The iron complex 3 was cytotoxic at low concentrations in K562 cells and could damage the DNA, specifically adenine base.

Crataegus (hawthorn) has long been used as a folk medicine all around the world. Most of studies with species focus on effects heart failure and cardiovascular disease. The pharmacological have attributed mainly to content flavonoids, procyanidin, aromatic acid cardiotonic amines. present study investigated blood pressure structure coronary arterial wall L-NAME-induced hypertensive rats given an aqueous leaf extract C. tanacetifolia (100 mg/kg), for 4 weeks via gavage. It was observed that...

Abstract Morinda citrifolia L. (Noni) is a herbal remedy with promising anti‐cancer properties. However, its effects on various cancers are to be investigated make firm conclusion before implementing it into the clinical practice. Therefore, we cytotoxic potential of noni Ehrlich ascites tumor grown in female Balb‐c mice and also combined potent agent, doxorubicin. One group received only ( n = 8), another one doxorubicin other + 8) for 14 days after inoculation cells. The control 7) 0.9%...

Erythropoietin (EPO) suppresses epileptic seizures, but the mechanism is unclear. The search for novel targets in therapy of epilepsy has focused recently on brain inflammation since and associated blood-brain barrier (BBB) damage appears to be an integral part pathophysiology. We examined effects EPO proinflammatory mediators serum PTZ-induced generalized seizure model. markers (IL-1β, TNF-α, IL-6, IL-10), BBB neuron (S100B, Neuron specific enolase; NSE, respectively) Sprague-Dawley male...

Abstract Lung structural changes and immunoreactivity of endothelial (eNOS)‐ inducible nitric oxide synthase (iNOS) were investigated by light microscopy in lungs treated untreated diabetic rats. Diabetes was induced a single intraperitoneal (i.p.) injection 65 mg kg −1 streptozotocin (STZ) Wistar albino male Diabetic rats received daily i.p. doses dexamethasone (2 ), leptin (0.5 µg ) intramuscular insulin (20 U or combination these drugs for 1 week starting 4 weeks after the STZ injections....

Although it is accepted that prolonged and repeated seizures can cause epileptogenesis, memory deficits neuronal death, the precise relation between epileptic death remains unclear. Erythropoietin (EPO) exhibits neuroprotective anti-epileptic effects. We investigated effect of a single pentylentetrazole (PTZ) induced tonic-clonic seizure on pyramidal neurons cornu ammonis 1 (CA1) CA3 regions hippocampus. also effects EPO seizure, brain-derived neurotrophic factor (BDNF), tyrosine receptor...

It has been known that susceptibility to some types of epilepsy is affected by sex. In addition, the role NO in epileptogenesis still unclear; suggested be either an anticonvulsive or a proconvulsive agent. attempt elucidate both and sex differences sensitivity seizures, male female Wistar rats were treated intraperitoneally (i.p.) pentylentetrazol (PTZ)(80 mg/kg) nitric oxide synthase(NOS) inhibitor N-omega-nitro-L-arginine-mthylester(L-NAME)(50mg/kg) precursor...

Abstract The aim of this study was to investigate the protective effects vanadyl sulfate on aorta tissue normal and streptozotocin (STZ)‐induced diabetic rats, morphologically biochemically. animals were made by an intraperitoneal injection (65 mg/kg) (100 that given every day for 60 days gavage technique rats. Under light transmission electron microscopes, hypertrophy vessel wall, focal disruption in elastic lamellae, increase thickness total aortic tunica intima, subendothelial space...

Purpose: We aimed to evaluate the influence of current antifibrotic agents as well possible results obtained by combining these agents. This study included α-tocopherol, a strong and an efficient neuromediator pathways used other agents.Materials Methods: Mitochondrial Bcl-2, Bax, cytochrome c cytoplasmic caspase-3 expression, toxic effect patterns, mitosis cellular reactions due α-tocopherol alone or combined with paclitaxel, mitomycin C 5-flurouracil (5-FU), was studied in series from...

OBJECTIVES: We aimed to evaluate the effects of leptin and nitro-L-arginine methyl ester hydrochloride (L-NAME) on testicular damage expression nitric oxide synthase (NOS) types (neuronal, endothelial inducible NOS) in streptozotocin (STZ) -induced diabetic non-diabetic rats.METHODS: Testicular was evaluated histologically NOSs immunohistochemically testis.Plasma level blood glucose were assessed.RESULTS: Blood levels increased all groups.L-NAME reduced it, but had no effect.Three NOS shown...

Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvulsive action.Valeriana officinalis (VAL) was previously believed antiepileptic, but today as sedative sleep regulator.Seizures may associated abnormal electrocardiographic changes cardiac dysfunction arising from epilepsy related neuronal nitric (nNO).This study aimed investigate the effects of synthase (nNOS) inhibitor 7-Nitroindazole (7-NI) VAL on seizure behaviours parameters in pentylentetrazole...

It is known that the systemic response during sepsis caused by proinflammatory mediators such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα). The inflammatory in causes disorders brain addition to multiorgan dysfunctions including kidneys liver [1]. Inducible nitric oxide synthase (iNOS) induced hepatocytes mediates hepatic injury [2]. Matrix metalloproteinases (MMPs) play an important role formation of mediate tissue damage [3]. On other hand, there are...

A case of mycobacteriosis in European sea bass (Dicentrarchus labrax L.) cultured Turkey is described. Diseased fish were characterized by lethargy, lingering passively at the water sur- face, pale gills, and exophthalmia. Internally, grayish-white nodules observed liver, spleen, kidney. In one individual, a granulomatous mass renal origin protruded into abdominal cavity. The principal histological feature was occurrence characteristic granu- lomas with associated acid-fast, rod-shaped...