Multiple sclerosis (MS) is a central nervous system disease characterized by inflammation, axonal demyelination and multifocal plaques.Sleep problems due to restless legs syndrome (RLS) are frequently encountered in MS patients.Changes oxidative stress level liver enzyme activity deterioration of trace element homeostasis observed RLS patients.This study was conducted determine serum parameters levels patients with without RLS.Thirty healthy individuals (control), 30 (MS group) (MS+RLS were...

We investigated the effects of thymoquinone (TQ) on expression liver microRNAs (miRNAs), histopathology and oxidative stress in Ehrlich acid solid tumor model induced mice. used 24 male BALB/c mice divided randomly into three groups. Control (C) group were injected intraperitoneally (i.p.) with 0.5 ml saline for four weeks. Tumor (T) i.p. weeks, then cells subcutaneously neck to induce formation. TQ (T + Tq) 10 mg/kg this At end study, from all groups removed histopathological miRNAs...

Although endogenous estrogen is known to offer cardiac and vascular protection, the involvement of receptors in mediating protective effect on hypertension-induced cardiovascular renal injury not fully explained. We aimed investigate effects receptor (ER) agonists oxidative injury, functions rats with renovascular hypertension (RVH). Female Sprague-Dawley were randomly divided as control RVH groups, groups had either ovariectomy (OVX) or sham-OVX. Sham-OVX-RVH OVX-RVH received ERβ agonist...

Background/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H₂S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. Materials Methods: Rat hearts were studied with Langendorff technique using H₂S donor sodium hydrosulfide (NaHS, 40 μM) cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) administered before...

Abstract Lung structural changes and immunoreactivity of endothelial (eNOS)‐ inducible nitric oxide synthase (iNOS) were investigated by light microscopy in lungs treated untreated diabetic rats. Diabetes was induced a single intraperitoneal (i.p.) injection 65 mg kg −1 streptozotocin (STZ) Wistar albino male Diabetic rats received daily i.p. doses dexamethasone (2 ), leptin (0.5 µg ) intramuscular insulin (20 U or combination these drugs for 1 week starting 4 weeks after the STZ injections....

We investigated the effects of Nigella sativa on apoptosis and gamma-aminobutyric acid (GABAA) receptor density in cerebral cortical hippocampal neurons a pentylenetetrazol (PTZ)-induced kindling model rats. The PTZ was produced by injecting subconvulsive doses to rats days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22 24 study into animals treated (PTZ) + N. (PTZ NS) groups. Clonic tonic seizures were induced convulsive dose day 26 study. Rats NS group also with 10 mg/kg methanolic extract 2 h before...

Abstract Hyperglycaemia, hyperlipidaemia, hypertension and obesity are the main risk factors affecting development prognosis of ischaemic heart disease, which is still an important cause death today. In our study, male Sprague–Dawley rats were fed either a standard diet (SD) or high fat carbohydrate (HF‐HCD) for 8 weeks streptozotocin (STZ) was injected at seventh week feeding period. one set rats, mixture prebiotic probiotics (synbiotic, SYN) administered by gavage starting from beginning...

In this study, we investigated the protective effects of angiotensin IV (Ang IV) on cognitive function in streptozotocin (STZ)-induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Ang (5 µg/kg, s.c.) and Dia+Ang IV. The passive avoidance Morris water maze (MWM) tests used to evaluate learning memory performance. Behavioral carried out between 21 30 days after initial injection. Hippocampi dissected retained...

Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region Turkey, is used as medicinal teas for weight loss and hyperglycaemia folk medicine. Objective The study investigated possible effects of P. leaves aqueous extract's on biochemical-histological changes rats fed a high-energy diet (HED), also isolated determined main phenolic compounds. Materials methods Twenty-four male Wistar albino were divided into four equal groups such HED group HED, PLE given only...

The protective effects of thymoquinone on learning and memory abilities hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength 6.0 ± 0.5 V/m for 1 h each 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) radiation-exposed resulted better performance than that not receiving thymoquinone. Electromagnetic field-exposure led increased superoxide dismutase, glutathione peroxidase, malondialdehyde levels lowered brain-derived neurotrophic...

Our study aimed to determine the effects of losartan and PD123319 in ischemia–reperfusion (IR) injury isolated perfused rat heart. The used 40 male Wistar albino rats that were grouped as Control, IR, IR treatment groups received (20 mg/kg), losartan+PD123319. hearts attached Langendorff heart system by employing situ cannulation method, cardiodynamic parameters recorded during experiment. At end experiment, retained for biochemical analysis all data statistically evaluated. A partial...

Combined use of a chemotherapeutic agent and an autophagy inhibitor is novel cancer treatment strategy. We investigated the effects chloroquine (CQ) on lung pathology caused by both solid Ehrlich ascites carcinoma (EAC) doxorubicin (DXR). A control group eight experimental groups adult female mice were inoculated subcutaneously with 2.5 × 106 EAC cells. DXR (1.5 mg/kg 3 mg/kg) CQ (25 50 alone or in combination injected intraperitoneally days 2, 7 12 following inoculation Lung tissue samples...

Many medical or pharmaceutical plants have been widely used for the treatment of liver injury. Silymarin is now as a food-supporting material patented product. Herbal cream has anti-inflammatory and antioxidant effects on wound healing in hemorrhoid model. This study aimed to evaluate herbal silymarin carbon tetrachloride (CCl4)-treated animals. Male Wistar rats were divided into seven groups Intact control, Control, (0.5 ml, intrarectal), (70 mg/kg, CCl4 (2 ml/kg, intraperitoneal),...

Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvulsive action.Valeriana officinalis (VAL) was previously believed antiepileptic, but today as sedative sleep regulator.Seizures may associated abnormal electrocardiographic changes cardiac dysfunction arising from epilepsy related neuronal nitric (nNO).This study aimed investigate the effects of synthase (nNOS) inhibitor 7-Nitroindazole (7-NI) VAL on seizure behaviours parameters in pentylentetrazole...

Because epilepsy pathogenesis is affected by serum minerals and antioxidant enzymes, this study was designed to evaluate whether there a relationship among electrolytes (Na, Ca, K, Cl, P, Mg), trace elements (Fe, Zn, Cu) oxidative stress in patients with generalized or focal epilepsy.Twenty healthy individuals (control group), 20 (patient groups) were included the study.Control patient groups matched age (30 -40 years old), body mass index (25 -28) sex (10 males 10 females).Serum Na, Mg Fe...

Objective: This study was designed for investigating the effectiveness of Nigella sativa (N.sativa) extract on apoptosis in cerebrum and hippocampus also plasma oxidative stress, pentylenetetrazol (PTZ)-induced kindling rats. Materials Methods:The model induced by subconvulsive doses (35 mg/kg i.p.) intraperitoneal PTZ injections N. treated non-treated groups (PTZ + NS).The NS group were with an (10 mg/kg) 2 h before each injection.The total oxidant antioxidant status, stress index,...

Objective: Intermittent hypoxia (IH) implementation is a method performed by intermittently decreasing oxygen concentration in inhaled air at specific rate. This varies between studies terms of its application. study aims to examine the changes Complete Blood Count (CBC) parameters caused IH therapeutic dose ranges with single model.
 Methods: Ten Sprague Dawley type adult male rats were divided into two groups. In group, FiO2 level air, was reduced 10% hypoxic cycle. 5 minutes...

Electrical stimulation is proposed to exert an antimicrobial effect according studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified (E), sepsis (S), (SE) groups. Staphylococcus aureus (1 x 10 9 colonies) 1 ml medium was intraperitoneally injected produce a model. The E SE groups exposed low direct electrical...