The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According the solubility studies DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as excipients. Pseudo-ternary phase diagrams constructed, then SNEDDS formation assessment SNEDDSs formulations performed. loaded prepared characterized. optimum DFX-SNEDDS developed. relative safety optimized formulation examined human immortalized...

Aprepitant (APR) belongs to Class II of the Biopharmaceutical Classification System (BCS) because its low aqueous solubility. The objective current work is develop self-nanoemulsifying drug delivery systems (SNEDDS) APR enhance Preformulation studies involving screening excipients for solubility and emulsification efficiency were carried out. Pseudo ternary phase diagrams constructed with blends oil (Imwitor® 988), cosolvent (Transcutol® P), various surfactants (Kolliphor® RH40, Kolliphor®...

Fungal ocular infections can cause serious consequences, despite their low incidence. It has been reported that Posaconazole (PSC) is used in the treatment of fungal different tissues by diluting oral suspension, and successful results were obtained permeation. Therefore, we optimized PSC-loaded micelles demonstrated permeation/penetration PSC was enhanced.The micellar-based situ gels based on QbD approach to increase bioavailability developed. Different ratios Poloxamer 407 188 chosen as...

One of the crucial approaches to managing low solubility and weak bioavailability drugs is via nanocrystal technology. Through this technology, drug particles have an increased a faster dissolution rate due high surface free energy, which requires appropriate stabilizer(s) prevent instabilities during manufacturing process storage nanosuspension. This study aimed establish scientific predictive system for properly selecting stabilizers or reduce attempts on trial-and-error basis in...

Abstract Aim To evaluate clinical and biochemical effects of adjunctive systemic folic acid (FA) intake with scaling root planing (SRP) in periodontitis treatment. Materials methods Sixty subjects (30 per group) were randomly assigned into study groups treated either SRP + placebo (SRP P) or F). In addition to parameters (plaque index [PI], gingival [GI], probing pocket depth [PPD], attachment level [CAL] recession [GR]), crevicular fluid (GCF) samples obtained at baseline post‐treatment...

Aprepitant is the first member of a relatively new antiemetic drug class called NK1 receptor antagonists. It commonly prescribed to prevent chemotherapy-induced nausea and vomiting. Although it included in many treatment guidelines, its poor solubility causes bioavailability issues. A particle size reduction technique was used commercial formulation overcome low bioavailability. Production with this method consists successive steps that cause cost increase. This study aims develop an...

This mini-review theoretically illustrates the in silico methods used pharmacy field to enhance drug discovery and development reduce preclinical studies. It is shown that are computational-based approaches study structure, properties, activities of molecules using computer simulations mathematical algorithms. These results highlight importance obtaining data can affect prediction vivo results. Artificial intelligence machine learning such as quantitative structure-activity relationship,...

Technological advancements have led to the development of wearable devices that can be integrated into everyday accessories, clothing, or attached skin.These serve as electronic monitoring tools wirelessly synchronize with smartphones computers for long-term data tracking.Wearable find applications not only in healthcare but also sports and clothing industries, allowing easy tracking various tasks storing personal data.The increasing adoption technologies offers benefits such improved...

Abstract: Recent changes and limited resources for drug development manufacturing have rendered the conventional pharmaceutical quality assurance approach insufficient given rise to new research in these areas. To address efforts, FDA improved modernized rules governing product 2002, thereby realizing a paradigm change current Good Manufacturing Practices (cGMP). The Quality by Design (QbD) has entered industry within last 10 years after approval of ICH Q8 2005. QbD is based on an...

The objective of the current study was to develop an optimized formulation for orally disintegrating tablets (ODTs) containing melatonin.Different particle sizes mannitol (i.e., filler) were used effects on dissolution and tablet properties using a quality by design (QbD) approach.The target product profile identified, then critical attributes (CQAs) determined.Risk assessment performed Failure Mode Effect Analysis (FMEA) method identify rank material process parameters.Thirty-four...

In this study, within the framework of Quality by Design which is a systematically scientific approach enables to understand and control production formulation variables during process design development, different parameters in were detected critical material attributes determined via risk evaluation methods.Then, oral disintegrating tablet formulations prepared tested changing usage co-formulated excipient other disintegrant combined with sodium starch glycolate mannitol.Powder flow...

Orally disintegrating tablets (ODTs) can be utilized without any drinking water; this feature makes ODTs easy to use and suitable for specific groups of patients. Oral administration drugs is the most commonly used route, constitute preferable pharmaceutical dosage form. However, preparation costly requires long trials, which creates obstacles trials. The aim study was identify appropriate formulation using machine learning (ML) models ODT dexketoprofen formulations, with goal providing a...

This design study was implemented within the scope of quality by approach, which included "International Conference on Harmonization" guidelines. We evaluated a modified-release tablet formulation quetiapine fumarate, designed using artificial neural networks (ANN), and determined new that similar to reference product.Twelve different formulations were produced tested. The product's results our experimental used as outputs for training ANN programs Intelligensys Ltd.Dissolution tests...

Although the first application of Quality by Design (QbD) concept started for product development studies, number studies regarding its to analytical has been increased recently. Basically, QbD strategy in both formulation and analytic are identical logically conceptually, but they have somedifferences terms terminology application. Essential approach differences this are; determination target profile, critical method characteristics, process parameters, study area. However, risk evaluation...

Self-emulsifying systems (SEEDS) are becoming increasingly popular for the preparation of oral dosage forms low-water-soluble drugs. SEEDS divided into subgroups according to their components; type IV formulations that prepared using only surfactants and/or co-surfactants. The aim study was increase solubility tadalafil, a class II drug BCS, by preparing formulation. In study, Labrasol, Kolliphor PS 20, 60, 80, CS 12, HS 15, EL, ELP, PEG400, Gelucire 44/14 and 48/16 were used as surfactants;...

The objective of this study was to develop and validate the stability-indicating method for newly developed Extended-Release tablet formulation Ranolazine.First, new Ranolazine developed.These tablets were analyzed by using a High-Performance Liquid Chromatography system with UV detector at 220 nm wavelength C8-3 column (150 mm x 4.6 i.d; 5 μm particle size).The injection volume 10 μl.The validation parameters; Selectivity, linearity, accuracy, robustness, precision limit quantification...

Lipophilic drugs which are poorly water soluble need specific applications like lipid based delivery systems to increase their oral absorption across gastrointestinal tract.Selfnanoemulsifying drug Lipid Based Drug Delivery (SNEEDs) and consists of an isotropic mixture oil, surfactant(s) co-surfactant.This prepared at room temperature with gentle stirring process without using any other component or heating become nanoemulsion form upon agitation in aqueous phase.SNEDDs have many advantages...