A5025848157- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fatty Acid Research and Health
- Cardiac and Coronary Surgery Techniques
- Inflammatory mediators and NSAID effects
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Natural Products and Biological Research
- Receptor Mechanisms and Signaling
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Infant Health and Development
- Botanical Studies and Applications
- Neurological Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
Istanbul University
2015-2025
Bursa Uludağ Üni̇versi̇tesi̇
2023
Centre National de la Recherche Scientifique
2004-2006
Sorbonne Université
2004-2006
Université Paris Cité
2005
Hôpital Broussais
2004-2005
Reduced synthesis of nitric oxide (NO) contributes to the endothelial dysfunction and may be related limited availability l-arginine, common substrate constitutive nitric-oxide synthase (NOS) cytosolic arginase I mitochondrial II. To determine whether arginases modulate NO synthesis, we investigated effects competitive inhibitor <i>N</i><sup>ω</sup>-hydroxy-nor-l-arginine (Nor-NOHA) on activity NOS, arginases, l-arginine transporter release at surface human umbilical vein cells (HUVECs). In...
The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular system could be associated with reduced prostaglandin (PG)I2 synthesis. Microsomal PGE synthase-1 (mPGES-1) catalyses formation PGE2 from COX-derived PGH2 . This enzyme is induced under inflammatory conditions and constitutes an attractive target for novel anti-inflammatory drugs. However, it not known whether mPGES-1 devoid effects. aim this study was to compare, in vitro, COX-2 vascular tone human blood...
Hydrogen sulfide (H2S) is a mediator with demonstrated protective effects for the cardiovascular system. On other hand, prostaglandin (PG)E2 involved in vascular wall remodeling by regulating matrix metalloproteinase (MMP) activities. We tested hypothesis that endogenous H2S may modulate PGE2, MMP-1 activity and tissue inhibitors of MMPs (TIMP-1/-2). This regulatory pathway could be thinning abdominal aortic aneurysm (AAA) thickening saphenous vein (SV) varicosities. The expression enzyme...
Vascular dysfunction plays a key role in the pathogenesis of diabetic vascular disease. In this study, we aimed to investigate whether chronic vivo treatment Crataegus microphylla ( CM ) extract rats induced with streptozotocin (STZ, intraperitoneal, 65 mg/kg) preserves function and evaluate reduction inducible nitric oxide synthase (iNOS), proinflammatory cytokines, lipid peroxidation mediates its mechanisms action. Starting at 4 weeks diabetes, (100 was administrated for weeks. aortic...
The oxidation of plasma LDLs (low-density lipoproteins) is a key event in the pathogenesis atherosclerosis. LPC (lysophosphatidylcholine) and oxysterols are major lipid constitutents oxidized LDLs. In particular, 7-oxocholesterol has been found from cardiac patients atherosclerotic plaque. present study, we investigated ability to regulate activation eNOS (endothelial nitric oxide synthase) cPLA2 (cytosolic phospholipase A2) that synthesize two essential factors for vascular wall integrity,...
Endothelial membrane-bound thrombomodulin is a high affinity receptor for thrombin to inhibit coagulation. We previously demonstrated that the thrombin-thrombomodulin complex restrains cell proliferation mediated through protease-activated (PAR)-1. have now tested hypothesis transduces signal activate endothelial nitric-oxide synthase (NOS3) and modulate G protein-coupled signaling. Cultured human umbilical vein cells were stimulated with or mutant of binds has no catalytic activity on...
It has been reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces endothelial inflammation, therefore facilitating the progression of and vascular dysfunction in disease 2019 (COVID-19) patients.Coronary artery bypass grafting (CABG) involves mainly use saphenous vein (SV) internal mammary as graft material stenosed coronary arteries.Unfortunately, patency SV is low due to inflammation.We propose SARS-CoV-2 might cause dysfunction, thrombosis vessels by...
High levels of fructose in the diet results metabolic abnormalities and vascular disorders. In this study, effect resveratrol (RES) on relaxation contraction responses was examined aorta high-fructose (HFr)-fed rats. mRNA expressions aortic sirtuin 1 (SIRT1), GLUT5, aldolase B were also investigated. Rats given (30%) (or) RES (50 mg · L(-1)) their drinking water for 8 weeks. HFr-fed rats, plasma arginine ratio arginine:asymmetric dimethylarginine (ADMA) decreased, whereas leptin increased....
Preeclampsia is characterized by hypertension and proteinuria developing after 20 weeks of gestation. Increased vasoconstriction can be one the major underlying pathophysiological event in this syndrome. We examined role vasoconstrictor prostanoid, prostaglandin F2α (PGF2α) preeclamptic normotensive human umbilical veins.Umbilical veins were set up organ bath. The concentration-response curves PGF2α (endogenous agonist F receptor) fluprostenol (prostaglandin receptor selective agonist)...