A5004665149- Mitochondrial Function and Pathology
- Congenital heart defects research
- Spondyloarthritis Studies and Treatments
- Genetics and Neurodevelopmental Disorders
- Connective tissue disorders research
- Retinal Development and Disorders
- Fibroblast Growth Factor Research
- CRISPR and Genetic Engineering
- Metabolism and Genetic Disorders
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurological diseases and metabolism
- Skin and Cellular Biology Research
- Bone health and osteoporosis research
- Platelet Disorders and Treatments
- RNA regulation and disease
- Cystic Fibrosis Research Advances
- Tissue Engineering and Regenerative Medicine
- Redox biology and oxidative stress
- Sepsis Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Temporomandibular Joint Disorders
- Hemophilia Treatment and Research
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
Konya Eğitim ve Araştırma Hastanesi
2022-2024
Sağlık Bilimleri Üniversitesi
2023
Konya Food and Agriculture University
2023
Necmettin Erbakan University
2021
Zübeyde Hanim Maternity Hospital
2019
Maternity and Children's Hospital
2018
Behçet's Disease (BD) may impair bone remodeling, increasing osteoporosis risk. This study evaluates mandibular trabecular fractal dimension (FD), cortical index (MCI), and temporomandibular joint (TMJ) degeneration in BD patients versus healthy controls. A total of 106 panoramic radiographs, comprising 53 from individuals, were examined. Fractal analysis was performed using ImageJ software, selecting 50 × pixel regions interest (ROIs) the gonial, interdental, condylar areas. Degenerative...
Thrombotic and microangiopathic effects have been reported in COVID-19 patients. This study examined the contribution of hereditary thrombophilia factors Prothrombin (FII) Factor V Leiden (FVL) genotypes to severity disease development thrombosis. investigated FII FVL alleles a cohort 9508 patients (2606 male 6902 female) with thrombophilia. It was observed that 930 these had infected by SARS-CoV-2 causing COVID-19. The demographic characteristics their medical history were recorded....
aDepartment of Medical Genetics, Dr Ali Kemal Belviranli Maternity and Pediatric Hospital, Konya bDepartment Firat University School Medicine, Elazig cDepartment Intergen Genetic Center, Ankara, Turkey Correspondence to Muserref Basdemirci, MD, Department 42285, Tel: +90 506 325 0306; fax: 332 237 6025; e-mail: [email protected]
Basdemirci, Muserref; Zamani, Ayse G.; Sener, Sevgi; Tassoker, Melek; Cetmili, Hayriye; Adil; Aydogdu, Demet; Ali; Yildirim, Mahmut S. Author Information
Abstract This study aimed to examine the difference between fractal dimension (FD) values of mandibular trabecular bone and panoramic index (PMI), cortical (MCI) thickness (MCW) patients with ankylosing spondylitis (AS) healthy control group. A total 184 individuals (92 cases, 92 controls), were examined in our study. PMI, MCI, MCW calculated on images all individuals. For FD values, region interest (ROI) was selected size 100 × pixels from right-left gonial interdental regions 50 condylar...
Objective: The FDXR gene encodesferredoxin reductase, which is a mitochondrial membrane protein and plays role in Fe-S cluster synthesis. Loss of function this causes intracellular iron accumulation, leading to dysfunction, especially nervous system cells. To date, 46 patients with biallelic variants have been reported. While optic atrophy was common finding most the patients, it found that many neurological findings were also accompanied. Method: Two siblings from an unrelated Turkish...
Aims: Myelodisplastic syndromes (MDS) are hematological disorders originating from clonal damage and characterized by inefficient bone marrow activity. The existence of mutations has been shown to play a significant role in risk, treatment response, turnover acute myeloid leukemia, prognosis, overall survival. Next-generation sequencing (NGS) is technique that detects gene the subject studies for detecting MDS-related mutations. Methods: We conducted study on 33 MDS patients during period...
Background: Mutations in the RAS genes, HRAS, KRAS , and NRAS are most common modifications many types of human tumors found approximately 30% all cancers. These mutations usually codons 12, 13, or 61. Methods: The aim this study is to evaluate 59, 117, 146 genes addition 12,13, 61 gene lung cancer tissue specimens obtained with bronchoscopy. mutation analyses pyrosequencing were performed on DNA isolated from formalin-fixed paraffin-embedded (FFPE) samples 64 patients histopathologically...
Inherited retinal dystrophies (IRDs) associated with more than 300 genes are a clinically and genetically heterogeneous group of diseases. This study aimed to identify causative gene variants molecular basis Turkish patients IRD.
Kindler syndrome (KS) was first described by Theresa in 1954, and since then > 60 pathogenic variants have been identified the FERMT1 gene for KS. Most associated with KS are null variants. We present case of a child poikilodermic changes on forehead cheeks, who found to homozygous c.1676G>A mutation. To our knowledge, this is report mutation family
Hepatocellular carcinoma (HCC) is one of the important causes mortality due to malignancy. Toll-like receptors (TLRs) are very in liver pathophysiology terms their roles innate immune system, such as regulation inflammation, wound healing, stimulation adaptive responses, promotion epithelial regeneration, and carcinogenesis. In this study, we planned examine role TLR1 (rs4833095, rs5743551) nucleotide-binding oligomerization domain (NOD2) (rs2066844, rs2066845, rs2066847) polymorphisms...