A5089088185- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer therapeutics and mechanisms
- Job Satisfaction and Organizational Behavior
- Photodynamic Therapy Research Studies
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Digital Marketing and Social Media
- Cancer, Hypoxia, and Metabolism
- Customer Service Quality and Loyalty
- Cancer Cells and Metastasis
- Knowledge Management and Sharing
- Technology Adoption and User Behaviour
- Muscle Physiology and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Neurogenetic and Muscular Disorders Research
- Workplace Spirituality and Leadership
- Cyberloafing and Workplace Behavior
- Emotional Labor in Professions
- Cardiomyopathy and Myosin Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- bioluminescence and chemiluminescence research
University of Dayton
2021-2024
The University of Texas Rio Grande Valley
2022-2023
Lebanese American University
2023
University of Minnesota, Duluth
2023
La Salle University
2019-2022
Scholar Rock (United States)
2018-2021
Merrimack Pharmaceuticals (United States)
2009-2019
Creative Commons
2018
Rubius Therapeutics (United States)
2017
The University of Texas at Arlington
2017
Computational modeling of the ErbB signaling network affirms ErbB3 as a therapeutic target.
Inhibiting a specific isoform of TGFβ augments the effectiveness checkpoint blockade therapy in cancer treatment.
A major challenge in the clinical use of cytotoxic chemotherapeutics is maximizing efficacy tumors while sparing normal tissue. Irinotecan used for colorectal cancer treatment but extent its limited by toxic side effects. Liposomal delivery systems offer tools to modify pharmacokinetic and safety profiles drugs. In this study, we defined parameters that maximize antitumor activity a nanoliposomal formulation irinotecan (nal-IRI). mouse xenograft model human colon carcinoma, nal-IRI dosing...
Abstract Physiologic barriers to drug delivery and selection for resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve the tumor microenvironment safely widen therapeutic window of nanoformulated cytotoxic drug. orthotopic xenograft models pancreatic cancer, combining PDP with nanoliposomal irinotecan (nal-IRI) prevented relapse, reduced metastasis, increased both...
Liposomal drug packaging is well established as an effective means for increasing half-life, sustaining activity, and efficacy, whether administered locally or distally to the site of disease. However, information regarding relative effectiveness peripheral (distal) versus local administration liposomal therapeutics limited. This issue importance with respect treatment central nervous system cancer, which blood-brain barrier presents a significant challenge in achieving sufficient...
Immunotherapy has increasingly become a staple in cancer treatment. However, substantial limitations the durability of response highlight need for more rational therapeutic combinations. The aim this study is to investigate how make tumor cells sensitive T-cell-based immunotherapy.Two pairs melanoma patient-derived cell lines and their autologous tumor-infiltrating lymphocytes were utilized high-throughput screen 850 compounds identify bioactive agents that could be used combinatorial...
Purpose This study examines the contextual variables that can curb negative effects of role conflict on job satisfaction and enhance positive effect creativity service performance. More specifically, adopting demands-resources theory, authors explore interactive frontline employee (FLE) self-monitoring FLE-manager trust relationship between satisfaction. Extending this line inquiry, adopt social identity theory analyze moderating identification Design/methodology/approach Dyadic data...
Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody under development to improve motor function in patients with spinal muscular atrophy, a rare neuromuscular disease. This phase 1 double-blind, placebo-controlled study assessed safety, pharmacokinetic parameters, pharmacodynamics (serum latent myostatin), and immunogenicity of single multiple ascending doses apitegromab healthy adult subjects. Subjects were administered intravenous 1, 3, 10, 20, 30 mg/kg or placebo, placebo....
Abstract While social media has become an integral part of modern‐day life, it is a largely overlooked topic in supply chain business‐to‐business setting. This study utilizes dyadic survey data collected from both supplier account managers and their customers to explore media's impacts the digitalized context. Drawing upon knowledge‐based view firm, proposes tests conceptual model. Results indicate that manager's use can increase his or her product competitor knowledge, which positively...
Dynamic business environments can cause unexpected disruptions that force firms to embrace new ways of working. In such situations, salesforce change agility be a key success. However, scant research has examined the factors promote development agility, or consequences thereof. We address these notable omissions by using sample 237 B2B salespeople explore effect idiosyncratic deals on work absorption, behavioral performance, and sales performance. The findings indicate salesperson's...
Scholars have recently explored the effects of salespeople's intraorganizational relationships on job-related outcomes. Grounded in social influence theory, we explore skills salesperson relationship performance. We empirically tested proposed using data from a non-Western sales force working with an organization emerging economy. The results indicate that political skill positively contributes to identification and creative performance, while strikingly, also find task adaptivity weakens...
Purpose Although the role of internal competitive work environment is important, it remains understudied in a business-to-business (B2B) selling context. Grounded job-demands resources theory, this study aims to investigate relationships between environment, working smart, emotional exhaustion and sales performance. Design/methodology/approach Data were gathered from 147 salespeople for financial service firm. Sales performance ratings reported by supervisors. Hypotheses tested using...
While the benefits of salesforce creativity are well-documented, recent calls underscore lack research on how to develop a creative salesforce. Adopting social learning theory, we position ethical leadership as focal antecedent performance. Using this theoretical lens, construct model that explores two moderators and one mediator in relationship. Analyzing survey responses from salespeople, reveal enhances power, which turn, increases Results also show job autonomy strengthens positive...
Mucins are high molecular weight glycoproteins expressed on the apical surface of normal epithelial cells. In cancer disease mucins overexpressed entire cellular surface. Overexpression MUC1 mucin in pancreatic tumours has been correlated with poor patient survival. Current chemotherapeutic approaches such as 5-fluorouracil (5-FU) produced limited clinical success. this study we investigated role cytotoxic drug treatment to determine whether extracellular domain impedes action 5-FU. Human...
Context: This study presents novel nanostructured oil-in-water (o/w) mists based on self-nanoemulsifying (SNE) mixtures capable of delivering poorly water-soluble drugs into the lungs.Objective: Formulation development an o/w nanoemulsion (NE) being nebulized for pulmonary delivery drugs.Materials and methods: SNE were prepared evaluated using Tween 80 Cremophor RH 40 as surfactants; Transcutol P, Capryol 90 PEG 400 cosurfactants; Labrafac Lipophile Wl 1349 (a medium-chain triglyceride) oil....
Liposomal irinotecan (irinotecan liposome injection, nal-IRI), a liposomal formulation of irinotecan, is designed for extended circulation relative to and exploiting discontinuous tumor vasculature enhanced drug delivery tumors. Following deposition, nal-IRI taken up by phagocytic cells followed release conversion its active metabolite, SN-38. Sustained inhibition topoisomerase 1 SN-38 exposure as result hypothesized enable superior antitumor activity compared with traditional inhibitors...