A5066223503- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Genetics, Bioinformatics, and Biomedical Research
- Mosquito-borne diseases and control
- Nanoplatforms for cancer theranostics
- CRISPR and Genetic Engineering
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Estrogen and related hormone effects
- Psoriasis: Treatment and Pathogenesis
- Synthesis and Biological Evaluation
- PARP inhibition in cancer therapy
- Boron and Carbon Nanomaterials Research
- RNA and protein synthesis mechanisms
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Sulfur Compounds in Biology
- Bioactive Compounds and Antitumor Agents
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
Bahçeşehir University
2021-2025
Yeditepe University
2018-2022
Adnan Menderes University
2022
Bilkent University
2022
Abdullah Gül University
2022
Istanbul University
2022
Akdeniz University
2022
Ordu University
2022
Justus-Liebig-Universität Gießen
2022
Istanbul Medipol University
2022
Abstract Interleukin‐23 (IL‐23) is a dominant cytokine in psoriasis, chronic inflammatory skin disease that severely diminishes patients' quality of life and reduces lifespan by up to 10 years. Despite therapeutic advancements, psoriasis remains clinical challenge due the absence definitive cure, treatment side effects, substantial economic burden. Notably, no small molecule inhibitors (SMIs) directly targeting IL‐23 have been developed date, leaving critical gap current therapies. In this...
Cancer remains a critical global health challenge, necessitating advanced drug delivery systems through innovations in materials science and nanotechnology. This study evaluates Gadolinium Metal‐Organic Frameworks (Gd‐MOFs) as potential for anticancer therapy, particularly when combined with radiotherapy. Gd‐MOFs were synthesized using terephthalic acid gadolinium (III) chloride hexahydrate, then loaded methotrexate (MTX). Characterization via FTIR, TGA, DSC, MRI, XRD confirmed their correct...
Background: c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence. Objective: Targeting modulators HSC quiescence could lead to cycle entry with concomitant expansion. Methods Results: Here we show that inhibitor 10074-G5 treatment leads 2-fold increase murine LSKCD34low compartment post 7 days. In addition, inhibition increases CD34+ CD133+ human number. downregulation cyclindependent kinase (CDKI) gene expression ex vivo vivo....
Meis1, which belongs to TALE-type class of homeobox gene family, appeared as one the key regulators hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors MEIS1 remained unknown. This led us develop that could modulate HSC activity. To this end, we have established library relevant family developed high-throughput in silico screening strategy against homeodomain MEIS proteins using AutoDock Vina PaDEL-ADV platform. We screened over...
Abstract Background Cancer remains a formidable global health challenge, currently affecting nearly 20 million individuals worldwide. Due to the absence of universally effective treatments, ongoing research explores diverse strategies combat this disease. Recent efforts have concentrated on developing combined drug regimens and targeted therapeutic approaches. Objective This study aimed investigate anticancer efficacy conjugated system, consisting doxorubicin cisplatin (Dox‐Cis),...
Abstract Breast cancer has the second highest death toll in women worldwide, despite significant progress early diagnosis and treatments. The main cause of is metastatic disease. Matrix metalloproteinases (MMP) are required for initial steps metastasis, have therefore been considered as ideal pharmacologic targets antimetastatic therapy. However, clinical trials MMP inhibitors were unsuccessful. These conducted patients with advanced disease, beyond stage when these compounds could...
Eukaryotic elongation factor 2 kinase (eEF2K) has been shown to be an important molecular driver of tumorigenesis and validated as a potential novel target in various solid cancers including triple negative breast cancer (TNBC).
Abstract Cancer is anticipated to become the pioneer reason of disease‐related deaths worldwide in next two decades, underscoring urgent need for personalized and adaptive treatment strategies. These strategies are crucial due high variability drug efficacy tendency cancer cells develop resistance. This study investigates potential theranostic nanotechnology using three innovative fluorescent polymers (FP‐1, FP‐2, FP‐3) encapsulated niosomal carriers, combining therapy (chemotherapy...
