A5023695084- Insect and Pesticide Research
- Molecular Sensors and Ion Detection
- Vitamin C and Antioxidants Research
- Chemotherapy-induced organ toxicity mitigation
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Advanced biosensing and bioanalysis techniques
- PI3K/AKT/mTOR signaling in cancer
- Medicinal Plant Extracts Effects
- Endoplasmic Reticulum Stress and Disease
- Chemotherapy-induced cardiotoxicity and mitigation
- biodegradable polymer synthesis and properties
- Drug Transport and Resistance Mechanisms
- Natural Compounds in Disease Treatment
- Insect Pest Control Strategies
- Advancements in Transdermal Drug Delivery
- Forensic Toxicology and Drug Analysis
- Histone Deacetylase Inhibitors Research
- Pancreatitis Pathology and Treatment
- Glutathione Transferases and Polymorphisms
- Dendrimers and Hyperbranched Polymers
- Genomics, phytochemicals, and oxidative stress
- Oral health in cancer treatment
- Cancer Mechanisms and Therapy
- Cannabis and Cannabinoid Research
Istanbul University-Cerrahpaşa
2023-2025
Istanbul University
2017-2024
İstanbul Eğitim ve Araştırma Hastanesi
2020
Abstract Acetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one the most widely used neonicotinoids. There limited data about toxicity acetamiprid on male reproductive system. Therefore, study aimed to investigate toxic potential in rats orally treated with low (12.5 mg/kg) medium (25 or high dose (35 for 90 days. According our results, sperm concentration and plasma testosterone levels decreased dependent manner. Gonadotropin-releasing hormone (GnRH),...
Abstract Inappropriate disposal of plastic wastes and their durability in nature cause uncontrolled accumulation land/marine ecosystems, also causing destructive effects by bioaccumulating along the food chain. Microplastics may chronic inflammation relation to permanent structures, especially through oxidative stress cytotoxic cellular damage, which could increase risk cancer development. The microplastics liver is a major concern, therefore, identification mechanisms hepatotoxic great...
The use of synthetic cannabinoids (SCs) increases dramatically among youth from different cultures. UR-144 is one these SCs that was reported in 2012 for its first abuse. Case reports show neuronal toxicity symptoms after exposure and a few laboratory studies cell death, apoptosis, oxidative stress lines. However, none those evaluate the cells. In this study, it hypothesized induces human neuroblastoma (SH-SY5Y) To test that, MTT neutral red uptake (NRU) assays were performed to...
Acetamiprid, a selective agonist of type-2 nicotinic acetylcholine receptors, is one the most widely used neonicotinoids. The hepato- and nephrotoxic potential acetamiprid has not been clarified although it known to be toxic other several organ systems, including nervous, respiratory immune systems. present study aimed investigate liver kidney toxicity in male rats after 90-day subchronic exposure 12.5, 25 35 mg/kg. biochemical oxidative damage parameters were determined plasma tissue...
Acetamiprid (ACE), a commonly used neonicotinoid insecticide, is correlated with neurological symptoms, immunotoxicity and hepatotoxicity. Cellular stress damage could play an important role in ACE-induced neurotoxicity; however, its mechanism has not been fully understood. We evaluated the effects of ACE on oxidative stress, endoplasmic reticulum (ER) cellular death, mRNA expression levels related genes protein expressions molecular mechanisms SH-SY5Y human neuroblastoma cells. The half...
Zoledronic acid, a nitrogen-containing bisphosphonate drug, is used for the treatment of osteoporosis, Paget's disease bone, and tumor-induced osteolysis. acid has also gained place in cancer due to its cytotoxic antiproliferative effects many cells. Although zoledronic considered safe, kidney damage still one concerns therapeutic doses. In study, aim was assess nephrotoxic profiles human embryonic (HEK-293) Cytotoxicity evaluation performed by...
Valerenic acid (VA) is a sesquiterpenoid and phytoconstituent of the plant valerian used for sleeping disorders anxiety. The frequency using herbal components as therapeutic nutritional agents has increased lately. Their ability to improve redox homeostasis makes them valuable approach against harmful xenobiotics. purpose this study was evaluate putative beneficial role VA redox-perturbating fungicide benomyl in HepG2 human liver cells terms oxidative stress cellular environment endoplasmic...
The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatographyhigh resolution mass spectrometry (LC-HRMS), and investigate antioxidant cytotoxic activities plant. Cytotoxic activity was evaluated MTT assay, apoptosis induction abilities on human prostate adenocarcinoma (PC-3), hepatocellular carcinoma (Hep G2) cell lines. Accordingly, major were found as hederagenin (762 ± 70.10 μg/g) in leaves dichloromethane (LD), herniarin (167 1.50...
Abstract Celastrol is a natural bioactive compound extracted from the medicinal plant Tripterygium wilfordii Hook F. It exhibits immunosuppressive, anti-inflammatory, and antioxidant activities. Cisplatin commonly used chemotherapeutic drug in treatment of wide range tumors. Although very effective therapeutically, it can cause nephrotoxicity leading to dose reduction or discontinuation treatment. This study aims clarify therapeutic potential celastrol cisplatin-induced nephrotoxicity. The...
Lesinurad is a drug used for the treatment of hyperuricemia.It has been reported that lesinurad causes renal adverse events.The molecular effects in kidney cells have not elucidated clearly.The embryonic (HEK-293) were treated with at various concentrations (12.5-100 µM) 24h.The cytotoxicity, apoptotic effect, reactive oxygen species (ROS), lipid peroxidation (MDA), and total antioxidant capacity (TAC) levels evaluated.Secretion inflammatory mediators was examined after...
PARP-1 (poly(ADP-ribose)-polymerase 1) inhibitors are vital in synthetic lethality, primarily due to their specificity for over PARP-2 (PARP-1 > PARP-2). This is crucial as it allows precise inhibition of tumor cells with Breast Cancer 1 protein (BRCA1) or BRCA2 deficiencies. The development highly specific not only meets the therapeutic needs treatment but also has potential minimize adverse effects associated nonselective inhibition. In this study, a series novel...