A5019372279- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- Nonmelanoma Skin Cancer Studies
- AI in cancer detection
- Artificial Intelligence in Healthcare and Education
- Oral microbiology and periodontitis research
- Vasculitis and related conditions
- Drug-Induced Adverse Reactions
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Vitamin K Research Studies
- Reproductive System and Pregnancy
- Brain Metastases and Treatment
- Ovarian cancer diagnosis and treatment
- Multiple Myeloma Research and Treatments
- Food and Agricultural Sciences
- Fatty Acid Research and Health
- Tumors and Oncological Cases
- RNA regulation and disease
- HIV/AIDS drug development and treatment
Bursa Uludağ Üni̇versi̇tesi̇
2021-2025
Istanbul University
2011-2023
GATA Haydarpaşa Eğitim Hastanesi
2003
ABSTRACT Background Colorectal cancer (CRC) ranks as the third most prevalent worldwide. Recent studies suggest promising potential of microRNAs (miRNA) in predicting status circulating tumor cells (CTC), and their combined analyses could pave way for significant advancements assessing risk metastatic cancer. Here, we investigate miRNA signatures associated with CTC CRC (mCRC). Methods The mCRC patients was assessed using AdnaTest ColonCancer technology, which detects an immunomagnetic...
Epithelial ovarian cancer (EOC) is the type of OC with highest mortality rate. Due to asymptomatic nature disease and few available diagnostic tests, it mostly diagnosed at advanced stage. Therefore, present study aimed discover predictive and/or early novel circulating microRNAs (miRNAs or miRs) for EOC. Firstly, microarray analysis miRNA expression levels was performed on 32 samples female individuals: Eight plasma from patients pathologically confirmed EOC (mean age, 45 (30-54) years),...
The purpose of this study was to identify specific circulating microRNAs (miRNAs) and investigate expression level their target genes for evaluation pathogenesis epithelial ovarian cancer (EOC).In study, we have studied on EOC patients' serum whole blood, healthy control (HC) serum, blood samples. Sixteen samples were collected compare miRNA analysis through microarray. According microarray results, one the dysregulated in hsa-let-7d-3p, validated by RT-qPCR discriminate two groups....
Recent studies have focused on the early detection of ovarian cancer (OC) using tumor materials by liquid biopsy. The mechanisms microRNAs (miRNAs) to impact OC and signaling pathways are still unknown. This study aims reliably perform functional analysis previously validated circulating miRNAs' target genes pathfindR. Also, overall survival pathological stage analyses were evaluated with which common in Cancer Genome Atlas GTEx datasets. Our previous three downregulated miRNAs...
Artificial intelligence provides modelling on machines by simulating the human brain using learning and decision-making abilities. Early diagnosis is highly effective in reducing mortality cancer. This study aimed to combine cancer-associated risk factors including genetic variations design an artificial system for assessment. Data from a total of 268 breast cancer patients have been analysed 16 different variant classifications. In total, 61 BRCA1, 128 BRCA2 11 both BRCA1 genes associated...
Aim: Dietary miRNAs in foods were recently suggested to be absorbed into the human circulation and engage gene regulation. This started a debate on their possible impacts diseases which need further investigation. In this study, we aimed identify putative functions implications of selected Xeno-miRs by using bioinformatic tools. Methods: Seventy-five absorbable Xeno-miR candidates from literature narrowed down list that share sequence homologies with miRNAs. Sixteen distinct animal species...
ABSTRACT The cutaneous squamous cell carcinoma is a malignant epithelial tumour that usually arises from an underlying precursor skin lesion. We report the case of 65‐year‐old woman with multiple de novo carcinomas in unusual presentation.
Objective: Breast cancer (BC) is the most common type in women and may be inherited, mostly an autosomal dominant pattern.The clinical diagnosis of BC relies on published diagnostic criteria, analysis two genes, BRCA1 BRCA2, which are strongly associated with BC, included these criteria.The aim this study was to compare index cases non-BC individuals terms genotype features investigate genotype/demographic information association. Materials Methods:Mutational analyses for BRCA1/BRCA2 genes...
Personalized medicine is a relatively new and interesting concept in the medical healthcare industries. New approaches current research have supported search for biomarkers, based on genomic, epigenomic proteomic profile of individuals, using technological tools. This perspective involves potential to determine optimal interventions provide benefit-risk balance treatment, whilst it also takes patient's personal situation into consideration. Translational genomics, subfield personalized...
Specialized pro-resolving lipid mediators (SPMs), derived from polyunsaturated fatty acids are important in the resolution of inflammation. Recent studies have focused on effects SPMs cardiovascular health and diseases. However, little is known about effect human vascular tone. Therefore, this study it aimed to investigate various including resolvin D- E-series, maresin-1 (MaR1) lipoxin-A4 (LxA4) tone isolated saphenous vein (SV) preparations under inflammatory conditions. In addition, we...
Aim: Ovarian cancer (OC) is the most lethal gynecologic malignancy and frequently diagnosed at an advanced stage because of inadequate number biomarkers. Therefore, identification OC specific biological markers a vital step for diagnosis treatment response. Our goal to examine functional gene sets which are possibly ovarian their expression profiles in patients. We also aim determine potential genes therapeutic targets Method: The levels seven (FOS, FOSL2, JUN, MMP-2, MMP-9, TIMP-2, VEGFA)...
Kansere neden olan genlerdeki çoklu değişiklikler normal hücre özelliklerini zamanla sürekli proliferatif sinyal iletimi, ölümüne direnç, oksijen ve besin temini için damar büyümesini uyarma (anjiyogenez), aktif invazyon metastaz ile karakterize edilen kanser fenotipine dönüştürür.Bu fenotipik değişikliklerin
Abstract BACKGROUND Breast Cancer is the most common cancer type in women, second among all cancers, and inherited with autosomal dominant pattern. The clinical diagnosis of BC relies on published diagnostic criteria, two genes have been identified as main causative for breast which are BRCA1 BRCA2 . OBJECTIVE We aimed to compare index cases features describe genotype/demographic information association cancer. METHODS performed mutational analyses 2475 individuals from collobrative centers...