A5040763960- Nitric Oxide and Endothelin Effects
- Cardiac and Coronary Surgery Techniques
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience and Neuropharmacology Research
- Cardiac Valve Diseases and Treatments
- Adenosine and Purinergic Signaling
- Renin-Angiotensin System Studies
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Biochemical effects in animals
- Electrolyte and hormonal disorders
- Anesthesia and Neurotoxicity Research
- Cardiovascular Disease and Adiposity
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- Cardiovascular Issues in Pregnancy
- Heart Rate Variability and Autonomic Control
- Nerve injury and regeneration
University College London
2012-2023
Centre for Inflammation Research
2009-2023
The Royal Free Hospital
2011-2021
Roland Hill (United Kingdom)
2005-2018
Children's Cancer and Leukaemia Group
2010
UCL Australia
2003
St. Mary's Hospital
1995
Polish Academy of Sciences
1981-1990
Multinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute the removal debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large complement-opsonized materials more effectively than their unfused M2 macrophage precursors. MGC expression complement receptor 4 (CR4) was increased, but it functioned primarily as an adhesion integrin. contrast, although CR3 not became functionally activated during located on...
Objectives: In a long-term randomised coronary artery bypass grafting (CABG) study, the patency rate using new 'no touch' (NT) vein-graft preparation technique was superior to conventional (C) technique. This cineangiographic and intravascular ultrasound (IVUS) substudy examined possible mechanisms. Methods: A total of 45 patients (118 grafts) in NT group 46 (112 C had patent grafts at short-term follow-up after 18 months. Thirty-seven (91 37 (77 8.5 years, were evaluated on scale from 0...
Phosphoinositide (PI) lipids are intracellular membrane signaling intermediates and effectors produced by localized PI kinase phosphatase activities. Although many roles of kinases have been identified in cultured cell lines, transgenic animal studies unexpected insight into the vivo functions specific 3- 5-kinases, but no mammalian 4-kinase (PI4K) knockout has previously reported. Prior using cells implicated PI4K2alpha isozyme diverse functions, including receptor signaling, ion channel...
Coronary artery bypass graft surgery (CABG) is routinely used to restore blood flow diseased cardiac muscle due coronary disease. The patency of conventional grafts decreases with time, which thrombosis and formation neointima. A primary cause failure the mechanical damage inflicted during harvesting, including removal surrounding tissue accompanied by high pressure saline distension overcome vasospasm (both causing considerable trauma). aim this study was compare ultrastructural features...
No-touch (NT) saphenous vein (SV) grafts are superior to SVs harvested by the conventional technique (CT), with a patency comparable internal thoracic artery (ITA). Preservation of vasa vasorum is implicated in success NT harvesting. We compared and endothelial nitric oxide synthase (eNOS) SV ITA radial (RA) grafts. Skeletonized (SSV) was also analyzed. The had higher number larger ( P = .0001) RA .0004) that correlated eNOS protein. Activity SSV significantly lower than 004). Since high...
Endothelin-1 (ET-1) is an endothelium-derived peptide that also possesses potent mitogenic activity. There a suggestion the ET-1 neuropeptide, based mainly on its histological identification in both central and peripheral nervous system number of species, including man. A neuropeptide role for supported by studies showing variety effects caused following administration into different regions brain application to nerves. In addition there are proposing implicated neural circuits where...
Erectile dysfunction (ED) commonly occurs in approximately 15% of men over 70 years old. A number causes this condition are recognised with the major mechanism ED being an impaired relaxation corpus cavernosum (CC) smooth muscle and resulting reduction penile blood flow. There reports that is associated a local levels endothelium-derived nitric oxide (NO) most studies focussing on potential role endothelial synthase (eNOS) erectile process. Since there neurogenic component we have studied...
Freshly isolated thoracic aortic endothelial cells from 4- and 12-month-old male rabbits were exposed to two periods of increased flow rate the levels ATP, endothelin (ET) arginine vasopressin (AVP) released into perfusate measured. The rapid, significant release ATP ET with was not seen when 4-month-old same conditions. Increased did stimulate AVP either age group. Basal low also differed in compared rabbits; thus 4-month preparations basal greater, that smaller, while unchanged relative...