A5037453558- Enzyme function and inhibition
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Synthesis and Catalytic Reactions
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Biological Evaluation
- Plant biochemistry and biosynthesis
- Chemical Reactions and Mechanisms
- Biochemical Analysis and Sensing Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antioxidant Activity and Oxidative Stress
- Nanomaterials for catalytic reactions
- Plant-based Medicinal Research
- melanin and skin pigmentation
- Radical Photochemical Reactions
- Botanical Research and Applications
- Synthesis of Organic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Multicomponent Synthesis of Heterocycles
- Metal complexes synthesis and properties
- Nonlinear Optical Materials Research
- Morinda citrifolia extract uses
- Catalysis and Hydrodesulfurization Studies
Sakarya University
2013-2024
Balıkesir University
2014
Karadeniz Technical University
1995-2000
University of Georgia
1998
TÜBİTAK Marmara Research Center
1998
Ankara University
1998
Istanbul University
1998
New coumaryl-thiazole derivatives with the acetamide moiety as a linker between alkyl chains and/or heterocycle nucleus were synthesized and in vitro tested acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide (6c, IC50 value of 43 nM) was best AChE inhibitor selectivity index 4151.16 over BuChE. Kinetic study inhibition revealed that 6c mixed-type inhibitor. Moreover, result H4IIE hepatoma cell toxicity assay for showed negligible...
The increasing interest on new drug discovery is constantly up to date as drugs do not increase survival adequately against cancer cases worldwide. Based the reported anticancer activity of coumarin, chalcone and urea derivatives, present investigation dealt with design synthesis coumarin derivatives bearing diversely substituted chalcone-urea moieties 5a-k. Through a structure-based molecular hybridization approach, series novel coumarin-chalcone containing moiety was synthesized screened...
New coumaryl-carboxamide derivatives with the thiourea moiety as a linker between alkyl chains and/or heterocycle nucleus were synthesized and their inhibitory activity against human carbonic anhydrase (hCA) isoforms hCA I, II, VII IX evaluated. While II not inhibited by investigated compounds, tumour-associated isoform was in high nanomolar range. 2-Oxo-N-((2-(pyrrolidin-1-yl)ethyl)carbamothioyl)-2H-chromene-3-carboxamide (e11) exhibited selective action Ki of 107.9 nM. In order to better...
New secondary benzenesulphonamide-substituted coumarylthiazole derivatives were synthesized and their inhibitory effects on purified carbonic anhydrase I II evaluated using CO2 as a substrate. The result showed that all the compounds exhibited activity both hCA with N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)naphthalene-2-sulphonamide (5f, IC50 value of 5.63 8.48 µM, against II, respectively) strongest inhibitor revealed from this study. Structure-activity relationship is related to type...
In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d]pyrimidine derivatives on purified human carbonic anhydrase I II (hCA II) were investigated by using CO 2 as a substrate. The results showed that all compounds inhibited the hCA enzyme activities. Among synthesized compounds, 7e (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. The results showed that all compounds inhibited the hCA enzyme activities. Among compounds, 6-(p-tolylthiourenyl) (6m) was found to be most active one for activity (IC50 = 13.67 μM) 6-(m-methoxyphenylurenyl) (6b) 6.54 μM). Structure–activity relationships (SARs) study that, generally, thiourea (6l--v) more than urea (6a–k). All...
In this study, 4’-(phenylurenyl/thiourenyl)chalcones (14–25) were prepared from 4’-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. vitro inhibition effects of chalcone on purified carbonic anhydrase I II investigated using the CO2 hydration method Maren. The result showed that all synthesized compounds inhibited CA isoenzymes activity. 18 19 found to be most active (IC50 = 25.41 μM 23.06 μM) for hCA I, respectively. For II, 24 is compound...
Abstract A series of novel tetrahydroquinoline derivatives containing urea moiety was synthesized and their in vitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA−I hCA‐II) were evaluated by using CO 2 hydration method. All compounds exhibited activity against both hCA I II with 1‐(4‐fluorophenyl)‐3‐(4‐(4‐p‐tolyl‐5,6,7,8‐tetrahydroquinolin‐2‐yl)phenyl)urea ( 7 k , IC 50 value 5.28 μM 5.51 μM, II, respectively) as strongest inhibitor this study. Structure‐activity...
Red beet (Beta vulgaris L.) is a rich source of phenolic content including colour pigments and have also high antioxidant capacities. The amounts their substances activities change depending on the extraction conditions (pH, time, solvent, etc.). In this work, coloured water extracts were obtained from red at different pH values (pH 4-10) for both an hour 24 hours. evaluated regarding total contents (TPC). results showed that extract in all ranged 0.55±0.02 to 2.30±0.19 mg GAE/g FW. highest...
A newly series of isatin derivatives (6a-t) containing alkyl/aryl urea groups were synthesized and their inhibitory effects on the diphenolase activity banana tyrosinase evaluated. Tyrosinase was purified from an affinity gel comprised Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The results showed that all compounds inhibited enzyme activity. Among them, 1-(2,3-dioxoindolin-5-yl)-3-(4-nitrophenyl)urea (6l) found to be most active compound (Ki = 24.96 µM). inhibition kinetics analysed by...
Charge transfer complexes (CTC) of mirtazapine with tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano- p -benzoquinone (DDQ), and tetracyanoquinodimethane (TCNQ) have been studied spectrophotometrically in dichloromethane at room temperature. The stoichiometries the were found to be 1 : ratio by Job Method between acceptors. equilibrium constants thermodynamic parameters determined Benesi-Hildebrand Van't Hoff equations. Mirtazapine pure dosage form was applied this study. results indicate...