A5033236366- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Genetic and Kidney Cyst Diseases
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- RNA Research and Splicing
- Advanced Chemical Sensor Technologies
- Genomics and Rare Diseases
- Diet and metabolism studies
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- COVID-19 diagnosis using AI
- Kruppel-like factors research
- BRCA gene mutations in cancer
- Gout, Hyperuricemia, Uric Acid
- Respiratory viral infections research
- Wnt/β-catenin signaling in development and cancer
Near East University
2018-2025
National Institute of Biology
2023
University of Perugia
2023
Bursa Uludağ Üni̇versi̇tesi̇
2021-2023
Erciyes University
2021
Medical Genetics Center
2021
University of Nicosia
2020
West Nile Virus (WNV) infection represents a major global public health challenge. Even though most of the patients are asymptomatic, some cases progress to critical condition which may be fatal. Diagnosis traditionally relies on serological methods, but their limitations, including cross‐reactivity, highlight need for alternative approaches. Here, we present development and validation novel RT‐qPCR assay precise rapid detection WNV RNA in urine, emerging as promising specimen due its...
Background: Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the PAH gene, resulting deficient phenylalanine hydroxylase (PAH) enzyme activity and neurotoxic accumulation. Untreated PKU results progressive neurodegeneration severe intellectual disability. Neonatal screening has evolved from Guthrie test to advanced techniques like HPLC, tandem mass spectrometry, next‐generation sequencing (NGS) for molecular confirmation. This study aimed develop a...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current pandemics. This virus attacks cells by binding to transmembrane angiotensin I converting enzyme 2. In this study, we experimented a food supplement containing alpha-cyclodextrin and hydroxytyrosol improvement of defenses against SARS-CoV-2. Hydroxytyrosol has anti-viral properties able reduce serum lipids in mice. α-cyclodextrin ability deplete sphingolipids phospholipids from cellular membranes. The...
Heterogeneity in symptoms associated with COVID-19 infected patients remains unclear. ACE2 and TMPRSS2 gene variants are considered possible risk factors for COVID-19. In this study, a retrospective comparative genome analysis of the from 946 whole-exome sequencing data was conducted. Allele frequencies all were calculated filtered to remove allele lower than 0.003 prioritize functional coding variants. The majority detected intronic, only two three nonsynonymous analyzed cohort. main that...
Summary Polycystic ovarian syndrome (PCOS) is a chronic hormonal turmoil that demonstrated in 2.2−27% of women pre-menopausal age. This disease complex multigenic disorder results from the interaction between excess androgen expression, genetic susceptibility and environmental influences. PCOS associated with 40% female infertility endometrial cancer. The WNT/β-catenin signalling transduction pathway regulates aspects cell proliferation, migration fate determination tissue along early...
Intellectual and developmental disabilities result from abnormal nervous system development. Over a 1,000 genes have been associated with intellectual disabilities, driving continued efforts toward dissecting variant functionality to enhance our understanding of the disease mechanism. This report identified two novel variants in CC2D1A cohort four patients unrelated families. We used multiple model systems for functional analysis, including Xenopus , Drosophila patient-derived fibroblasts....
Thrombotic and microangiopathic effects have been reported in COVID-19 patients. This study examined the contribution of hereditary thrombophilia factors Prothrombin (FII) Factor V Leiden (FVL) genotypes to severity disease development thrombosis. investigated FII FVL alleles a cohort 9508 patients (2606 male 6902 female) with thrombophilia. It was observed that 930 these had infected by SARS-CoV-2 causing COVID-19. The demographic characteristics their medical history were recorded....
Abstract A coronavirus disease 2019 (COVID-19) disease, caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), has created significant concern since December worldwide. The virus is known to be highly transmissible. Heterogenic clinical features even vary more among SARS-CoV-2 variants from asymptomatic forms symptoms. Previous studies revealed an association between COVID-19 and vitamin D deficiency resulting its low levels in patients. To our knowledge, there no scientific...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new responsible for the current pandemic of disease 2019 (COVID-19). This virus attacks cells airway epithelium by binding transmembrane angiotensin-converting enzyme (ACE2). Hydroxytyrosol has anti-viral properties. Alpha-cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. The aim present experimental study was to evaluate efficacy α-cyclodextrin hydroxytyrosol in improving defenses against...
Abstract Data consisting of millions cases cannot still explain the immunopathogenesis mechanism between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and host cell for ongoing disease 2019 (COVID-19) pandemics. Epidemiological studies among different populations suggested impacts ABO Rh antibodies on COVID-19 susceptibility. Thus, blood group SARS-CoV-2 paradox remain unclear. Therefore, present retrospective case–control study aimed to investigate possible...
Joubert syndrome (OMIM #213300) is a rare neurodevelopmental disease characterized by abnormal breathing patterns, intellectual impairment, ocular findings, renal cysts, and hepatic fibrosis. It classified as ciliopathy disease, where cilia function or structure in various organs are affected. Here, we report 17-year-old male whose main clinical findings oculomotor apraxia truncal ataxia. Magnetic resonance imaging revealed the characteristic molar tooth sign of syndrome. He also has...
Artificial intelligence provides modelling on machines by simulating the human brain using learning and decision-making abilities. Early diagnosis is highly effective in reducing mortality cancer. This study aimed to combine cancer-associated risk factors including genetic variations design an artificial system for assessment. Data from a total of 268 breast cancer patients have been analysed 16 different variant classifications. In total, 61 BRCA1, 128 BRCA2 11 both BRCA1 genes associated...
Abstract Objectives Fructose-1,6-bisphosphatase deficiency (FBPase deficiency, OMIM 229700) is an early-onset rare genetic disorder caused by mutations in the FBP1 gene. Case presentation Our patient was 17-years-old when she diagnosed with disease. Initial sequencing analysis Ion Torrent technology failed to detect gross deletion that covered complete exon 2 (c.-24-26_170 + 5192del) of gene and delay diagnosis. Deletion then detected performed Illumina MiSeq platform. Conclusions This case...
Investigation of cytochrome p450 CYP1A2, CYP2D6, CYP2E1 and CYP3A4 gene expressions polymorphisms in
Abstract IntroductionA COVID-19 disease, caused by the SARS-CoV-2, created significant concern since December 2019 worldwide. The virus is known to be highly transmissible. Heterogenic clinical features even vary more among SARS-CoV-2 variants from asymptomatic forms severe symptoms. Previous studies revealed an association between and vitamin D deficiency resulting its low levels in patients. To our knowledge, there no scientific investigation that evaluates direct of VDR gene markers...
Variants (Alfa, Gamma, Beta, and Delta) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are circulating worldwide. These variants concerns share some common mutations but they also have distinguishing mutations. affect transmissibility virus cause evasion from neutralizing antibodies. Monitoring identification is great importance for public health. In this study, an in-house SARS-CoV-2 reverse transcription quantitative polymerase chain reaction (RT-qPCR) kit was designed to...