A5080709184- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Bioactive Compounds and Antitumor Agents
- Luminescence and Fluorescent Materials
- Inorganic and Organometallic Chemistry
- Photochromic and Fluorescence Chemistry
- Axial and Atropisomeric Chirality Synthesis
- Multicomponent Synthesis of Heterocycles
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Synthesis of Indole Derivatives
- Free Radicals and Antioxidants
- Molecular Junctions and Nanostructures
- Catalytic Cross-Coupling Reactions
- Graph theory and applications
- Advanced Physical and Chemical Molecular Interactions
Gebze Technical University
2018-2024
Namık Kemal University
2023
Australian National University
2016
The [n]dendralenes are a family of acyclic hydrocarbons which, by virtue their ability to rapidly generate structural complexity, have attracted significant recent synthetic attention. [3]Dendralene through [8]dendralene been previously prepared but no higher member the has reported date. Here, we describe first chemical syntheses "higher" dendralenes, [9]dendralene [12]dendralene. We also report detailed investigation into spectroscopic properties and reactivity complete fundamental...
The first synthesis of all five possible monomethylated [4]dendralenes has been achieved via two distinct synthetic strategies. Diels-Alder chemistry these new dendralenes (as multidienes) with an electron poor dienophile, N-methylmaleimide (NMM), studied. Thus, simply upon mixing the dendralene and excess dienophile at ambient temperature in a common solvent, sequences cycloadditions result rapid generation complex multicyclic products. Distinct product distributions are obtained...
Novel peripherally and non-peripherally 3-methylindole-substituted zinc phthalocyanine derivatives were synthesized as photosensitizers for photodynamic therapy in cancer treatment. The photophysical, photochemical photobiological properties of targeted phthalocyanines also investigated. For this purpose, the fluorescence singlet oxygen quantum yields, lifetime values final compounds determined DMF solutions. phototoxicity cytotoxicity complexes tested against invasive human breast cell line...
Abstract Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, range indole‐7‐carbohydrazides successfully synthesized starting from readily available 3‐phenyl 2,3‐diphenyl 4,6‐dimethoxyindoles. The novel compounds were confirmed by utilizing 1 H NMR, 13 C FT‐IR, high‐resolution mass spectrometry, single crystal X‐ ray diffraction techniques. addition, showed promising antioxidant results...
A number of novel pyrrolo[3,2-c]carbazole-2-carbohydrazides 5a–d was prepared from readily available 6-methyl-1,6-dihydropyrrolo[3,2-c]carbazole-2-carboxylate 3 and underwent cyclodehydration to produce the corresponding 2-(6-ethyl-1,6-dihydropyrrolo[3,2-c]carbazol-2-yl)-1,3,4-oxadiazoles 6a–d with p-toluenesulfonyl chloride (p-TsCl) N,N-diisopropylethylamine (DIPEA) as dehydrative reagents. The structures targeted compounds were confirmed through 1H NMR, 13C IR, mass spectrometry single...
Hakan Kandemira, Mehmet F. Saglamb & Ibrahim Sengulb*a Department of Chemistry, Faculty Art and Science, Namık Kemal University, Tekirdag, Turkeyb Gebze Technical Gebze, Kocaeli, Turkey
Tetra substituted peripheral and non-peripheral Zn(II) phthalocyanines were successfully synthesized employing 4-(bis(3-methyl-1H-indol-2-yl)methyl)phenol as a starting material. The structure of these compounds was confirmed using 1 H NMR, [Formula: see text]C infrared (IR), UV-vis, MALDI-TOF spectral data. photophysical (fluorescence quantum yields lifetimes) photochemical (singlet oxygen generation) properties all investigated in order to determine the potential for application...
Phthalonitrile-3-yl (PN3) substituted indole derivative 1 was structurally characterized. The compound crystallized in a monoclinic system and characterized as follows: P21/c, = 23.232(5), b 7.4413(14), c 15.361(4)Å, β 106.818(5)°, Z 8, V 2542.0(10)Å3. crystal structure solved by direct methods refined full-matrix least-squares on F2 to the final values of R1 0.0660 wR2 0.1610. has two crystallographically independent molecules asymmetric unit. dihedral angle between PN3 is 42.17(8)°....