: The role of the gut microbiome in development and progression many diseases has received increased attention recent years. Boron, a trace mineral found dietary sources, attracted interest due to its unique electron depletion coordination characteristics chemistry, as well potential modulating microbiota. This study investigates effects inorganic boron derivatives on microbiota mice.
OTU proteases antagonize the cellular defense in host cells and involve pathogenesis. Intriguingly, P. falciparum, vivax, yoelii have an uncharacterized highly conserved viral OTU-like proteins. However, their structure, function or inhibitors not been previously reported. To this end, we performed structural modeling, small molecule screening, deconjugation assays to characterize develop first-in-class of These Plasmodium proteins residues catalytic inhibition pockets similar demonstrated...
<title>Abstract</title> Synthetic lethality, involving the simultaneous deactivation of two genes, plays a critical role in disrupting vital cellular functions or prompting cell death. This study delves into impact synthetic lethality within cancer research, specifically examining interplay between Focal Adhesion Kinase (FAK) and Neurofibromin 2 (NF2) genes. While deactivating FAK NF2 individually has minimal impact, their combined highlights significance lethal interaction. Hence, principal...
PARP-1 (poly(ADP-ribose)-polymerase 1) inhibitors are vital in synthetic lethality, primarily due to their specificity for over PARP-2 (PARP-1 > PARP-2). This is crucial as it allows precise inhibition of tumor cells with Breast Cancer 1 protein (BRCA1) or BRCA2 deficiencies. The development highly specific not only meets the therapeutic needs treatment but also has potential minimize adverse effects associated nonselective inhibition. In this study, a series novel...
Abstract: Cancer is one of the biggest global health problems and second leading cause death worldwide. also causes great damage to economy. Unfortunately, there still no effective treatment method against this disease today, mortality rates in certain types are very high. Medical research can now be done faster safer with aid silico studies. These studies save time for researchers accelerate new drug discoveries. In our study, thiophene derivatives important efficacy cancer were focused on...
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized screened for their anti-inflammatory activities H 2 S-releasing capacities. Compounds I1 I1c demonstrated the most potent selective COX-2 inhibition.
Synthetic lethality, involving the simultaneous deactivation of two genes, disrupts cellular functions or induces cell death. This study examines its role in cancer, focusing on focal adhesion kinase and Neurofibromin 2. Inhibiting FAK, crucial for synthetic lethality with NF2/Merlin, offers significant cancer treatment potential. No FAK inhibitor has been clinically approved, underscoring need new, effective inhibitors. The small-molecule inhibitors identified this show promise, SP docking,...
Abstract Meis1 , which belongs to TALE-type class of homeobox gene family, appeared as one the key regulators hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors MEIS1 remained unknown. This led us develop that could modulate HSC activity. To this end, we have established library relevant family developed high-throughput in silico screening strategy against homeodomain MEIS proteins using AutoDock Vina PaDEL-ADV platform. We...
c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence. Targeting modulators HSC quiescence could lead to cycle entry with concomitant expansion. Here we show that inhibitor 10074-G5 treatment leads 2-fold increase murine LSKCD34low compartment post 7 days. In addition, inhibition increases CD34+ CD133+ human number. downregulation cyclin-dependent kinase (CDKI) gene expression ex vivo vivo. upregulates HDR modulator Rad51 cells....
OTU proteases are key proteins of intracellular parasites that antagonize the cellular defenses following entry into host cells. Intriguingly, three parasitic plasmodium species causing malaria have uncharacterized viral protein-like proteins. However, structure, function or inhibitors these OTU-like not been previously reported. We performed modeling, drug screening, deconjugating assays and determined novel P.falciparum, P.vivax, P.yoelii species. Malarial (mOTU) activities were shown by...
The annual MolBiyoKon congress is organized by the Molecular Biology Association of Turkey and one primary noteworthy international conferences in field molecular biology Turkey.The aims to bring together scientists from all around world disseminate research results exchange ideas, as well motivate inspire students pursue their careers education life sciences.This year's hosts 15 speakers Turkey.There are more than 450 participants different backgrounds practices sciences.The covers diverse...