A5077915447- Cardiac and Coronary Surgery Techniques
- Nitric Oxide and Endothelin Effects
- Cardiac Valve Diseases and Treatments
- Receptor Mechanisms and Signaling
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renin-Angiotensin System Studies
- Neuroscience of respiration and sleep
- Electrospun Nanofibers in Biomedical Applications
- Pharmacological Receptor Mechanisms and Effects
- Pulmonary Hypertension Research and Treatments
- Hormonal and reproductive studies
- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Cardiac Imaging and Diagnostics
- Angiogenesis and VEGF in Cancer
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Cardiovascular Issues in Pregnancy
The Royal Free Hospital
2015-2025
University College London
2015-2025
University Hospital Centre Zagreb
2022
University of Zagreb
2022
NIHR Bristol Cardiovascular Biomedical Research Unit
1998-2022
Roland Hill (United Kingdom)
1996-2018
United Nations Industrial Development Organization
2008
Royal Free London NHS Foundation Trust
1997-2002
Uppsala University Hospital
2002
Royal London Hospital
2002
The endothelins are a family of endothelium-derived peptides that possess variety functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction migration, hence contributing to matrix remodeling repair. Here, we show addition ET-1 normal lung fibroblasts induces expression proteins contribute contractile phenotype, α-smooth muscle actin (α-SMA), ezrin, moesin, paxillin. We confirm enhances the ability contract...
The endothelins are a family of endothelium-derived peptides that possess variety biological activities, including potent vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and pulmonary fibrosis. Here, we use genome-wide expression array analysis to show the addition ET-1 (100 nm, 4 h) normal lung fibroblasts directly induces matrix matrix-associated genes, profibrotic protein CCN2 (connective growth factor, or CTGF). MEK/ERK MAP kinase pathway in fibroblasts....
The signal transduction mechanisms generating pathological fibrosis are almost wholly unknown. Endothelin-1 (ET-1), which is up-regulated during tissue repair and fibrosis, induces lung fibroblasts to produce contract extracellular matrix. Lung isolated from scleroderma patients with chronic pulmonary elevated levels of ET-1, contribute the persistent fibrotic phenotype these cells. Transforming growth factor beta (TGF-beta) In this report, we show that TGF-beta ET-1 in normal a...
Leukotrienes are a class of biologically active lipids that have potent effects on the heart. To assess their role in coronary artery disease, we compared contractile responses leukotriene C4 (LTC4) and D4 (LTD4) binding activity both atherosclerotic nonatherosclerotic human arteries. We also studied expression enzymes control formation to understand how 5-lipoxygenase (5-LO) pathway is activated arteries.The capacity leukotrienes affect vessel tone influence atherosclerosis was tested organ...
The effects of intracerebroventricular (i.c.v.) and intracisternal (i.c.) administration a range doses (0.01, 0.1 1.0 nmol kg −1 ) specific μ‐ δ‐ κ‐opioid agonists on cardiovascular respiratory function plasma catecholamines have been studied in conscious rabbits. distribution receptors was localized rabbit brain by vitro autoradiography. μ‐agonist [D‐Ala 2 , MePhe 4 ‐Gly 5 ‐ol]enkephalin (DAGOL) given i.c.v. caused large rise noradrenaline adrenaline, hypertension accompanied an initial...
<i>Background/Aims:</i> The saphenous vein is commonly used for coronary artery bypass surgery but its patency poor. Vascular damage occurs during conventional surgery. However, improves when the graft harvested with minimal surgical trauma, partly due to preservation of vascular endothelial nitric oxide synthase (eNOS) and tissue sources (NO), a factor possessing both dilatory anti-proliferative properties. Apart from these grafts exhibiting an intact luminal endothelium they...
Diabetes Mellitus (DM) is a major risk factor for erectile dysfunction in both patients and animal models. The pathogenesis of this has not been fully elucidated. However, alterations the synthesis number vasoactive compounds, such as nitric oxide (NO) prostacyclin (PGI2), have reported various diabetic tissues. interaction between NO, PGI2 endothelin-1 (ET-1), powerful vasoconstrictor smooth muscle cell mitogen, thought to be important maintaining vascular tone process. We investigated...
Abstract Endothelin‐1 (ET‐1) is produced by and stimulates colorectal cancer cells. Fibroblasts produce tumour stroma required for development. We investigated whether ET‐1 stimulated processes involved in production colonic fibroblasts. Primary human fibroblasts, isolated from normal tissues adjacent to colon cancers, were cultured with or without its antagonists. Cellular proliferation, migration contraction measured. Expression of enzymes development alterations gene transcription...
Coronary artery bypass graft surgery (CABG) is routinely used to restore blood flow diseased cardiac muscle due coronary disease. The patency of conventional grafts decreases with time, which thrombosis and formation neointima. A primary cause failure the mechanical damage inflicted during harvesting, including removal surrounding tissue accompanied by high pressure saline distension overcome vasospasm (both causing considerable trauma). aim this study was compare ultrastructural features...