The aim of our study was to evaluate the effect in vitro anticancer and cytotoxic activity methanolic extracts 14 medicinal plants, 8 which are endemic species Anatolia, against human HeLa cervical cancer cell line compare normal African green monkey kidney epithelial (Vero) using MTT colorimetric assay. Values for cytotoxicity measured by assay were expressed as concentration that causes 50% decrease viability (IC50, μg/mL). degree selectivity compounds can be its index (SI) value. High SI...

In this work we report the isolation and characterisation of seven flavonoids, levels total phenolics, flavonoids proanthocyanidins, antioxidant activity leaf extract Rosa agrestis Savi (Rosaceae). The results showed that R. exhibited significant antioxidative as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) (EC50 = 47.4 µg mL−1), inhibited both β-carotene bleaching deoxyribose degradation, quenched a chemically generated superoxide anion in vitro high ferrous ion chelating activity....

Crataegus (hawthorn) has long been used as a folk medicine all around the world. Most of studies with species focus on effects heart failure and cardiovascular disease. The pharmacological have attributed mainly to content flavonoids, procyanidin, aromatic acid cardiotonic amines. present study investigated blood pressure structure coronary arterial wall L-NAME-induced hypertensive rats given an aqueous leaf extract C. tanacetifolia (100 mg/kg), for 4 weeks via gavage. It was observed that...

The aim of our study was to evaluate in vitro antioxidant potential methanolic extracts (ME) 14 medicinal plants, 8 which are endemic species Anatolia. Scavenging activity tested by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and the inhibitory effect on lipid peroxidation examined ferric thiocyanate (FTC) thiobarbituric acid (TBA) methods. obtained results showed significant differences amongst plant extracts. Among samples, Crataegus microphylla C. Koch, Salvia hypargeia Fisch. & Mey.,...

Vascular dysfunction plays a key role in the pathogenesis of diabetic vascular disease. In this study, we aimed to investigate whether chronic vivo treatment Crataegus microphylla ( CM ) extract rats induced with streptozotocin (STZ, intraperitoneal, 65 mg/kg) preserves function and evaluate reduction inducible nitric oxide synthase (iNOS), proinflammatory cytokines, lipid peroxidation mediates its mechanisms action. Starting at 4 weeks diabetes, (100 was administrated for weeks. aortic...

Background: Flavonoids are natural compounds with antioxidant, anticarcinogenic, and anti-inflammatory effects.Aims: To determine the cytotoxic effects of flavonoids drug resistance related to P-gp on K562 human chronic myeloid leukemia cells.We also aimed evaluate therapeutic potential imatinib flavonoid combinations.Study Design: Cell culture study.Methods: In this study, cells were treated apigenin, luteolin, 5-desmethyl sinensetin anticancer mesylate.The effect cell proliferation was...

Rosa sempervirens L. (Rosaceae) growing wildly in Turkey is used folk medicine for various indications. Here, we report the isolation of four flavonoids and determination total phenolic flavonoid contents antimicrobial antioxidant activities extracts from R. leaves. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). The were using Folin–Ciocalteu AlCl3 methods, respectively. evaluated broth microdilution...

The antioxidant, anti-inflammatory, acetylcholinesterase (AChE) inhibitory and antimicrobial activities of extract from the Centaurea antiochia Boiss. var. praealta (Boiss. & Bal.) Wagenitz, an endemic plant species Turkey, were investigated. results indicated that inhibits FeCl3/ascorbic acid-induced phosphatidylcholine liposome oxidation, scavenges stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation radicals, reduces Fe3+ to Fe2+...

Abstract Crataegus microphylla C. Koch is one of the 17 species growing in Turkey [H.P.T. Ammon and R. Kaul (1994). Dtsch. Apoth. Ztg., 134, 2433, 2521, 2631.]. This report part a series on chemical investigations from Turkey. Nine flavonoids have been isolated leaves flowers Koch. The amounts plant were determined. Keywords: microphyllaFlavonoids Acknowledgement work was supported by Research Fund University Istanbul. Project Number 1291/050599.

We investigated the cytotoxic and apoptotic effects of a methanol extract Centaurea nerimaniae, plant endemic in Turkey, on HeLa MDA-MB-231 cells. Eight concentrations C. nerimaniae were applied to cells, measured using xCELLigence system. The TUNEL assay was used assess cell death immunohistochemistry determine active caspase-3 effective doses extract. Doses 1.42 mg/ml inhibited growth cells 3.67 dose- time-dependent manner. indexes for increased significantly compared control groups....

