A5043874487- Liver Disease Diagnosis and Treatment
- Paraoxonase enzyme and polymorphisms
- Inflammasome and immune disorders
- Hepatitis C virus research
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Microscopic Colitis
- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Gastrointestinal motility and disorders
- Turkish Literature and Culture
- Clinical Nutrition and Gastroenterology
- Gastric Cancer Management and Outcomes
- Alcohol Consumption and Health Effects
- Hormonal and reproductive studies
- Peptidase Inhibition and Analysis
- Intestinal and Peritoneal Adhesions
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Immune Response and Inflammation
Erciyes University
2011-2024
University Gastroenterology
2007-2017
Kayseri Eğitim ve Araştırma Hastanesi
2005-2017
Weatherford College
2010
The present study was designed to investigate the relationship between serum levels of oxidant-antioxidant system (malondialdehyde (MDA) level, Paraoxonase (PON1) activity, nitric oxide (NO) level and superoxide dismutase (SOD) activity) thyroid hormone status in hypothyroidism pre posttreatment. group comprised 33 patients with primary hypothyoidism. 18 these were reevaluated after euthyroid state i.e. at least 6 months thyroxine replacement. compared 26 normal healthy controls. Serum MDA...
AIM:To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease (NAFLD). METHODS:Twenty patients with histologically proven NAFLD and 20 controls were included.All cases scored using the activity score.The relative expressions of miR-197, miR-146b, miR-10b, miR-181d, miR-34a, miR-122, miR-99a miR-29a analyzed real-time polymerase chain reaction. RESULTS:Serum levels miR-99a, miR-197 miR-146b significantly lower in biopsy-proven than healthy controls.Serum miR-10b...
We aimed to determine the importance of neutrophil activation and source oxidative stress in pathogenesis rheumatoid arthritis (RA) by quantification advanced oxidation protein products (AOPP) total thiol levels as markers damage, malondialdehyde (MDA) a marker lipid peroxidation myeloperoxidase (MPO) activity patients with RA. Fifty-seven were included study sub-grouped according disease (active, n = 31; inactive, 26) compared healthy controls (n 25). Serum MPO activity, AOPP, MDA, measured...
Our objective was to investigate antioxidant paraoxonase 1 (PON1) activity together with malondialdehyde (MDA) levels evaluate oxidative stress in patients age-related macular degeneration (AMD), an important cause of blindness the elderly population. Serum PON1 and MDA were analyzed 37 AMD compared 29 healthy controls using a spectrophotometric method. significantly higher patient group (2.76 ± 1.28 nmol/ml) than (1.00 0.36 nmol/ml; p < 0.001), whereas lower (132.27 63.39 U/l) (312.13...
The etiology and pathogenesis of chronic inflammatory bowel diseases are still poorly understood. Oxidative stress takes place in the ulcerative colitis (UC) advanced oxidation protein products (AOPP) accepted as a novel marker oxidative stress. There no data concerning whether AOPP may be used simple serum to assess disease activity, predict severity course UC.In this study, we determine importance neutrophil activation role UC, by quantification total thiol levels markers damage,...
In this study we aim to evaluate the relationship of advanced oxidation protein products (AOPP), total thiol, antioxidant status (TAS), oxidant (TOS) levels and oxidative stress index (OSI) in patients with nonalcoholic steatohepatitis (NASH).A 28 NASH 19 age-and-gender-matched healthy subjects were enrolled as control group. Plasma AOPP thiol determined by spectrophotometric methods. TAS TOS measured using commercially available kits OSI was calculated.Plasma (256.7 vs. 125.8 μmol/L) (8.9...
This study was designed to evaluate the oxidative and antioxidative status in patients with ulcerative colitis by detecting antioxidant enzyme paraoxonase 1 activity together level of a well-known marker stress, malondialdehyde. Serum malondialdehyde levels were analysed 30 controls using spectrophotometric method; correlation analysis made between these variables. higher group (median: 2.5, range: 0.5-9.4 nmol ml(-1)) than among (median:1.1, 0.5-2.3 ml(-1); p < 0.001) whereas activities...
