standard treatments offers a cost-effective and rapid route toward addressing the burgeoning problem of plateauing effective therapeutics for drug-resistant micrometastases. We show antibiotic minocycline, by its ability to minimize DNA repair via reduced expression tyrosyl-DNA phosphodiesterase-1 (Tdp1), removes key process attenuating efficacy irinotecan, frequently used chemotherapeutic against metastatic disease. Moreover, minocycline...
Photosensitizing biomolecules (PSBM) represent a new generation of light-absorbing compounds with improved optical and physicochemical properties for biomedical applications. Despite numerous advances in lipid-, polymer-, protein-based PSBMs, their effective use requires fundamental understanding how macromolecular structure influences the biological photosensitizer. Here, we prepared characterized three well-defined PSBMs based on clinically used photosensitizer, benzoporphyrin derivative...
Bleomycin is a cytotoxic chemotherapeutic agent widely used in cancer treatment. However, its efficacy different cancers low, possibly due to limited cellular internalization. In this study, novel approach known as photochemical internalization (PCI) was explored enhance bleomycin delivery bladder cells (human T24 and rat AY-27), potential indication for use of PCI with bleomycin. The technique mediated by the amphiphilic photosensitizer disulfonated tetraphenyl chlorin (TPCS 2a ) blue light...
The combination of photodynamic therapy and taxol- or platinum-based chemotherapy (photochemotherapy) is an effective promising cancer treatment. While the mechanisms action photochemotherapy are actively studied, relatively little known about cytotoxicity molecular alterations induced by photosensitizers without light activation in cells. This study investigates interplay between photosensitizer benzoporphyrin derivative (BPD) cisplatin paclitaxel two glioblastoma lines, U87 U251. effect...
P-glycoprotein (P-gp) is an adenosine triphosphate (ATP)-dependent drug efflux protein commonly associated with multidrug resistance in cancer chemotherapy. In this report, we used a dual-fluorescent co-culture model to study the population dynamics of sensitive human ovarian cell line (OVCAR-8-DsRed2) and its resistant subline that overexpresses P-gp (NCI/ADR-RES-EGFP) during course photodynamic therapy (PDT)-olaparib combination regimen. Without treatment, OVCAR-8-DsRed2 cells grew more...
<p>Sub-tumouricidal PDP does not increase systemic toxicity of chemotherapy. Changes in mouse body weight were monitored longitudinally before and after treatment.</p>
<div>Abstract<p>Physiologic barriers to drug delivery and selection for resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve the tumor microenvironment safely widen therapeutic window of nanoformulated cytotoxic drug. orthotopic xenograft models pancreatic cancer, combining PDP with nanoliposomal irinotecan (nal-IRI) prevented relapse, reduced metastasis,...
<p>The effect of combination PDP and nal-IRI on tumour growth inhibition is synergistic in orthotopic MIA PaCa-2 mouse model.</p>
<p>Relationship between primary tumour weight and distant metastatic burden during disease progression.</p>
<p>Sub-tumouricidal PDP does not increase systemic toxicity of chemotherapy. Changes in mouse body weight were monitored longitudinally before and after treatment.</p>
<p>The effect of combination PDP and nal-IRI on tumour growth inhibition is synergistic in orthotopic MIA PaCa-2 mouse model.</p>
<p>Endpoint primary metastatic burdens were comparable mice treated with 'nal-IR' and 'PDT + nal-IRI'.</p>
<p>Endpoint primary metastatic burdens were comparable mice treated with 'nal-IR' and 'PDT + nal-IRI'.</p>