DERLEME GİRİŞ

Ethnobotanical and ethnomedicinal studies have become increasingly recognised as a valuable source of information on the use possible pharmacological activity many plant species. There is no study presenting traditional herbal remedies used for kidney diseases in Turkey. The purpose paper to compile Turkey with detailed usage chemical constituents. botanical names, families, local names; parts; preparation methods; administration/ dosage; problems constituents were presented by screening...

Background/Aim: We aimed to investigate the synergistic effects of apigenin and curcumin on cross-talk between apoptosis autophagic cell death, as well paraptosis in HeLa cells. Materials Methods: Cell viability was measured using MTT assay. Synergistic were Bliss independence model. qRT-PCR used study expression genes related apoptosis, cross-talk. GRP78/BiP immunostaining identify endoplasmic reticulum (ER) stress. Results: Treatment with a combination increased levels death cells 1.29-...

There are many plants used by the public in treatment of various diseases Turkey.The folk remedies prepared with these from which and how they have been reached to day-to-day transferring generations. Ethnobotanic researches traditional methods recorded it is aimed contribute drug development studies.In this study, was screening ethnobotanical researches, 221 taxa against stomachache Turkey scientific , local names, families, parts forms were compiled. According research done, families that...

Rosa species are widely distributed in Turkey.  Ethanolic extracts from flowers and leaves of R. horrida, one of the 25 species of Rosa used as a traditional Turkish medicine tonic, diuretic, expectorant, stomachic for treatment dyspepsia, diarrhea nephritis were tested in vitro for their ability to scavenge DPPH·, ABTS·+ and superoxide radicals, reduce Fe (III) (II) inhibit peroxidation phophatidylcholine liposomes induced with ascorbate/Fe order establish relashionship between antioxidant...

Turkey has many plants used by public for the treatment of various diseases.The usage these been transferred from generation to generation.Ethnobotanical studies carried out traditional methods are recorded and this information is aimed contribute development drug.In study, it reached 88 taxa that in against headache give about scientific local names, families, parts headache.in headache.KeywoRdS: Headache, medicinal plants, treatment, Turkey.pressure, presence urine head neck region,...

Turkey has many plants used by public for the treatment of various diseases.The usage these folk medicine which is prepared been transferred from generation to generation.Ethnobotanical studies carried out traditional methods are recorded and this information aimed contribute development drug.ın study, it reached 77 taxa that in against anemia give about scientific local names taxa, families, parts anemia.

ct -Investigation of the alkaloidal constituents roots Aconitum nasutum led to isolation and identification a new diterpenoid alkaloid designated as trabzonine (1 ).Three known norditerpenoid alkaloids, lappaconitine (2 ), lycoctonine (3 ) gigactonine (4 two alkaloids pseudokobusine (5 septatisine (6 were also isolated.The structures 1 5 established by detailed analyses H 13 C NMR data.The structure absolute stereochemistry was determined an X-Ray crystal determination. INTRODUCTIONEarlier...

Centaurea nerimaniae S. Kultur, an endemic species from the Turkish flora, distributed in south Anatolia (Icel Province) was investigated for its flavonoids and vitro antioxidant, anti-cholinergic, anti-inflammatory antibacterial activities.The phytochemical investigation of plant led to isolation five flavonoids, identified as cirsimaritin, hispidulin, apigenin, isokaempferide apigenin 7-O-glucoside.In addition ability inhibit AChE lipid peroxidation, induced by Fe 3+ /ascorbate system,...

There are many plants used by the public in treatment of various diseases Turkey.The folk remedies prepared with these from which and how they have been reached to day-to-day transferring generations.The traditional methods recorded ethnobotanical researches it is aimed contribute drug development studies.In this study, was screening researches, 72 taxa against rheumatic pain Turkey scientific local names, families, parts use forms were compiled.According research done, families that...

Cervical cancer is one of the frequent types seen in females. It has been suggested that natural compounds can be used effectively for treatment. Apoptosis and autophagy related cell death play important roles suppression tumorigenesis. Apigenin curcumin are products isolated from plant extracts known to have antitumoral, antibacterial antiviral effects. Varying doses apigenin were applied HeLa lines. The expression genes apoptosis and/or measured using qRT-PCR viability was MTT assay. Our...