Interferon therapy is the cornerstone of chronic hepatitis C treatment. Side effects interferon include possible triggering or exacerbation immune diseases in consequence immunomodulatory effects. We describe unique case, which pyoderma gangrenosum and psoriasis were developed 8 weeks after pegylated alpha 2a ribavirin a 45-year-old woman. The had to be stopped on account spite biochemical response for C. evolution was favorable stopping Therefore, we propose this would suggest autoimmune...
Aim: This was a prospective study investigating the efficacy of Ankaferd Blood Stopper® (ABS), an herbal preparation, in patients with upper gastrointestinal (UGI) bleeding. Materials and methods: A total 30 (22 male, 8 female) who had UGI bleeding (with differing causes) were included study. ABS used to stop Results: Primary hemostasis achieved 26 cases. Conclusions: is effective safe agent use
Background/Aims: To determine the prevalence of muscle cramps in patients with liver cirrhosis and to identify factors associated their development, especially serum zinc. Method: One hundred cirrhotic 85 healthy subjects were enrolled into study. True cramp was defined as at least 1 painful leg either occurring rest or strong enough waken a patient from sleep, once week persisting for period greater than year. Creatinine, calcium, magnesium, sodium, potassium, zinc, glucose, alanine...
Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease that increasingly being associated with cardiovascular disease. Ursodeoxycholic acid (UDCA) may have antioxidant and anti-inflammatory activities, reduce injury in NASH. To date, no studies assessed the efficacy of UDCA carotid intima media thickness (CIMT), serum lipids, apolipoprotein A1 (apo A), B B), B/A1 B/A1) ratios patients NASH.In this prospective study, 30 biopsy-proven NASH 25 healthy adults as control group were...
Metabolic bone disease is common in patients with chronic liver disease. Comparative studies on the efficacies of antiosteoporotic agents hepatic osteodystrophy have not been conducted yet. The aim this study was to evaluate safety and efficacy different therapeutic regimens osteodystrophy.Eighty-one (mean age 48.9 ± 10 years; 50 cases viral hepatitis 31 cirrhosis) were enrolled study. Treatment groups consisted 61 who had reduced T scores at least one region, selected randomly treated for 1...
In Europe, health-care policies are determined at a national level and differ between countries. This analysis from prospective, longitudinal, non-interventional study aimed to describe patterns in the clinical monitoring treatment of chronic hepatitis B (CHB) five European countries.Country-specific cohorts adult patients with compensated CHB managed clinics Germany, France, Poland, Romania Turkey were followed for up 2 years March 2008 December 2010.A total 1,267 included. Baseline age...
The goal of this study is to establish whether 5 days ceftriaxone treatment was sufficient cure culture-negative neutrocytic ascites in cirrhotic patients. We studied 50 patients with ascites. All were treated ceftriaxone, 1.0 g IV, twice a day for days. A control paracentesis performed 48 hours after starting the therapy assess response treatment. total 17 demographic, clinical, and laboratory variables recorded all cases on diagnosis CNNA. mean age 57.7 +/- 13.2 years. Thirty-two males 18...
Familial Mediterranean fever (FMF) is one of the most serious inherited inflammatory disorders among Jewish, Armenian, Turkish and Arab populations. The imbalance between pro- anti-inflammatory cytokines may play a role in its etiology. We have investigated whether tumor necrosis factor-alpha (TNF-α) plasminogen activator inhibitor 1 (PAI-1) gene polymorphisms are associated with FMF evaluated relationship these genotypic manifestation FMF.We single nucleotide TNF-α promoter at positions...
Aim: To construct normal values for the tests of psychometric hepatic encephalopathy score (PHES) and evaluate prevalence minimal (MHE) among Turkish patients with liver cirrhosis. Materials Methods: One hundred eighty-five healthy subjects sixty cirrhosis without overt were included in study. All underwent tests, which include number connection test-A B (NCT-A/B), serial dotting test (DST), line drawing (LDT), digit symbol (DST) same day. The variables that affected results multiple linear...