A5021004341- Genetics and Physical Performance
- Luminescence and Fluorescent Materials
- Muscle metabolism and nutrition
- Cardiovascular Effects of Exercise
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Porphyrin and Phthalocyanine Chemistry
- Crystallization and Solubility Studies
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Cancer-related Molecular Pathways
- Sports Performance and Training
- Photodynamic Therapy Research Studies
- Genomics and Chromatin Dynamics
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Coffee research and impacts
- Muscle Physiology and Disorders
- Pregnancy and preeclampsia studies
- Ferroptosis and cancer prognosis
- Reproductive System and Pregnancy
- PARP inhibition in cancer therapy
- Synthesis and Characterization of Heterocyclic Compounds
- Nanopore and Nanochannel Transport Studies
Sağlık Bilimleri Üniversitesi
2024-2025
University of Health Science
2024-2025
Near East University
2023-2024
Mersin Üniversitesi
2023
Gazi University
2020-2022
Gazi Hastanesi
2022
Middle East Technical University
2015-2021
The aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes compare allelic frequencies between sprint/power endurance controls using a whole-exome sequencing (WES) approach, followed by replication studies independent cohorts. discovery phase involved 60 elite (31 29 endurance) 20 ethnically matched controls. 1132 individuals (115 Russian sprinters, 373 (of which 75 were VO2max measurements), 209 controls, 148 287 Finnish...
Background: Exercise addiction, marked by an inability to control exercise and associated with distress that clinically impairs daily activities, is a significant but underrecognized issue in physical activity health. While its physiological, psychological, behavioral aspects have been studied, the genetic basis of addiction remains poorly understood, requiring further investigation. The present study conducted genome-wide association among elite Turkish wrestlers. Methods: sample comprised...
A systematic series of fluorescence chemosensors based on cyclotriphosphazene derivatives were designed, synthesized, and evaluated for their sensing behaviors toward metal ions.
The α-actinin-3 (ACTN3) gene rs1815739 (C/T, R577X) polymorphism is a variant frequently associated with athletic performance among different populations. However, there limited research on the impact of this athlete status and physical in basketball players. Therefore, aim study was twofold: (1) to determine association ACTN3 changes response six weeks training elite players using 30 m sprint Yo-Yo Intermittent Recovery Test Level 2 (IR 2) tests, (2) compare genotype allelic frequencies...
In this study, a novel photosensitizer having two perylenediimide units and phenanthroline ruthenium(<sc>ii</sc>) coordination moiety (<bold>Ru-BP)</bold>has been developed for photodynamic therapy (PDT) of cancer cells.
The present study aimed to examine the vitamin D receptor (VDR), rs2228570 polymorphism, and its effect on elite athletes’ performance. A total of 60 athletes (31 sprint/power 29 endurance) 20 control/ physically inactive, aged 18–35, voluntarily participated in study. International Association Athletics Federations (IAAF) score scale was used determine performance levels personal best (PB). Whole exome sequencing (WES) performed by genomic DNA isolated from peripheral blood participants....
Molecular design and synthesis of cyclotriphosphazene-BODIPY-based PSs based on a halogen atom-enhanced ISC process were carried out their photophysical behaviors, ROS production abilities finally in vitro PDT potentials investigated.
The aim of the current study was to determine whether rs17602729 polymorphism in Adenosine monophosphate deaminase-1 (AMPD1) gene is related elite athlete performance. A total 60 athletes, aged 18–35, who were split into two groups—31 sprinters/power athletes and 29 endurance athletes—as well as 20 control/sedentary individuals, willingly participated study. performance levels based on their personal bests (PBs), rated using World Athletics (WA) score. Whole exome sequencing (WES) performed...
Abstract Background This study aimed to achieve a dual objective: compare the frequencies of CYP1A2 rs762551 genotypes between team sport athletes and control group, determine association polymorphism changes in physical performance after six-week training program among elite basketball players. Methods The encompassed an analysis 504 individuals, comprising 320 184 controls. For Turkish cohort, DNA was isolated using buccal swab method, genotyping conducted KASP technique. Performance...
Abstract Insertions and deletions (indels) are the second most common type of variation in human genome. However, limited data on their associations with exercise‐related phenotypes have been documented. The aim present study was to examine association between 18,370 indel variants power athlete status, followed by additional studies 357,246 individuals. In discovery phase, D allele MDM4 gene rs35493922 I/D polymorphism over‐represented athletes compared control subjects ( P = 7.8 × 10 −9 )...
Estrogen receptor α (ERα), as a ligand-dependent transcription factor, mediates 17β-estradiol (E2) effects. ERα is modular protein containing DNA binding domain (DBD) and activation domains (AD) located at the amino- carboxyl-termini. The interaction of E2-activated dimer with estrogen response elements (EREs) genes constitutes initial step in ERE-dependent signaling pathway necessary for alterations cellular features. We previously constructed monomeric activators, or monotransactivators,...
Abstract Lipoxygenases (LOXs) are a family of enzymes that can oxygenate polyunsaturated fatty acids. As member the family, 15‐lipoxygenase‐1 (15‐LOX‐1) specifically metabolizes arachidonic acid and linoleic acid. 15‐LOX‐1 affect physiological pathophysiological events via regulation protein–lipid interactome, alterations in intracellular redox state production lipid metabolites involved induction resolution inflammation. Although several studies have shown has an antitumorigenic role many...
Abstract Novel 17α‐Etinylestradiol‐substituted 4,4‐difluoro‐4‐borata‐3a,4a‐diaza‐s‐indacene (BODIPY) dyes were prepared as fluorescent imaging probes. The identities of newly synthesized fully characterized by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry, and 1 H 13 C nuclear magnetic resonance (NMR) spectroscopy. photophysical properties (molar extinction coefficient, fluorescence lifetime quantum yield) the compounds investigated means absorption...
Introduction Exercise addiction is a phenomenon being able to affecting the athletic performance. The gene, ANKK1 and polymorphism NM_178510.2:c.2137G &gt; A (rs1800497) has been linked exercise addiction. However, further studies on diverse populations sport branches are needed totally explore possible association of this with Thus, present study aims decipher any relations rs1800497 performance/personal best (PB) experience elite athletes. Methods Sixty volunteer athletes (31...
Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile.
In this study, a set of bio-compatible and NIR emissive BODIPY-subphthalocyanine dyads (<bold>SP–DBD1–3</bold>) that contain amphiphilic triethyleneglycol units supporting partial water solubility red absorbing BODIPY monomers (<bold>DBD1–3</bold>) were prepared.