A5012548897- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Trace Elements in Health
- Per- and polyfluoroalkyl substances research
- Vitamin C and Antioxidants Research
- Nanoparticle-Based Drug Delivery
- Electrochemical Analysis and Applications
- Natural product bioactivities and synthesis
- Anesthesia and Neurotoxicity Research
- Redox biology and oxidative stress
- Porphyrin and Phthalocyanine Chemistry
- Drug-Induced Hepatotoxicity and Protection
- Air Quality and Health Impacts
- Mycotoxins in Agriculture and Food
- Synthesis and biological activity
- Carcinogens and Genotoxicity Assessment
- Photodynamic Therapy Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Sulfur Compounds in Biology
- Pesticide Exposure and Toxicity
- Inflammatory mediators and NSAID effects
- Electrochemical sensors and biosensors
Istanbul University
2015-2025
Lyon College
2025
Altınbaş University
2023
Karadeniz Technical University
2016-2021
Istanbul University-Cerrahpaşa
2019
Turkish Academy of Sciences
2017
Worldwide researchers have rising concerns about magnesium-based materials, especially magnesium oxide (MgO) nanaoparticles, due to increasing usage as promising structural materials in various fields including cancer treatment. However, there is a serious lack of information their toxicity at the cellular and molecular levels. In this study, toxic potentials MgO nanoparticles were investigated on liver (HepG2), kidney (NRK-52E), intestine (Caco-2), lung (A549) cell lines. For toxicological...
The wide uses of zinc oxide nanoparticles (nano-ZnO) in industrial, cosmetics, medicine, food production and electronics associate with increase occupational public exposure. Although, toxicity nano-ZnO has been extensively studied on many different cell types animal systems, there is a significant lack toxicological data focus nephrotoxic potential nano-ZnO. In this study, the cyto- genotoxic effects rat kidney epithelial cells (NRK-52E) were investigated by using assays. Nano-ZnO (10–50 nm...
There has been an increased interest in standardized approaches to coding facial movement mammals. Such include Facial Action Coding Systems (FACS), where individuals are trained identify discrete muscle movements that combine create a configuration. Some studies have utilized FACS analyze signaling, recording the quantity of morphologically distinct signals species can generate. However, it is unclear whether these numbers represent total number combinations (which we refer as...
The use of synthetic cannabinoids (SCs) increases dramatically among youth from different cultures. UR-144 is one these SCs that was reported in 2012 for its first abuse. Case reports show neuronal toxicity symptoms after exposure and a few laboratory studies cell death, apoptosis, oxidative stress lines. However, none those evaluate the cells. In this study, it hypothesized induces human neuroblastoma (SH-SY5Y) To test that, MTT neutral red uptake (NRU) assays were performed to...
Purpose: The wide application of cupric oxide nanoparticles (copper (II) oxide, CuO-NPs) in various fields has increased exposure to the kind active nanomaterials, which can cause negative effects on human and environment health. Although CuO-NPs were reported be harmful human, there is still a lack information related their toxic potentials. In present study, potentials evaluated liver (HepG2 hepatocarcinoma) intestine (Caco-2 colorectal adenocarcinoma) cells. Methods: After...
Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, constituents of herbs potentially toxic and pose health risks because they can be bought the market without prescription. Therefore, we aimed to determine safety possessing aphrodisiac effects, chosen on basis frequency medicinal use commercial importance in Turkey. Materials methods: Ten (Anethum...
Abstract Objectives To determine of antioxidant, cytotoxic and tyrosinase inhibitory (TI) activities, phenolic profiles with a new high performance liquid chromatography (HPLC) method green, white black teas. Methods Antioxidant activities the teas were examined by means scavenging free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), cupric capacity (CUPRAC). The contents investigated HPLC. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...
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Cobalt oxide (Co 3 O 4 ) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the of Co on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung gastrointestinal, Caco-2 colorectal adenocarcinoma nervous system, SH-SY5Y neuroblastoma cells. A difference was observed sensitivity toward nanoparticles. were taken up by all types. However, no...
Context: Tribulus terrestris L. (Zygophyllaceae) has been commonly used to energize, vitalize, and improve sexual function physical performance in men.Objective: This study investigates the potential cytotoxic genotoxic, endocrine disrupting activities of T. vitro.Materials methods: The whole plant was extracted with water, methanol, chloroform. genotoxic extracts at 3–2400 µg/mL assessed by Comet assay a rat kidney cell line (NRK-52E) Ames Salmonella typhimurium TA98 TA100 strains....
Lanthanum nanoparticles are widely used in industry, agriculture, and biomedicine. Over 900 kg of lanthanum is annually released into the environment only Europe, 50 times higher than metals, mercury, cadmium's environmental spread. Human health risk associated with long-term exposure to abundant a concerning issue. Due lanthanum's ability disrupt main biological barriers interrupt various cells' hemostasis, they seem cause severe disruptions tissues. This review opens new perspective...
Citrinin (CIT) is a mycotoxin produced as secondary product by the genera Aspergillus, Penicillium, Monascus, and other strains. CIT has potential for contaminating animal feed human food such maize, wheat, rye, barley, oats, rice, cheese, sake. Although primarily known nephrotoxic mycotoxin, it also affects organs, including liver bone marrow, its mechanisms of toxicity have not been clearly elucidated. There further lack studies investigating CIT-induced neurotoxicity mechanisms. In...
The remarkable properties of hard magnetic cobalt ferrite nanoparticles (CoFe2O4-NPs) and their physicochemical stability lead to various applications in different industrial medical fields. Although CoFe2O4-NPs have been reported cause toxic effects, there is a serious lack information concerning effects on the kidneys. In this study, it was aimed investigate NRK-52E kidney cells.The particle characterisation cellular uptake were determined using transmission electron microscopy, dynamic...
The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, fruits collected from Türkiye (Balıkesir İstanbul) were identified in present study.Different parts V. EO's in-vitro cytotoxic effects on MCF-7 (human breast adenocarcinoma) A549 lung carcinoma) human-origin cell lines anaylzed current study.The composition hydrodistiled EOs extracted analyzed by GC-FID/MS.Monoterpene hydrocarbons oxygenated monoterpene compounds...